UMLS:C0019829 - FACTA Search

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Query: UMLS:C0019829 (Hodgkin's disease)
30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary non-Hodgkin's lymphoma of the testis (PTL) accounts for about 9% of testicular neoplasms and 1-2% of all non-Hodgkin's lymphomas. It is the most common testicular malignancy in elder men. Anecdotal reports associated PTL development with trauma, chronic orchitis, cryptorchidism, or filariasis exist, but no case-control studies have confirmed their etiologic significance. Diffuse large B-cell lymphoma (DLBCL) is the most common histotype in primary forms; aggressive histologies, especially Burkitt's lymphoma, are prevalent in cases of secondary involvement of testis. The most common clinical presentation is a unilateral painless scrotal swelling, sometimes with sharp scrotal pain or hydrocele. Systemic B symptoms are present in 25-41% of patients with advanced stage. Less frequently, abdominal pain, and ascites can be seen in patients with involvement of retroperitoneal lymph nodes. Bilateral testicular involvement is detected in up to 35% of patients. Although good results with doxorubicin-containing chemotherapy, followed or not by radiotherapy, have been reported, a high proportion of patients with stage I-II diseases experience aggressive relapses, and patients with advanced disease have a very poor prognosis. PTL has a propensity to disseminate to other extranodal organs, including the controlateral testis, CNS, skin, Waldeyer's ring, lung, pleura, and soft tissue. Orchidectomy followed by R-CHOP combination, with CNS prophylaxis, and prophylactic irradiation of the contralateral testis is the recommended first-line treatment for patients with limited disease. Management of patients with advanced or relapsed disease should follow the worldwide recommendations for nodal DLBCL.
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PMID:Primary testicular lymphoma. 1796 36

Extranodal non-Hodgkin lymphoma (NHL) in head and neck region is most commonly seen in the Waldeyer's ring. Waldeyer's ring is a unique subtype of mucosa associated lymphoid tissue (MALT), which shows rarity of low-grade or MALT-type lymphomas and a high incidence of diffuse large B cell lymphoma (DLBCL). The commonest histology is DLBCL with natural history similar to primary nodal NHL. However, high association with gastrointestinal involvement is reported. The diagnostic workup is similar to that of the usual nodal NHL, and in absence of a specific staging system, the Ann Arbor staging is followed. As compared with T-cell subtypes, B-cell phenotypes are less likely to present with mucosal ulceration, epitheliotropism and angioinvasion. Stage of disease, histology and use of combined modality treatment have been proposed as significant prognostic factors. Treatment has evolved from the use of extended field radiotherapy (RT) alone to the use of combined chemotherapy and RT leading to almost doubling of survival. Advances in pathology and further risk stratification of patients into prognostic groups could lead to the development of novel therapeutic strategies to improve outcome.
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PMID:Non-Hodgkin lymphoma of the Waldeyer's ring: clinicopathologic and therapeutic issues. 1905 73

One hundred and seventy-five patients with extranodal non-Hodgkin lymphoma (NHL) treated between 1974 and 1993 in the Institute of Radiology and in the Department of Haematology of 'La Sapienza' University of Rome, have been examined. The sites involved were: Waldeyer's ring 96 patients (tonsils 84, nasopharinx 12), parotid 20, orbit 16, oral cavity 16, paranasal sinus 7, mandible 7, nasal fossal 3, minor salivary glands 3, larynx 3, conjunctive 2, lacrymal glands 1, thyroid 1. One hundred and forty-three patients had high and medium grade unfavourable histology; 68 patients were in stage I, 67 in II, 23 in III and 17 in IV. Fifteen patients were treated with radiotherapy alone and 86% obtained complete remission (CR). Chemotherapy alone was used in 90 cases and 87% C.R, was achieved; when chemotherapy in association with radiotherapy was used in 70 cases 85% obtained CR. The actuarial survival rate was 79% and recurrence-free survival in those patients who achieved complete remission 87%. Surviving and relapse-free patients were analysed in relation to main prognostic factors and therapy, and patterns of recurrence are reported. From the analysis of these cases we can learn how systemic therapy combined with the general conditions of patients and histology can control the disease. A minor relapse incidence with pharmacological therapy combined with a radiotherapic loco-regional treatment was also ascertained.
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PMID:Head and neck extranodal non-hodgkin-lymphoma - radiation-therapy and chemotherapy. 2155 45

Malignant lymphoma is the second-most common malignancy in the head and neck region. Waldeyer's ring is the most common site of extranodal Hodgkin's lymphoma (NHL) in that region, and a small percentage of primary extranodal NHL occurs in the oral cavity. The most common sites of extranodal NHL in the oral region are the palate and maxilla, and nearly half of extranodal NHL cases arise from bone. It is difficult to diagnose extranodal NHL because of the variety of its radiological features. We report a case of primary extranodal NHL of the maxilla in a 68-year-old female patient with atypical imaging findings, along with the results of analysis of dynamic magnetic resonance imaging (MRI).
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PMID:Primary extranodal lymphoma of the maxilla: a case report with imaging features and dynamic data analysis of magnetic resonance imaging. 2177 83

Malignant lymphoma (Non-hodgkin's lymphoma) is a primary malignant tumor of lymphoid tissue composed of lymphocytic or reticulocytic derivatives of varying degree of differentiation. The tumor frequently occurs in the extranodal sites including the gastrointestinal tract and the Waldeyer's ring. Amongst the non-Hodgkin's Lymphomas, the small cell type is the relatively uncommon lymphoma (4%) whereas others include follicular type (40%) and the high grade type (40-65%). This case report is of a case of primary isolated non-Hodgkin's lymphoma of the tonsil of small cell type.
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PMID:Primary isolated nonhogkin's loymphoma of the tonsil -a case report. 2311 27

Lymphomas represent malignant lymphoproliferative diseases and they are generally classified as Hodgkin's (HL) or non-Hodgkin malignant lymphomas (NHML). Head and neck lymphomas represent one of the most common sites of extranodal lymphomas, second after the gastrointestinal tract. Waldeyer's ring structures include the palatine tonsils, the nasopharyngeal lymphatic tissue, and the lingual tonsil. We investigated 38 patients with malignant lymphoma with ages ranging from 21 to 95 years, all localized in the Waldeyer's ring. Good knowledge of the clinical characteristics of these lymphomas and the methods to establish the differential diagnosis are essential for a correct therapy of the disease.
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PMID:Non-Hodgkin lymphomas of Waldeyer's ring. 2330 32

Primary testicular lymphoma (PTL) is an uncommon disease, and accounts for about 1% to 2% of non-Hodgkin's lymphomas and less than 5% of all testicular malignancies. Of all testicular malignances, primary testicular diffuse large B-cell lymphoma is the most common type, whose incidence is estimated at 0.26/100 000 per year. At presentation or relapse, PTL tends to spread to several extranodal sites, such as the contralateral testis, the central nervous system, skin, lung, pleura, Waldeyer's ring, and soft tissues. Orchiectomy and chemotherapy are the preferred treatment. We report a case of a 40-year-old male presenting with a nodule on the anterior abdominal wall and with right scrotal swelling on physical examination. Histopathologic examination led to the diagnosis of cutaneous metastasis of testicular lymphoma.
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PMID:Primary testicular lymphoma with solitary cutaneous nodule as the initial presentation. 2666 13

Fifty cases of Hodgkin's disease in intravenous drug users (IVDU) have been collected by the Italian Cooperative Group on AIDS-Related Tumors (G.I.C.A.T.). Ninety-two per cent of the patients were males; the median age was 26 years. Persistent generalized lymphadenopathy (PGL) at onset was present in 54% of patients, AIDS in 9%, ARC in 9% while 28% were simply HIV-positive. The initial median absolute number of CD4 lymphocytes was 264/mmc. Opportunistic infections were diagnosed in 20% of patients. In most patients the histological pattern was that of mixed cellularity and lymphocytic depletion (76%). In almost half the initial symptom was a persistent lymph node enlargement due to PGL. In the majority of patients (58%) only a clinical staging and bone marrow biopsy could be performed due to the presence of opportunistic infections, rapid disease progression or refusal of pathologic staging procedures. One patient presented with a Waldeyer's ring involvement, but no other unusual presentations were observed. After MOPP alternated or followed by ABVD or MOPP alone, 15/29 CR (52%) and 14/29 PR (48%) were observed. The median duration of CR was 14 months, while the median survival of CR has not been reached; the median survival of patients treated with chemotherapy with CD4 values at presentation {geq}400/mmc was significantly superior to that in those with CD4 < 400/mmc. The overall median survival was 16 months. Twenty-eight per cent of patients receiving chemotherapy + radiotherapy developed opportunistic as well as non-opportunistic infections (21%). Lethal hepatic toxicity was observed in 2 patients. In conclusion, Hodgkin's disease in IVDU was not found to be associated with unusual presentations, as previously reported for homosexuals. Complete remissions could be achieved in over 50% of patients, but in IVDU non-opportunistic infections in addition to opportunistic infections may also limit treatment administration. The presence of parenchymal functional impairment due to drug abuse, or drug abuse-related infections, such as pneumonia, endocarditis and hepatitis, should lead to the choice of antitumour agents with no or only minor potential liver, lung and cardiac toxicity.
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PMID:Hodgkin's Disease in 50 Intravenous Drug Users with HIV-Infection. 2746 28

Twenty-six non-Hodgkin's malignant lymphomas (ML) of the Waldeyer's ring, the mouth and nasal cavities were studied morphologically and immunohistochemically on paraffin and frozen sections. A B-cell origin was shown in all 14 cases of Waldeyer's ring M.L., while 5 of 7 nasal and 3 of 5 buccal cases were of T-cell nature. Seventy-nine per cent of all the above ML were high-grade malignancies. Combined morphological and immunohistochemical studies of such malignant lymphomas in Western populations have been reported rarely and are rather limited. The documentation of the first nasal and buccal cases of anaplastic Ki-1 positive peripheral T-cell ML is emphasised in conjunction with the more frequent carcinomas of the same anatomical areas under consideration.
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PMID:Primary Non-Hodgkin's Lymphomas of the Nasal and Mouth Cavity and the Waldeyer's Ring: A morphological and immunohistochemical study. 2746 30

Methionine transport across plasma membranes occurs via the large amino acid transporter, which is overexpressed in malignant cells, leading to tracer accumulation within tumors. We investigated the uptake of ¹¹C-methionine (¹¹C-MET) in children and young adults with Hodgkin lymphoma (HL) or non-Hodgkin lymphoma (NHL) and compared the biodistribution of ¹¹C-MET PET/CT with that of ¹⁸F-FDG PET/CT. Methods: Conducted under an investigational new drug authorization, we prospectively enrolled patients with newly diagnosed HL (n = 19) and NHL (n = 2) onto the Institutional Review Board-approved investigation of ¹¹C-MET PET/CT. After a minimum 4-h fast, patients received 740 MBq/1.7 m² (maximum, 740 MBq [20 mCi/1.7 m²; maximum, 20 mCi]) of ¹¹C-methionine intravenously. PET/CT was performed 5 min after injection from the vertex to thighs at 3 min per bed position. In a separate session, patients received 5.5 MBq/kg (maximum, 485 MBq [0.15 mCi/kg; maximum, 12 mCi]) of ¹⁸F-FDG with imaging initiated approximately 1 h after radiopharmaceutical administration. All studies were reviewed by consensus of 2 senior imaging specialists. The presence of metabolic activity on baseline studies was compared among 17 nodal groups. Results: Eighteen patients (11 male; median age, 15.2 y; age range, 9.5-22.6 y) comprised the study cohort. All had paired ¹¹C-MET PET/CT and ¹⁸F-FDG PET/CT studies at diagnosis. At baseline, 3 nodal groups demonstrating discordant metabolic activity by both ¹⁸F-FDG PET/CT and ¹¹C-MET PET/CT were Waldeyer's ring, paraaortic region, and the liver. All others were found to have concordant metabolic activity. Normal intense ¹¹C-MET uptake in the pancreas and liver reduced sensitivity for disease detection in these regions. At follow-up, 14 of 15 study pairs had concordant results. Conclusion:¹¹C-MET uptake is elevated in most regions involved with lymphoma at diagnosis and follow-up. Its utility in the abdomen is limited by uptake in normal structures.
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PMID:Comparison of ¹¹C-Methionine and ¹⁸F-FDG PET/CT for Staging and Follow-up of Pediatric Lymphoma. 2845 May 59

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