Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bleomycin is an anti-neoplastic antibiotic used in chemotherapeutic regimens for Hodgkin lymphoma, testicular tumour and Kaposi's sarcoma and to induce chemical pleurodesis in malignant effusions. Bleomycin toxicity predominantly affects the skin and lungs. Skin toxicity classically presents as flagellate erythema, a rare drug rash, where the patient appears to have been whipped. Bleomycin-induced pneumonitis is more commonly recognised and can occasionally prove fatal. Although both these conditions are well documented in the literature, in clinical practice they are uncommon. Indeed, in our institution (a teaching hospital with a large lymphoma practice) we cannot recall a previous case of flagellate erythema. Both skin and lung toxicities induced by bleomycin usually respond to discontinuation of the drug and steroid therapy. We present two case studies of patients with bleomycin-related toxicity and a short synopsis of current literature.
 ...
PMID:Toxicities associated with bleomycin. 2112 62

Bleomycin has been used most commonly in the treatment of Hodgkin's lymphoma, certain germ cell tumors (GCT) and for the sclerosis of recurrent pleural effusions. Bleomycin toxicity predominantly affects the skin and lungs. Skin toxicity includes Raynaud's phenomenon, hyperkeratosis, nail-bed changes and palmoplantar desquamation. Flagellate erythema is an unusual rash occurring specifically during bleomycin use. In the present study, we report a case of bleomycin-induced flagellate erythema in a patient with GCT. A 42-year-old male was diagnosed with stage IIIB testicular cancer and treated with bleomycin, etoposide and cisplatin chemotherapy. After 10 days from the initiation of treatment, the patient subsequently developed a generalized pruritus and erythematous linear rash that was most prominent on the trunk, and upper and lower extremities. The patient was commenced on a short course of low-dose oral prednisolone, 20 mg daily, and antihistamine. Consequently, bleomycin was withheld from the patient's treatment regimen. The present study describes the case, along with a review of the associated literature.
 ...
PMID:Bleomycin-induced flagellate erythema: A case report and review of the literature. 2500 66