Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary lymphoma of the pancreas is a very rare disease. They are difficult to diagnose and have good prognosis, due to their sensitivity to chemotherapy and radiation. As compared to the more common pancreatic adenocarcinomas which usually have bad prognosis. Histological diagnosis relies on good biopsy. We report a case of primary pancreatic non-Hodgkin s lymphoma diagnosed in a 71 year old icteric man. Chemotherapy and radiation therapy was started after relieving the jaundice with a PTC-introduced stent through the pancreatic part of the choledochus. This is the first reported case of pancreatic lymphoma in Iceland.
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PMID:[Primary pancreatic lymphoma causing obstructive jaundice in a 71 year old man. A case report and review of the literature.]. 1694 Jun 48

Primary renal lymphoma is a controversial and rare disease. There is no agreement whether or not it is an initial manifestation of a rapidly systemic disease. Most reported cases are questionable because of incomplete staging and lack of autopsy studies. Herein, we present a 71-year-old woman, initially diagnosed with primary non-Hodgkin lymphoma of the kidney, but was lost 4 months after radical nephrectomy due to systemic disease despite aggressive chemotherapy, and suggest that, the kidney of the patient was the initial presenting site of a rapidly progressive systemic disease.
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PMID:Lymphoma of the kidney: primary or initial manifestation of rapidly progressive systemic disease? 1711 Oct 87

The new imaging techniques used during the last several years: ultrasound, computed tomography and magnetic resonance imaging have improved detection of non-functional adrenal tumours s.c. "incidentaloma". Incidence of adrenal incidentaloma is not very low. They are detected in about 0.35-4.36% CT examination. In most of cases incidentaloma are benign and gave no clinical signs; however primary adrenal cortex cancer and metastases of different cancers are not uncommon. The primary adrenal lymphoma is an extremely rare disease. The predominant group of patients are men over 50 years with other manifestations of non Hodgkin lymphoma. Most frequently both adrenal glands are affected and signs of adrenal insufficiency (despite weakness, fever and loss of weight) are present. In our paper we present a case of primary, unilateral lymphoma in a 19 year old women. It was discovered as incidentaloma in ultrasound examination. Hormonal examinations were normal, but the tumour size was indication for surgery treatment. The diagnosis was made by histological examination and adjuvant chemotherapy was administrated.
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PMID:[Primary adrenal lymphoma in incidentally discovered adrenal tumour]. 1744 88

Bronchus-associated lymphoid tissue lymphoma is a rare disease. It is the most common form of primary pulmonary lymphoma but accounts for less than 1% of all non-Hodgkin's lymphomas. We describe a 67-year-old man who, despite successful treatment of active miliary tuberculosis, developed progression of a concomitant bronchus-associated lymphoid tissue lymphoma. This case is in contrast to previous reports of gastrointestinal-mucosa-associated lymphoid tissue lymphomas and bronchus-associated lymphoid tissue lymphomas, in which treatment of the precipitating antigenic stimulus lead to remission of the lymphoma.
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PMID:Bronchus-associated lymphoid tissue lymphoma and Mycobacterium tuberculosis infection: an unusual case and a review of the literature. 1752 66

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), a distinct subtype of Hodgkin lymphoma, is a rare disease with a generally favorable prognosis. The hallmark of NLPHL is the presence of the lymphocytic and histiocytic cell, which, in contrast to the classic Reed-Sternberg cell, is CD20+, CD15-, and CD30-. NLPHL tends to have an indolent natural history, a long time to disease progression, a delayed time to relapse, and a high likelihood of presenting as early-stage disease. The evidence to guide the management of patients with NLPHL is limited by the rarity of this disease, but the available data support the use of involved-field radiation therapy alone for localized disease. Treatment-related late effects contribute significantly to the causes of death in patients treated for NLPHL.
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PMID:Nodular lymphocyte-predominant hodgkin lymphoma. 1759 65

In this manuscript for the first time we describe the concomitant diagnosis of primary renal non-Hodgkin lymphoma (PRL) and of a papillary urothelial cancer in a patient with megaloblastic anemia. PRL is a rare disease, since the kidney is one of the extranodal organs usually not containing lymphoid tissue. The disease usually affects adults with an average age of 60 years and slight male preponderance. Flank pain is the most common presenting symptom and different histologies have been reported. A review of literature indicated that simultaneous diagnosis of PRL and papillary urothelial carcinoma of the urether, makes our case unique. The early diagnosis of both diseases allowed the eradication of the two neoplasms by nephro-ureterecthomy and by performing subsequent systemic chemotherapy.
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PMID:Concomitant occurrence of a primary renal NHL and of a papillary urothelial ureter cancer. 1772 12

Angio-immunoblastic T-cell lymphoma (AITL), a rare disease that constitutes 1% to 2% of non-Hodgkin's lymphomas, presents in middle-aged and elderly individuals. This report describes a patient with high-grade fever and lymphadenopathy. An extensive in-hospital work-up that included lymph node biopsy yielded negative results. The patient became asymptomatic for 4 wk, but then symptoms recurred with more pronounced lymphadenopathy. A computed tomography scan documented recurrent diffuse lymphadenopathy. Another lymph node biopsy revealed florid changes that strongly suggested AITL. Flow cytometry confirmed this diagnosis. The patient was treated with hyper-CVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone) and achieved complete remission after the first cycle. The patient developed sepsis during the second cycle and expired within 4 mo of diagnosis. The prognosis and natural course of AITL are poor when the classic chemotherapy protocol is administered. When infection has been ruled out, physicians should be wary of aggressive lymphomas that present with diffuse lymphadenopathy and fever.
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PMID:Angio-immunoblastic T-cell lymphoma in evolution: a case report. 1790 Oct 30

Splenic lymphoma with circulating villous lymphocytes (SLVL) is a special kind of lymphoproliferative disease characterized by specific clinical, haematological, histomorphological and immunophenotypic features that make it different from hairy cell leukaemia, prolymphocytic leukaemia and non-Hodgkin lymphoma. Four patients suffering from SLVL, 3 men and 1 woman, 62 years in average (range 55-67 years), are presented. All patients had anaemia and splenomegaly. One patient had huge pseudocyst of the spleen, two had mild lymph-adenopathy, while 3 patients had thrombocytopenia. The number of WBC ranged from 13-29 x 10(9)/l with lymphocytes ranging from 62-80%. Monoclonal IgM paraprotein was found in 3 patients. Immunophenotyping showed cells with features of mature B lymphocytes. Splenectomy was carried out in three patients. They all recovered and stayed symptomfree. One patient refused surgery. In our opinion SLVL is not a rare disease as it was thought; it should especially be taken into diagnostic consideration in elder patients, particularly in males with splenomegaly and lymphocytosis.
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PMID:[Splenic lymphoma with circulating villous lymphocytes]. 1797 22

Paraneoplastic limbic encephalitis (PLE) is a rare disease that is probably caused by an immunological reaction against CNS-structures. It may present with neurological, neuropsychological or psychiatric symptoms. Besides treatment of the underlying neoplastic disease, there is no generally applicable evidence-based treatment. PLE is most frequently associated with certain carcinomas, but its occurrence with Hodgkin lymphoma has also been recognized. Association with non-Hodgkin lymphoma has only been occasionally reported in single cases. We report two additional patients, in whom malignant non-Hodgkin lymphomas of the B- and T-cell lines were detected. Treatment with corticosteroids in one and chemotherapy in the other case were associated with clinical improvement.
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PMID:[Paraneoplastic limbic encephalitis resulting from non-Hodgkin-lymphoma: two case reports]. 1818 22

3 cases of primary non Hodgkins lymphoma of the breast are described, seen over a period of 2 years among 199 cases of breast malignancies. All were diffuse large B cell type. Application of immunohistochemistry greatly aids in differentiating lymphoma from anaplastic carcinoma, with which it can easily be confused. Preoperative diagnosis on a trucut biopsy is an ideal diagnostic method since diagnosis on fine needle aspiration cytology or frozen section may not be possible. Primary breast lymphoma is a rare disease with reported incidence of 0.04-0.53% of all breast malignancies in most series. Accurate diagnosis is essential, so that appropriate treatment may be applied. Two cases were treated with CHOP chemotherapy and radiotherapy along with surgical excision. One case was treated with CHOP chemotherapy.
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PMID:Primary lymphoma of the breast: a clinicopathological study. 1830 36


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