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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A retrospective analysis is presented of 38 cases of malignant lymphomas of the stomach, 20 of the reticulum cell type, 6 lymphoblastic, 6 lymphocytic and 4 mixed forms. Two patients had a primary Hodgkin's malignant lymphogranuloma. A follow-up was obtained for 35 patients. There proved to be no significant difference between the symptomatology of carcinoma and lymphoma of the stomach. In patients with lymphomas only signs of stenosis were missing, although the majority of the tumors were located in the antrum. As a consequence of the extreme tendency of the lymphomas to exulcerate (89%), the mean duration of symptoms of 21/2 months (patient's delay) is shorter than that for carcinomas. Malignant lymphomas of the stomach are very difficult to identify as such by radiology and endoscopy, because of their uncharacteristic macroscopic appearance. The best diagnostic method has proved to be endoscopic wire-loop biopsy, which serves to obtain adequate material for histology. An unexpected finding was that at the time of operation half of the patients had clinical stage I E. This indicates that lymphomas remain limited to the stomach longer than carcinomas do. The prognosis depends on both histological type and clinical stage. It is somewhat better than that of nodal malignant lymphomas. The 5-year survival rate of all cases with malignant lymphoma of the stomach is 31%.
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PMID:[Primary malignant lymphoma of the stomach. Analysis of 38 cases]. 43 96

The features of mitotic regimen of lymphogranuloma were established in examinations of 50 involved lymph nodes in patients with lymphogranulomatosis: increased mitotic activity and the number of pathological mitoses from lymphoid prevalence to lymphoid exhaust. In all the types of metaphase was the predominant stage of mitosis. Significant differences were found in the mitotic regimen and various subtypes of nodular sclerosis.
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PMID:[Mitotic conditions in different variants of lymphogranulomatosis]. 49 92

A group of 22 lymfoepitheloid malignant lymphomas was singled out from a wider group by means of demonstating nuclear atypias in epitheloid cells. There were three roughly equal subgroups: the first corresponding to malignant lymphogranuloma, the second to different malignant lymphomas of the ono-Hodgkin type. At first, the third group could not be recognized as a malignant lymphoma other than according to different sorts of atypia of each of the epitheloid cells in granulomas.--The general behaviour of malignant lymphomas of the first two subgroups was in keeping with the properties of the respective basic tumour. The third subgroup was more independent. At each subsequent check-up, the epitheloid granulomatous component of the tumour was seen gradually disappearing. It appeared to a secondary feature in most cases. The cause of atypia in epitheloid cells remained unexplained. Nonetheless, these atypias are an important diagnostic facilitating the identification of a more independent form of lymphoepitheloid malignant lymphoma, the subsequent development of which mostly shows signs of a moderately pleiomorphnous malignant lymphoma, sometimes obviously belonging in the T series.
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PMID:[Lymphoepitheloid malignant lymphoma (Lennert)]. 69 10

A primary extranodal lymphogranuloma of Hodgkin was found in the small bowel (PS II AE) of a 34-year-old man. Two years after radical surgery followed by local telecobalt therapy, the patient is in good health. The symptomatology, therapy and prognosis of this rare form of Hodgkin's lymphogranuloma are briefly reviewed.
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PMID:[Primary extranodal lymphogranulomatosis of the flexura dodenal-jejunalis]. 99 24

The spreading of Hodgkin's disease in the bone marrow is of primary diagnostic significance in respect of its quantity as well as its quality, and therefore has to be taken into account from the initial staging procedure. The iliac crest is the most suitable site of the biopsy, the diagnostic significance of which depends on the adequate size of the specimen and on the technical standard of the histologic embedding with methacrylate, affording perfect semithin sections without decalcification. The prognostic value of the statement of Hodgkin's disease spreading in the marrow deserves further careful evaluation. A nonspecific reaction of the marrow against extramedullary lymphogranulomatosis closely resembling to the so-called tumor myeopathy has to be distinguished from the localized marrow changes due to the tumor itself. The former is depending primarily of the progress of the disease, the latter of its type as well. The well-known histologic classification covers the changes of the bone marrow due to Hodgkin's disease also. The different histologic types however exhibit a varying tendency of expansion within the bone. Generally the marrow involvement is accompanied with more severe clinical and hematological symptoms. The bone is altered mostly in the very region of the infiltration. This is not the consequence of direct tumorous destruction but of stimulation of environmental mesenchymal activities. Parenchymal and mesenchymal changes of the bone marrow, either directly or indirectly connected with the lymphogranulomatosis, are considered primarily as sequelae of the basic disease. The very close structural relationship between the original lymphogranulomatosus growth and these changes is one of the characteristics of Hodgkin's disease. As yet, there is no unequivocal pointer to structural characteristics whose appearance can exert an obstructive or stimulating effect on the lymphogranuloma tissue, apart from the number of lymphocytes and normal histiocytes in the specific infiltrate itself. Our observations of a special role of megakaryocytes in this connection deserve further attention.
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PMID:[The significance of histologic assessment of the bone marrow in Hodgkin's disease]. 100 65

Immunological disorders can play an important role in the etiopathogenesis of malignant lymphogranuloma. The authors demonstrate a patient with autoimmune polymorbidity (polymyositis and type 1 diabetes mellitus) which underwent a long-term immunosuppressive and cytostatic therapy. After 7 years of that treatment, Hodgkin's disease of mixed cellularity type developed. The clinical findings of the case are described and the clinical particularities along with possible mutual links among these diseases are stressed.
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PMID:Secondary Hodgkin's disease in polymyositis and type 1 diabetes mellitus after a long-term immunosuppressive treatment. 134 8

The selective (apoptotic) necrosis of Hodgkin's cells in malignant lymphogranuloma appears to be etiologically quite different from focal one due to ischemic-vascular causes. The morphology and supposed etiopathogenesis of this cellular lesion, as well as the karyoclastic process-presumably apoptotic in nature-are briefly described and considered as a mechanism leading to cellular regression with subsequent destructuralization and release of DNA-reactive nucleoprotein material in form of free hematoxylin bodies. An original observation of the immunoreactivity of Hodgkin's cells with antinuclear antibodies of human serum in a case of collagenosis is also described.
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PMID:Selective monocellular necrosis of Hodgkin's/Reed-Sternberg cells and their immunoreactivity to human serum antinuclear antibodies in NS- and MC-types of malignant lymphogranuloma. 143 29

Monoclonal antibodies and techniques of molecular genetics have shown Hodgkin's disease to be a clonal neoplasm, and that Hodgkin's and Reed-Sternberg cells--malignant cells in this lymphoma--are either of B-lymphoid, T-lymphoid, or myelo-monocytic cell origin. Hodgkin and Reed-Sternberg cells have high multiplicative potential. Their scarcity in lymphoma tissue in relation to nonneoplastic cells has been attributed a) to prolonged cell-cycle, or b) to secretion of lymphokines by which malignant cells attract reactive cells and become "diluted" in formed lymphogranuloma. Different histological subtypes of Hodgkin's disease seem to be correlated with different origin of malignant cell clones. In lymphocytic depletion, malignant cells are usually of B-lymphoid origin; in mixed cellularity and nodular sclerosis they are usually of T-lymphoid origin. In some cases, malignant cell clone is neither of B-lymphoid, neither of T-lymphoid origin; these cells might be "frozen" at a very low differentiation stage.
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PMID:[The origin and clonal proliferation of malignant altered cells in Hodgkin's disease]. 236 21

Some peculiarities in a course of stage I-II Hodgkin's disease with a primary site below the diaphragm are analyzed. This site is more common in men and in a mixed cell histological variant of lymphogranuloma. The frequency of recurrence is higher in this group than in patients with a primary site above the diaphragm. Recurrences affect more frequently the lymphatic areas above the diaphragm. The data obtained suggest the necessity of irradiation of the lymphatic collectors on both sides of the diaphragm in a primary site below the diaphragm, particularly in patients with "mixed cell" and "lymphoid depletion" histological variants of lymphogranuloma.
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PMID:[Course of lymphogranulomatosis with primary location below the diaphragm]. 334 99

A case of lymphogranulomatosis involving the left broad ligament in a 68-year-old patient is reported. The lymphogranuloma with the extent of two fists presented like an immobile ovarian tumour on palpation. An abdominal hysterectomy with bilateral salpingo-oophorectomy and lymphnode resection was performed. No complications occurred during the postoperative course. Haematologic treatment was subsequently initiated.
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PMID:[A lymphogranulomatosis simulating an ovarian tumour (author's transl)]. 690 94


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