Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifty-one lymphograms were performed in children; the indications, technique and results are discussed. Indications are the search for retroperitoneal involvement in lymphogranulomatosis, lympho-sarcoma and reticulum cell sarcoma; in the search for metastases from malignant tumours, particularly abdominal neuroblastoma, soft tissue sarcomas of the abdomen and lower extremities, testicular tumours and malignant melanomas and finally, for primary lymph-oedema and lymphangiomas. Technique is the same as for adults, but requires particular manual dexterity. Children under six years require general anaesthesia. Amongst 28 children with malignant lymphomas, pathological changes in the retroperitoneal lymph nodes were found in seven. In six, this resulted in a change of the staging. Five out of 16 lymphograms in children with malignant tumours showed evidence of lymph node metastases. All six lymphangiograms in children with lymphoedema and lymphangiomas were abnormal.
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PMID:[Lymphography in childhood (author's transl)]. 12 77

148 cases of parotid gland tumours which had been treated during the last 15 years were analysed histomorphologically: There was found in 54.1% mixed tumour (pleomorphic adenoma), 11.5% epithelial malignant tumour, 4.1% sarcoma, 7.4% primary metastasis, 22.9% other benignant tumours. In 2.5% of 80 cases of mixed tumour a malignant degeneration was revealed. Some cases of double tumours and more seldom tumours as for instance lymphoepithelioma and malignant papillary cystadenoma are presented. A critical appraisal of primary sarcomas is following, but also a comment to the problem of primary metastasis in the parotid gland. The author's opinion is now: favourable therapeutic results can be reached in cases of small and modestly enlarged mixed tumours by means of the so-called "extracapsular" or "extended extracapsular" removal on the understanding that a critical casuistic choice was made and a skilled surgical procedure was applied. On this way relapses have been observed in 2.6% of the author's cases till now. A five years survival time of epithelial malignant tumours was found in 17.7% (88.2% of all epithelial malignant tumours had been treated at stage III and IV). All patients suffering from a sarcoma died within a period of 1/2 to 3 1/2 years after therapy except a case of Hodgkin's sarcoma (8 1/2 years). Primary metastasis in the parotid gland in cases of malignant tumours of head and skull sometimes was discovered in the author's cases, the infavourable prognosis of which was similar to primary malignant tumours at all.
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PMID:[Tumours of the parotid gland--results of their treatment and some peculiarities (author's transl)]. 13 50

The occurrence and characteristics of intracellular immunoglobulin inclusions in non-Hodgkin's lymphomas are described. Lymphoma cells from three patients with immunoblastic sarcoma contained classic cytoplasmic, periodic acid-Schiff (PAS)-positive Russell bodies. Immunoperoxidase staining revealed monoclonal IgG (k) in two cases and a polyclonal pattern in the third case, where the tumor evolved from a reactive lesion. Unusual cytoplasmic inclusions were observed in the neoplastic cells of two patients with follicular center cell lymphoma. In one case large globular structures lacking a distinct limiting membrane were seen, while the cells of the other patient contained "signet-ring-like" vacuoles filled with microvesicles. Both were PAS-negative and showed monoclonal immunglobulin staining. In two other cases PAS-positive intranuclear inclusions consisting of monoclonal immunoglobulin IgM(k) could be demonstrated. The possible significance of these findings in B-lymphocyte derived neoplasms is discussed.
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PMID:Immunoglobulin inclusions in non-Hodgkin's lymphomas. 20 30

Untreated Danish Hodgkin's disease (HD) patients and paired age- and sex-matched controls were tested for serum antibodies to Epstein-Barr virus (EBV), six strains of influenza virus and Simian sarcoma virus/Simian sarcoma-associated virus [SSV(SSAV)] antigens. HD sera showed significantly elevated titers against EBV and both increased incidence and mean titer of antibodies to the envelope glycoprotein of SSV(SSAV), whereas testing against the influenza viruses revealed no differences between HD and controls. A focus reduction assay demonstrated a low incidence in HD and controls of sera with neutralizing effects against SSV(SSAV) and the "baboon" C-type virus component of the human HL-23 virus complex, which seemed coupled to HL-A type W19.
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PMID:Elevated titer of antibodies to Simian sarcoma virus envelope antigen (gp70) and normal response to influenza virus in untreated Danish Hodgkin's patients. 22 81

Many nodular primitive non-Hodgkin's lymphomas of the spleen have a favourable course after splenectomy or chemotherapy. Several observations of this type have been reported in the literature, in which the concept of malignancy is discussed, authors referring to a presarcomatous state or to an idiopathic splenomegaly. The evaluation of the extension of those sarcomas, however, very often show hepatic lesions, and always an increase in the lymphoid marrow nodules. The significance of these nodules is discussed here, with reference to 14 personal observations. These nodules may not always reflect a real extension of the sarcoma to the marrow. From a practical point of view, the presence of lymphoid marrow nodules, when associated with an isolated splenomegaly, is a strong argument to suspect a sarcoma of the spleen, and indicates a splenectomy.
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PMID:[Lymphomas of the spleen and bone marrow lymphoid nodules (author's transl)]. 23 26

The clinical and pathologic findings in six patients with myelogenous leukemia presenting initially as multiple granulocytic tumors of the skin were reviewed. The skin of the trunk was most commonly involved with multiple, confluent erythematous plaques and soft, tender, non-ulcerated, violaceous nodules. Two patients had been treated for malignant lymphoma eight and nine years prior to the onset of skin lesions (Hodgkin's disease and nodular lymphocytic lymphoma, respectively), and cutaneous granulocytic leukemia developed in sites of irradiated skin. The skin biopsies in all cases were originally misinterpreted by the pathologist as malignant lymphoma and the correct diagnosis of granulocytic leukemia was not established in any of the cases until overt extracutaneous involvement was detected. The interval in the six patients from skin biopsy to definite involvement of blood and bone marrow by acute granulocytic leukemia ranged from three weeks to six months with a mean interval of 3.8 months. The mean duration of survival from the diagnosis of extracutaneous dissemination was 12.7 months (range of three months to two and one-half years). Poorly differentiated myelogenous leukemia was demonstrated at postmortem examination in all cases. Cytochemical stains of formalin-fixed, paraffin-embedded tissues confirmed the granulocytic origin of the neoplasm: leukemic cells in skin biopsies, bone marrow aspirates, and autopsy specimens contained abundant naphthol AS-D chloracetate esterase. The findings indicate that granulocytic leukemia may rarely present with skin tumors as the original manifestation of the disease. Recognition of the distinctive clinical, histopathologic, and enzyme histochemical features of the lesion provide a basis for distinguishing granulocytic sarcoma of the skin from mycosis fungoides and other cutaneous malignant lymphomas.
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PMID:Multiple granulocytic tumors of the skin: report of six cases of myelogenous leukemia with initial manifestations in the skin. 32 49

In 2.9% of 1762 patients with pleura exudate, the underlying disease was a lymphoreticular sarcoma. The experienced cytologist has no difficulties to differentiate typical patterns of plasmocytoma, reticulumcell sarcoma or lymphogranulomatosis. But there may be borderline forms which can only be evaluated by critical examination. This holds true especially for differentiated types of lymphosarcoma which resemble the pattern of lymphocytic leukemia or observed through low magnification look like lymphocytic exudate. Therefore the use of oil immersion is necessary for evaluation of the smear. Fluorescence microscopy offers some advantages in special problems.
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PMID:[Cytology of pleura exudate in lymphoretic sarcoma (author's transl)]. 33 4

The diagnosis and classification of malignant lymphomas is based upon traditional histological criteria evolved over the years by successive generations of pathologists. Immunoperoxidase methods applied to formalin paraffin sections have permitted a direct correlation of these established morphologic criteria with newer immunological concepts of the form and function of the B lymphocyte and its derivatives. Study of material from 500 cases of Hodgkin's disease, non-Hodgkin lymphomas, and myeloma has revealed that many of these conditions may find a common origin in the lymphocyte, and that some malignant cells, previously identified as malignant histiocytes or reticulum cells are rather related to or derived from the transformed lymphocyte or immunoblast. The corresponding tumors are thus more logically designated immunoblastic sarcoma. The study also reveals a claser developmental relationship between multiple myeloma and immunoblastic sarcoma than previously suspected, and suggests that all of the B cell lymphomas occur as part of a continuous spectrum of disease, rather than as separate entities as implied by current histological classifications. The study of immunoglobulin in formalin paraffin sections is illustrative of the great potential of this method in the diagnosis and study of neoplasia in general.
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PMID:Immunocytochemical methods in the study of lymphoma and related conditions. 35 39

Malignant tumors of the lymph nodes are very widespread in Iran. Out of 15,792 lymph nodes examined during a period of 25 years, in 22% of the cases, the diagnosis was a primary malignancy, and in 10% we had metastatic deposits. Out of 40,690 cancer cases diagnosed in pathology laboratories in Tehran, 8.4% were primary malignant tumors of lymph nodes, with a sex ratio of 3:1. The anatomical distribution of malignant lymph nodes shows 46% in the head and neck, with 17% deep in mediastinal or mesenteric areas. The histological typing of these malignancies shows 40% to be Hodgkin's disease, and 60% sarcoma. The distribution by age group shows that these malignant tumors are observed in patients of all age groups, the highest frequency being found between 20 and 54. The statistical data collected in four provinces of Iran, from North to South, reveal that these malignant tumors are observed with the same frequency in other parts of Iran.
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PMID:Some aspects of malignant tumors of the lymph nodes in Iran. 36 18

Fifteen cases with haemolytic changes in the region of the eye, i.e. ten cases of lymphocytic sarcoma, two cases of M. Hodgkin, two cases with reticulosarcoma and one of acute lymphatic leukosis are presented. With cytologic punctions of the eyelids and of the retrobulbar tissue, typical cytomorphologic findings for above mentioned haemoblastoses were obtained.
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PMID:[Cytomorphologic findings in the diagnosis of intraocular lymphocytic tumors (author's transl)]. 37 43


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