Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An analysis of the staging procedure in 80 patients with histologically confirmed Hodgkin disease was performed at Tata Memorial Hospital, Bombay. There was a marked male preponderance. The mixed cellularity type of Hodgkin disease is the commonest histological variety (47.5%) and has the highest incidence of subsequently proven generalized disease (76%). The lymphocytic predominant variety was the next most common (27.5%) and was present as unsuspected disease in 45% of cases. Systemic symptoms were associated with advanced disease in 57% of clinical IB and 73% of clinical IIB cases. Splenic involvement was histologically confirmed in 41% of cases with stage I disease and 52% of cases with stage II disease and was associated with liver involvement in two cases. A lymphogram was performed, in addition, prior to the laparotomy in 40 cases and the lymphogram-laparotomy concordance was approximately 72% in our series. This stresses the importance of a staging laparotomy.
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PMID:An evaluation of intraabdominal involvement in Hodgkin disease. 73 38

30 cases of non-Hodgkin-lymphoma with primary bone manifestation were selected from the files of the Bone Tumor Registry of Westfalia from 1975 until 1992. Clinical data and radiologic aspects were evaluated. 60% of the lesions were localized within the long bones (femur 10, humerus 6, tibia 2). The lymphomas were classified based on paraffin-embedded material in combination with immunohistochemical findings according to the updated Kiel-classification. 29 B-cell lymphomas and one T-cell lymphoma of medium-sized pleomorphic type were found. 5 B-cell lymphomas were of low and 23 of high malignancy. Almost 50% of the tumors were of centroblastic type. The Kiel-classification was not applicable for one lymphoma, 3 others could not be subclassified because of shrinking artefacts. Prognosis in patients with localized disease (9 cases) was favorable, whereas only 25% of patients with generalized disease (12/cases) survived for 3 years or longer.
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PMID:[Non-Hodgkin's lymphoma with primary osseous manifestation, from the files of the Bone Tumor Registry of Westphalia]. 128 47

The ultrasound findings of 580 patients with malignant lymphoma were reviewed. Conventional sonography was able to show different extents of distinctly hypoechoic bowel wall thickening due to lymphatic infiltration in 53 patients (9%) who had gastric (n = 37), enteric (n = 5), colonic (n = 7) or multiple (n = 4) involvement. In all patients, the diagnoses were confirmed by histological examination. Non-Hodgkin lymphomas (NHL) were found in 49 patients, while 4 had Hodgkin's disease. As part of staging procedures, sonography enabled the identification of regional and non-regional abdominal lymph node enlargement in 32 out of 53 patients, and therefore subdivides different stages of gastrointestinal lymphoma. Low grade malignant NHL of the gastrointestinal tract (n = 21) tends to represent generalized disease with secondary intestinal involvement (18 out of 21), those of high grade malignancy (n = 28) were present with both primary (n = 15) and secondary (n = 13) lymphoma of the gastrointestinal tract. The results of this study demonstrate the value of conventional ultrasound for identification of both gastrointestinal involvement as well as abdominal lymph node enlargement in lymphoma staging.
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PMID:Sonographic staging of gastrointestinal lymphoma. 227 10

Malignant lymphomas involving the prostate are rare whether as primary lymphoma or as secondary to generalized disease. Middle age, histotype prevalently non Hodgkin, intermediate and high grade of malignancy, symptoms of bladder outflow obstruction, diagnosis generally made after histological examination, severe prognosis are the most important features that result from literature review. The evaluation of therapeutic treatments is difficult as most reports do not include a sufficient number of cases. The Authors presenting two cases of lymphoma of the prostate point out the usefulness of radiotherapy since the prostate is usually a bulky seat of disease and suggest the combination with multiple drug chemotherapy for intermediate and high grade of malignancy and in advanced stages. The authors suggest that prognosis depends on histotype rather than on prostatic involvement of disease.
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PMID:[Lymphoma of the prostate: case reports and subject review]. 229 Oct 13

Forty cases of histiocytosis of Langerhans' cells (26 children and 14 adults) were evaluated; 20 were localized forms (with single or multiple bone involvement); another 20 were generalized forms, with organic dysfunction (lung, liver, hemopoietic system) in 7 children. This feature has a poor prognostic significance, as shown by the fact that 3 of these 7 patients died. In 3 patients single skin involvement was found, with spontaneous recovery one month after the diagnosis in one; in one case the single involvement was lymphadenopathic, associated to Hodgkin's lymphoma, and in another it was hypothalamic. These cases of single involvement have been followed up between 1 and 4 years. In 4 of 7 patients with generalized disease a reduction of OKT8 with an increased OKT4: OKT8 ratio was found, as reported in other cases from the literature. This finding gives support to an immunological rather than neoplastic basis for the disease. In all 40 cases the diagnosis was morphological, with positive staining for S-100 protein in 38.
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PMID:[Histiocytosis of Langerhans cells: a study of 40 cases]. 269 69

According to the literature the non-Hodgkin-lymphoma is involving the kidney and its capsule, the hilus of the kidney and the retroperitoneal space in some instances. Today one assumes that the disease is originating unifocally therefore one can achieve a healing or complete remission by radical surgery when one or both kidneys or a testicle are involved. Prior to this generalised disease must be ruled out. Two cases are reported where one or both kidneys were involved showing long survival time or cure. The prognosis, however, is very poor when the urogenital system is included in systemic forms of non-Hodgkin-lymphoma.
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PMID:[Involvement of the urogenital system in non-Hodgkin lymphoma (primary and secondary involvement)]. 317 11

A peripheral blood eosinophilia was found at presentation in 193 of 1260 (15%) patients with Hodgkin's disease who had been entered into clinical studies by the British National Lymphoma Investigation (BNLI). Eosinophilia as a component of a general leucocytosis conferred no survival advantage. Eosinophilia without a general leucocytosis was present in 95 patients, and this selective eosinophilia was associated with a clear survival advantage. The association of selective eosinophilia and improved survival was limited to patients with mixed cellularity and grade I nodular sclerosis histology. Selective eosinophilia was found to be a good prognostic indicator both in local and generalised disease. Its survival advantage seemed to lie in the response to second line treatment following relapse.
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PMID:Selective peripheral blood eosinophilia associated with survival advantage in Hodgkin's disease (BNLI Report No 31). British National Lymphoma Investigation. 355 57

The number and distribution of reactive cells in more than 100 non-Hodgkin lymphomas (NHL) were evaluated in situ in cryostat sections. The results were compared with histological and clinical findings. 40% of the T cell content of normal lymphatic tissues was found in tissues of B-cell NHL. This corresponds to a mean of 2 X 10(4) reactive T-cells/microliter tumour tissue. The numerical density of natural killer (NK) cells within tumours was similar to that of normal lymphatic tissues (0.5 X 10(4) cells/microliter). The distribution of the reactive cells within the tumours was diffuse except in the case of centroblastic/centrocytic lymphomas. On evaluation of the different histological entities a significant correlation was obtained between number of helper/inducer (TH) cells, TH:T-suppressor (Ts) ratio and prognostically favourable histological subgroups. Furthermore, independent of histological criteria, a close correlation was found between a high number of TH-cells, a high TH:Ts ratio and a favourable clinical course (p less than 0.04). NK-cell infiltration was present to a markedly higher extent in tissues of patients with generalized disease as compared with localized disease (p less than 0.03). Low-grade malignant NHL contained significantly more NK cells than high-grade malignant NHL, as was the case also in treated, as opposed to untreated patients. These findings together suggest that reactive cells influence tumour growth via local interactions. However, tissue distribution and infiltration density of T-cell subpopulations and NK cells were clearly different. Thus, in tumour tissues different and independent immunoregulatory mechanisms seem to be associated with these two lymphocyte subsets.
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PMID:[Infiltration pattern of immunocompetent lymphocytes in the tissue of malignant non-Hodgkin's lymphoma: relationship to histological and clinical parameters]. 387 40

From July 1977 to July 1983, 120 children with non-Hodgkin's Lymphoma entered a randomised trial of combination chemotherapy and radiotherapy. The primary site was abdominal in 42 patients, mediastinal in 27 and in other sites in 51. Failure-free survival (FFS) at 4 years was 74% for the 41 patients with localised disease (Stages I and II) and 51% for the 79 with generalised disease (Stages III and IV). Patients with mediastinal primaries continued to relapse after the completion of 2 years' treatment, but FFS at 4 years for the 93 patients with non-mediastinal primaries was 65% for all stages combined. In the latter group, there was no benefit to patients randomised at the end of induction chemotherapy to receive adjuvant radiation 15 Grays in 10 fractions in 2 weeks to sites of previous bulky disease when compared to those not receiving such radiation (P = 0.6).
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PMID:Adjuvant low dose radiation in childhood non-Hodgkin's lymphoma (report from the United Kingdom Childrens' Cancer Study Group--UKCCSG). 648 15

In order to investigate the natural history of so-called "Lennert's lymphoma" and to reevaluate whether non-Hodgkin's lymphoma with a high content of epithelioid histiocytes represents a clinicopathologic entity, we reviewed the histopathologic and clinical features of 60 patients in whom pretreatment diagnostic tissues had shown a diffuse and florid epithelioid histiocytic reaction identical to that originally described by Lennert and Mestdagh. Our study indicates that so-called "Lennert's lymphoma" is a heterogeneous group of disorders, which, in our series, included Hodgkin's disease (27 patients), non-Hodgkin's lymphoma (24 patients), angioimmunoblastic lymphadenopathy (1 patient), and atypical lymphoepithelioid cell proliferations of uncertain etiology and pathogenesis (8 patients). Most of the patients with Hodgkin's disease had Stage I or II disease without B symptoms, whereas patients with non-Hodgkin's lymphoma usually had Stage III or IV disease, commonly with B symptoms. The median survival was 79 months in the Hodgkin's disease group, compared with 12 months in patients with non-Hodgkin's lymphoma (P less than 0.0001). In patients with atpical lymphoepithelioid cell proliferations, the survival pattern was unpredictable, and the number of patients was too small for a meaningful statistical comparison. Progression to malignant lymphoma in 1 of the 8 patients with atypical lymphoepithelioid cell proliferations, however, underscores the malignant potential of this disorder. One patient with angioimmunoblast lymphadenopathy had generalized disease and constitutional symptoms. In Hodgkin's disease with a prominent epithelioid histiocytic reaction, the gross and microscopic features were similar to those observed in Hodgkin's disease in which this reaction was lacking. In non-Hodgkin's lymphoma, however both the macroscopic and microscopic features differed from those of the usual non-Hodgkin's lymphomas. Moreover, subdivision into poorly differentiated lymphocytic, mixed, and histiocytic types did not reveal any differences in median survival among these subtypes. Non-Hodgkin's lymphoma with a multifocal epithelioid histiocytic reaction previously included in the heterogeneous group called "Lennert's lymphoma" appears to be a distinct clinicopathologic entity.
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PMID:So-called "Lennert's lymphoma": is it a clinicopathologic entity? 698 78


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