Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The records of 60 consecutive surgically staged children with newly diagnosed Hodgkin's disease were reviewed to determine the prognostic significance of the presence of a mediastinal mass. Mediastinal mass was present in 38 patients and was more common in (a) females, (b) children greater than 12 years old, (c) association with nodular sclerosis or lymphocyte depletion histology, (d) those with "B" symptoms, and (e) the presence of advanced disease stage. The presence of a mediastinal mass was associated with reduced disease-free survival, the effect being more significant with a mediastinum/thoracic ratio greater than 0.33. The presence of a mass, large or small, did not influence overall survival.
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PMID:Prognostic significance of mediastinal mass in childhood Hodgkin's disease. 707 56

Burkitt lymphoma (BL) is a high-grade, B-cell-originated pediatric malignancy that is a type of non-Hodgkin lymphoma involving different organs. Mediastinal mass, ascites, peritoneal thickening, and infiltration of the small intestine, kidney, and liver were found in our patient. In this case, we describe the radiologic appearances and possible infiltration patterns of multi-organ BL. Also, we discuss infiltration of the periportal area, such as hypodense lesions in the liver, which is rarely seen in BL.
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PMID:A case of Burkitt lymphoma re-presenting as periportal hepatic and multiple organ infiltration. 1850 Oct 90

Adult lymphoblastic lymphoma (LBL) is an aggressive form of non-Hodgkin lymphoma occurring in predominantly adolescent and young adult men, accounting for 1% to 2% of all non-Hodgkin's lymphomas. In contrast to B-LBL, T-cell LBL is much more common, accounting for up to 90% of disease in adults. Mediastinal mass, pleural and/or pericardial effusions are the major characteristics of T-LBL. We report an 18-year-old male with a pleural effusion, mediastinal mass, a light pericardial effusion, and a normal hemogram. The cytology of the pleural effusion initially suggested malignancy, but definitive diagnosis was unclear. After a medical thoracoscopy, the partial pleura was picked and immunophenotypic study revealed the following: CD3(+), TdT(+), CD99(+), CD20(-). The patient was finally diagnosed with T-LBL and died only 6 months after that. The case highlight the point that medical thoracoscopy is a safe and accurate diagnostic procedure for pleural diseases, and partial pleura biopsy with immunophenotyping was essential for achieving the correct diagnosis of LBL.
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PMID:T-cell lymphoblastic lymphoma presenting with pleural effusion: A case report. 2602 43