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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Malignant lymphomas constitute the third most common group of childhood cancers in the United States. Hodgkin's disease (HD) exhibits a bimodal age peak, with the first peak occurring in the 15-34-year age group. Nodular sclerosis is the most common histologic subtype of HD seen in children. The disease tends to be primarily supradiaphragmatic at presentation. Accurate staging is essential for determination of appropriate therapy. Staging laparotomy with splenectomy is indicated for those patients with clinically localized disease whose therapy may be altered by pathologic staging. Radiation therapy is curative in the great majority of patients with localized disease. Multimodality therapy has been employed with increasing success in patients with advanced disease. The late sequelae of therapy must be considered in the design of optimum therapeutic regimens. More than 90% of non-Hodgkin's lymphoma (NHL) in childhood can be grouped into one of three histologic subtypes: lymphoblastic, undifferentiated, and diffuse large cell type. Lymphoblastic lymphomas most commonly present with mediastinal involvement. The majority of nonlymphoblastic lymphomas arise within the abdomen. Because of the tendency of NHL for extralymphatic dissemination, systemic therapy is always required. Treatment is determined by stage and histology. Significant improvements in survival rates have resulted from the development of effective combination chemotherapy programs. Cure rates in excess of 90% can be expected in children with localized disease. The outlook for children with advanced disease of undifferentiated histology remains poor. The presence of central nervous system involvement at diagnosis is a particularly ominous sign.
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PMID:Malignant lymphomas in children and adolescents. 333 Feb 74

A 56-year-old man who had easy bruising, an enlarged left supraclavicular lymph node, and splenomegaly was diagnosed as having hairy-cell leukemia. Treatment consisted of splenectomy. Because of progressive lymphadenopathy in the following months, the patient required reevaluation. Examination of a lymph node biopsy specimen now revealed Hodgkin's disease, nodular sclerosis. This is the first pathologically confirmed case of hairy-cell leukemia coexisting with Hodgkin's disease.
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PMID:Hairy-cell leukemia associated with Hodgkin's disease: a case report. 397 51

Horner's Syndrome (ptosis, anisocoria, and anhydrosis) developed in a 22-year-old woman. A mediastinal mass was noted on chest x-ray. Further evaluation led to a diagnosis of Hodgkin's disease, nodular sclerosis type. Horner's syndrome is an unusual initial manifestation of Hodgkin's disease, and, in this case, it was due to oculosympathetic damage from mediastinal compression. Because the potential for cure is high in Hodgkin's disease, this diagnosis should be considered in patients presenting with Horner's syndrome.
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PMID:Horner's syndrome: an unusual presentation of Hodgkin's disease. 404 77

Eighty children aged less than 16 years with newly diagnosed Hodgkin's disease were treated between 1974 and 1982. Complete remission occurred in 95%, with actuarial five year overall survival of 94%, and relapse free survival of 82%: median follow up was 4.8 years. Sixty one children were staged clinically while 19 had staging laparotomies before treatment. Most received combined modality treatment with Ch1VPP chemotherapy (chlorambucil, vinblastine, procarbazine, and prednisolone) followed by irradiation of initial bulk disease. Nodular sclerosis predominated in both sexes, accounting for 60% of the total. Girls with stage IV disease, nodal sclerosis histology, and bulky mediastinal masses had a relatively poor prognosis. Ten children have relapsed, and three prolonged (6 to 7 years) second remissions have been observed. Four died of disease, and one from infection. Clinical staging, avoiding splenectomy, reduced the risk of serious infections. Our current policy is to treat stage IA disease with local irradiation and all other stages with chemotherapy, adding irradiation for bulky mediastinal disease.
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PMID:Chemotherapy and irradiation in childhood Hodgkin's disease. 654 91

Hodgkin's disease is relatively rare in children. The lymph node biopsies of 66 children with Hodgkin's disease were reclassified and discussed in relation to age and sex. The youngest patient was a 2-year-old boy. Mixed cellularity was the most common histologic type (37.9%-25 cases) showing a slight preponderance of boys (14 cases). Nodular sclerosis comprised 31.8% (21 cases) and the lymphocyte predominant type was found in 19.7% (13 cases) in contrast to the low incidence of the lymphocyte depletion type (6.1%-4 cases). At the age of 2 to 10 years Hodgkin's disease prevailed in boys. Our results are discussed regarding the findings of the literature.
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PMID:[Lymphogranulomatosis in childhood]. 666 10

A series of 182 patients with Hodgkin's disease, diagnosed between January 1973 and December 1978 was used to identify prognostic factors with special reference to age. There were 118 men and 64 women (mean age, 47 years; r = 15-92). During the same period 57 elderly patients who were never referred, were reported to the Local Cancer Registry. The diagnosis had been established shortly before death or at autopsy. The 182 patients under study were evenly distributed in Stages I-IV. Nodular sclerosis (38%) and mixed cellularity (38%) were the most common histologic subtypes. The 5-year survival probability estimate was 28% in patients above 50 years as compared to 74% in the remainder. Survival was significantly better in patients with Stage I-II disease and lymphocyte predominance/nodular sclerosis histopathology. Age was the main prognostic factor in the whole series as well as in patients older than 50 years. However, in young patients advanced clinical stage and B-symptoms were related to a poor prognosis. Biologic indicators such as ESR, hemoglobin and albumin were intimately linked to the extent of disease and did not add prognostic information besides that given by the clinical stage. It is concluded that the prognosis in elderly remains poor and appears to be partly unrelated to those factors which determine the prognosis in the young, assumingly reflecting a depressed host-response and/or a decreased tolerance to intensive treatment.
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PMID:Prognostic factors in Hodgkin's disease with special reference to age. 669 8

A large number of histologic and clinical parameters were assessed, tabulated and intercorrelated in 659 patients with Hodgkin's disease evaluated and treated at Stanford University Medical Center. Nodular sclerosis was the most common pattern (60%) and also had the best total survival, but lymphocyte predominance had the best relapse-free survival. While a number of histologic parameters showed a significant correlation with relapse-free survival, multivariate analysis showed that age, stage, and treatment were relatively more important. Of the histologic parameters, only the number of lymphocytes, fibroblasts, and amount of sclerosis remained significant after multivariate analysis. The positive correlation of sclerosis, negative correlation of the number of fibroblasts and lack of correlation of lacunar cells with relapse free survival in patients with nodular sclerosis suggested that the type of mesenchymal reaction was of prime importance in determining prognosis in that form of Hodgkin's disease. The number of lymphocytes did not independently affect prognosis in patients with nodular sclerosis but did so for the entire group. The cellular phase of nodular sclerosis was found to have an overall survival and some clinical features more akin to mixed cellularity Hodgkin's disease.
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PMID:Hodgkin's disease: a clinicopathologic study of 659 cases. 707 84

The Rye histologic classification of Hodgkin's disease has been applied retrospectively to a series of 78 previously untreated cases of Hodgkin's disease. The patients have been followed for periods varying from 1 to 12 years. Mixed cellularity was the most common histologic type. Nodular sclerosis had an intermediate frequency, and lymphocytic predominance and lymphocytic depletion showed the lowest incidence. The sex incidence showed a male predominance in all histologic types except the nodular sclerosis, where prevalence of females was noted. The study confirms the better prognosis of the lymphocytic predominance and nodular sclerosis in comparison with the poor prognosis of the mixed cellularity and the very poor prognosis of the lymphocytic depletion. Nodular sclerosis presented with higher incidence in the mediastinum; it occurred mainly in young females and it exhibited a relatively good prognosis, findings which support the accepted view that nodular sclerosis comprises a distinct clinical and biological type of the disease. A marked difference in the survival rates in Stages I and II as compared to those of Stages III and IV was found.
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PMID:Hodgkin's disease in Greece: a retrospective clinicopathologic study of 78 cases. 707 92

During the course of Hodgkin's disease there is a low incidence of clinical manifestations of liver involvement: less than 15% of the patients present jaundice at some time during the evolution of their disease. The initial manifestation of Hodgkin's disease as an hepatic illness is a rare event. Two such cases are herein reported. The first patient was a 68 year-old male with a febrile illness of one month duration who 15 days before admission presented painless jaundice, dark urine, and discolored stools. The clinical work-up pointed to the possible existence of an extrahepatic cholestasis. At laparotomy a normal biliary tree was found, and surgical liver biopsy disclosed severe tissue cholestasis and a granulomatous portal reaction constituted by white blood cells, eosinophiles and histiocytes, most of them atypical and some showing features of Reed-Sternberg cells. The second patient was a 21 year-old male with a febrile illness of four months duration who developed jaundice and progressive mental obtundation one week before admission. The biochemical studies demonstrated severe pancytopenia and signs of advanced liver failure. Percutaneous liver biopsy disclosed a normal hepatic architecture and the presence of numerous atypical histiocytes in the portal areas. Lymphography showed sizeable pelvic and paraaortic lymph nodes. Subsequent laparotomy for lymph node biopsy confirmed the diagnosis of Hodgkin's disease, nodular sclerosis type. The authors suggest that hepatic Hodgkin's disease must be considered in the differential diagnosis of any febrile illness with jaundice.
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PMID:[Hodgkin's disease presenting as an hepatic disease. Report of two cases (author's transl)]. 725 32

A patient with chronic adult-onset Gaucher's disease is described. The diagnosis was based on the finding of typical Gaucher cells in the spleen, liver and bone marrow associated with deficiency of glucocerebrosidase. The patient also had Hodgkin's disease, nodular sclerosis type, stage III. The patient is alive and relatively well six years after presentation, having been treated with a combination of chemotherapeutic regimens. Previously reported cases of Gaucher's disease concurrent with Hodgkin's disease are reviewed.
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PMID:Gaucher's disease associated with Hodgkin's disease. 736 36


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