Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Levels of circulating immune complexes (CIC) in the serum of patients with Hodgkin's disease were measured by the Raji cell radioimmunoassay. Elevated levels of immune complexes (mean value of 49 microgram/ml +/- 21 SE) were detected in 20 of 40 (50 per cent) untreated patients. After treatment, the level of CIC was normal (less than 15 microgram/ml) in 39 of 41 patients. Recurrent disease developed in two of the 39 patients with normal post-treatment levels of CIC and in one of the two patients with elevated post-treatment levels during the follow-up period of six months to six years. Elevated levels of CIC were detected in patients with Hodgkin's disease in stages I, II and III but not in stage IV. No significant correlations were found in the frequency of elevated levels of CIC or the values observed, and the presence or absence of symptoms (fever, sweats, weight loss) or the histologic subtype of the tumor. Our data indicate that the measurement of CIC by the sensitive and specific raji cell assay may prove useful in the management of patients with Hodgkin's disease. In particular, serial measurement of the level of CIC could be employed to monitor the response to treatment and to detect recurrent diseases.
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PMID:Circulating immune complexes in Hodgkin's disease. 62 78

Fifty chest radiographs and concurrent thoracic computed tomography (CT) scans obtained in a total of 44 patients with 50 separate episodes of suspected recurrent Hodgkin's disease were reviewed. Recurrent disease was present in 18 episodes, involving the mediastinum in 12, the lung parenchyma in five and both mediastinum and lung parenchyma in one. In four episodes, mediastinal recurrence was demonstrated on both the chest radiograph and CT scan. In a further two cases, the chest radiograph appeared normal but CT detected recurrence in the mediastinum. In 20 cases, the mediastinal appearances on chest radiography were suspicious but not diagnostic of recurrence, usually because of previous radiotherapy resulting in residual mediastinal widening. Computed tomography diagnosed recurrent disease which was subsequently proven in seven of these cases. Recurrent disease was suggested by CT in a further case, subsequently shown to be radiation fibrosis. Of the 12 remaining chest radiographs in which the mediastinal assessment was indeterminate, CT was true negative for recurrent disease in 10 cases and was also indeterminate in two. Recurrent disease in the lung parenchyma was demonstrated on the chest radiograph and CT scan on five occasions. There was one incident in which the chest radiograph was normal but CT detected recurrent parenchymal disease. The appearances of the lung parenchyma were indeterminate for recurrent disease on three chest radiographs but CT was helpful in only one case in which radiation change alone was diagnosed. In eight cases the diagnosis of recurrent disease by CT resulted in a decision to initiate treatment. Computed tomography is of value in detecting relapse in patients with suspected recurrent Hodgkin's disease when the chest radiograph is inconclusive, and may enable differentiation of radiation change from recurrent disease in the mediastinum.
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PMID:The value of thoracic computed tomography in the detection of recurrent Hodgkin's disease. 340 43

One thousand and two consecutive patients with lymphoma were referred to the Regional Radiotherapy and Oncology Centre at Weston Park Hospital, Sheffield from 1970 to 1982 inclusive. Four hundred and seventy (47%) of the lymphomas occurred in the head and neck and 49 (10.4%) of these were extranodal. These 49 patients with primary extranodal lymphoma of the head and neck were reviewed with regard to clinical presentation, histological grade, treatment and survival. The specialists involved in the initial diagnosis were, in order of frequency, ear, nose and throat surgeons, general surgeons, ophthalmic surgeons and oral surgeons. Tonsillar and thyroid lymphomas occurred most frequently and constituted 71.0% of this series. All extranodal lymphomas were non-Hodgkin's lymphomas and two-thirds were graded as histologically unfavourable. Clinical staging showed that 65% of tonsillar lymphomas had local lymph node involvement at the time of diagnosis (Stage II); only 25% of lymphomas from other sites were Stage II. Radiotherapy was the primary treatment and was associated with a cumulative survival rate of 46.5%. Most recurrences were within 1 year and at distant sites. Recurrent disease had a poor prognosis with only 10% achieving lasting remission. Further analysis of cumulative survival after 6 years showed 65.7% for clinical Stage I, 40.9% for Stage II and 67.6% for histological Grade I, 29.9% for Grade II.
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PMID:Extranodal lymphoma of the head and neck: a review of 49 consecutive cases. 407 8

Since the majority of children with acute leukemia and lymphoma are long-term survivors, more attention is directed towards late sequelae of therapy. Intracerebral hemorrhage after treatment of central nervous system (CNS) neoplasia in childhood is a very rare event. A seven and a half-year-old boy was admitted to our hospital because of acute third nerve palsy. Three years and eight months before the patient had been treated for a mediastinal T-cell non Hodgkin's lymphoma (T-NHL) with CNS involvement by combined chemo-radiotherapy. Recurrent disease was excluded, but intracerebral hemorrhage in the tectal area was demonstrated by repeated magnetic resonance imaging. Symptoms of incomplete oculomotor paresis improved spontaneously with conservative therapy. Intracerebral hemorrhage may occur as a rare complication in children with malignant CNS disease even years after treatment with combined chemo-radiotherapy.
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PMID:Intracerebral hemorrhage as a late complication after CNS treatment of childhood lymphoma. 987 96