Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-one cases of large, B-cell lymphoma with an unusually high content of reactive T lymphocytes are described in this report. Fifteen patients presented with lymphoma in nodal sites and six patients presented with lymphoma in extranodal sites. With two exceptions, all patients were more than 50 years of age. The male to female ratio was 1:2. Histologically, isolated to small groups of large lymphoid cells were intermingled with many small lymphocytes. The large cells were neoplastic and exhibited B-lineage markers; immunoglobulin light chain restriction could be demonstrated in two thirds of the cases. There was a rich infiltrate of immunophenotypically mature T lymphocytes that comprised more than 50% of the cellular population. The T lymphocytes ranged from small cells with dark, round nuclei to slightly larger cells with elongated, irregular nuclei. There were occasional medium-sized blastic cells. There was also a variable infiltrate of histiocytes with or without epithelioid features, eosinophils and plasma cells, and increased vascularity. The peculiar morphologic features were also reproduced in other sites in the four patients for whom additional histologic materials were available for examination. We postulate that the abundance of T cells results either from a florid host reaction or from cytokine secretion by the neoplastic B cells, attracting T cells to the vicinity. The morphologic and immunologic features mimic those of a variety of benign lymphoproliferative diseases, angioimmunoblastic lymphadenopathy and lymphomas arising in angioimmunoblastic lymphadenopathy, peripheral T-cell lymphoma, secondary B-immunoblastic lymphoma, and Hodgkin's disease. Careful morphologic evaluation and immunophenotypic studies using leukocyte antibodies reactive in paraffin-embedded sections are of great assistance in determining a diagnosis.
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PMID:Large B-cell lymphomas with a high content of reactive T cells. 259 44

The diagnosis of peripheral T-cell lymphoma (PTCL) is difficult. This entity can be misdiagnosed as Hodgkin's disease or a reactive process such as nonnecrotizing granulomatous lymphadenitis or it can present a problem in lymphoma classification. Fine-needle aspirates from 13 patients with histologically proven PTCL were evaluated by cytology, immunochemistry, and flow cytometry. Of the 13 patients with PTCL, initial cytologic diagnoses were atypical lymphocytic infiltrate (2), mixed-cell lymphoma (6), mixed-cell lymphoma with associated histiocytes (2), large cell lymphoma (2), and small cell lymphoma (1). Surface marker studies were performed on cytospin preparations. Antibodies against cytotoxic-suppressor (Leu-2a) and helper-inducer (Leu-3a,b) antigens were used in 11 cases. Ten lymphomas demonstrated helper phenotype and one showed phenotypic heterogeneity in two different sites. The most prominent cytologic features of PTCL were a variable combination of small, intermediate, and large lymphoid cells with irregular nuclei, presence of epithelioid histiocytes, and atypical mononuclear cells. Flow cytometry studies showed a diploid stem line with intermediate proliferative activity (mean S-phase of 6.7%) in most cases, despite the clinical aggressiveness of this neoplasm.
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PMID:Fine-needle aspiration cytology of peripheral T-cell lymphoma. A cytologic, immunologic, and cytometric study. 264 4

A peripheral T-cell lymphoma with a high content of epithelioid cells--an entity that reveals morphologic and clinical characteristics resembling those seen in angioimmunoblastic lymphadenopathy (AILD)--was separated from lymphoepithelioid cell lymphoma (Lennert's lymphoma, or LeL); it was considered a variant of the AILD type of peripheral T-cell lymphoma (AILD-PTCLep). A histologic evaluation of 135 lymph node biopsies from 98 patients with AILD-PTCLep showed that AILD-PTCLep and LeL share certain features, but there are also differences between the two. A finding common to both lymphomas was the mixture of neoplastic T-lymphocytes and a large number of epithelioid cells, which accumulated mostly in small, poorly defined clusters. Additionally, typical Sternberg-Reed and Hodgkin cells as well as giant cells resembling them were observed only rarely in either of these lymphomas. In contrast to LeL, AILD-PTCLep showed a great increase in follicular dendritic cells, which were sometimes identifiable in routine slides as so-called burned-out germinal centers. In AILD-PTCLep, the number of small vessels (predominantly epithelioid venules) and fibers is also usually greatly increased, whereas in LeL this is not the case, or the increase is only slight. Hypocellular and lymphocyte-depleted areas and PAS-positive intercellular material were seen in AILD-PTCLep (18% and 34%, respectively), but not in LeL. Large numbers of eosinophils, plasma cells and plasma cell precursors, and diffuse neoplastic infiltration of the capsule and extranodal tissue were observed much more commonly in AILD-PTCLep. Corresponding to these differences in the histologic pictures are differences in the clinical pictures. Hyperimmune phenomena (pruritus, skin rash, hemolytic anemia, allergy to antibiotics) and hypergammaglobulinemia were much more common in AILD-PTCLep than in LeL. Allergy to chemotherapeutic agents was observed only in AILD-PTCLep patients. Carcinomas were observed as a second neoplasm in 11% of the patients with AILD-PTCLep, but not at all in LeL. The similarities between the two lymphomas include the age and sex distribution (peak in the seventh decade and slight predominance of the male sex) and a similar median survival time. Another similarity is the possibility that the disease will develop into a large-cell malignant lymphoma. This was observed in 13% of the cases of AILD-PTCLep and 8% of the cases of LeL.
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PMID:Angioimmunoblastic lymphadenopathy--type of T-cell lymphoma with a high content of epithelioid cells. Histopathology and comparison with lymphoepithelioid cell lymphoma. 264 76

This review article describes the MAC and MACISH (morphology, antibody, chromosomes, in situ hybridization) methods, which allow the examination of numerical chromosome abnormalities of morphologically and immunologically classified interphase or mitotic cells. Results of studies using these methods indicate that the proportion of mitotic B cells is the same in phytohemagglutinin- and pokeweed mitogen-stimulated lymphocyte cultures, that the proportions of different cell lineages vary greatly after short-term culture of bone marrow cells, that only B cells have a clonal chromosome abnormality in B-cell type chronic lymphatic leukemia and lymphoma, that a clonal chromosome abnormality of patients with T-cell lymphoma may occur in a different T cell subpopulation or at a different maturation stage in certain lineages while B cells show a normal karyotype, that only Reed-Sternberg cells have a clonal chromosome abnormality in Hodgkin's disease, and that in a proportion of patients with acute myeloid leukemia not only a granulocytic-monocytic lineage but also erythrocytic and megakaryocytic lineages show a clonal chromosome abnormality.
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PMID:Immunophenotyping of aneuploid cells. 267 Jan 94

Interleukin 2 and its receptor have emerged as a central control system in the regulation of the immune response and the proliferation of T cells, B cells, and macrophage. IL-2 receptor expression is strongly associated with several forms of human lymphoproliferative disease including adult T-cell leukemia-lymphoma, hairy cell leukemia, Hodgkin's disease, and peripheral T-cell lymphoma in which it may play a pathogenetic role. IL-2 receptor expression may also play a role in some B-cell non-Hodgkin's lymphomas and histiocytic proliferations. Recent discoveries in immunology and advances in biotechnology have opened therapeutic possibilities for IL-2 including the use of anti-Tac monoclonal antibodies and immunoconjugates for the therapy of Tac-positive lymphoproliferative disease, the use of anti-Tac monoclonal antibodies as novel immunosuppressants, and the use of genetically engineered recombinant IL-2 and activated autologous lymphocytes in the adoptive immunotherapy of cancer. Therapeutic and diagnostic applications of IL-2 continue to be defined.
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PMID:Interleukin receptors in lymphoid lesions. Relevance to diagnosis, biology, and therapy. 267 80

We studied 123 lymph node biopsies from 99 patients with Hodgkin's disease, mixed cellularity type, with a high content of epithelioid cells (HDMCep), by light microscopy using conventional histologic and immunohistochemical techniques. The cellular composition and histologic structure, which are described in detail, serve as a basis for discriminating HDMCep from similar lymphomas with a high content of epithelioid cells, especially from lymphoepithelioid cell lymphoma (Lennert's lymphoma, LeL) and angioimmunoblastic (LgX) type of peripheral T-cell lymphoma with a high content of epithelioid cells (AILD-PTCLep). In all lymph nodes from patients with HDMCep, the nodal architecture was effaced. In 11% it was partially replaced by a massive infiltration of epithelioid cells and small to medium-sized lymphoid cells occurring in varying proportions with some immunoblasts. In all biopsy specimens, some typical Sternberg-Reed (SR) and Hodgkin (H) cells were found. Plasma cells and plasma cell precursors were present in all biopsy specimens; in most cases, they were sparse to moderate in number. Eosinophils were always present; half of the biopsy specimens had rather large numbers of them. Formation of granulomas like those seen in sarcoidosis was noted in 7% of the specimens. Increased vascularity and an increased number of fibers were found in 53% and 63% of the biopsy specimens, respectively. Necrosis was seen in 20% of the specimens. Immunohistochemically in 30 of 67 (45%) biopsy specimens, giant cells stained positively for the granulocyte-specific monoclonal antibody 3C4 (approximately CD15). Plasma cells and plasma cell precursors in all 70 specimens exhibited a polyclonal Ig pattern. A comparison of the main clinical and laboratory data in these three entities reveals both similarities and differences. HDMCep--defined as a special variant of Hodgkin's disease, mixed cellularity type (HDMC)--marks apparently the border between Hodgkin's disease and non-Hodgkin's lymphomas.
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PMID:Cytohistologic and immunohistochemical findings in Hodgkin's disease, mixed cellularity type, with a high content of epithelioid cells. 268 42

Peripheral T-cell lymphoma is the most common type of T-cell lymphoma seen in adults in the United States. Clinical data were reviewed from 134 cases of peripheral T-cell lymphoma diagnosed in three centers. The median age of the patients was 57 years (range, 4-97 years), 59% were male, and 36 patients (27%) had a history of a preceding disorder of the immune system. The tumors were grouped histologically into large cell (43%), mixed large and small cell (40%), and small cell (17%). The stage at diagnosis was I (7%), II (21%), III (22%), and IV (50%). B symptoms were present in 57%. The most frequent sites of extranodal involvement were bone marrow (35%), skin (13%), and lung (11%). Eighty patients were treated with a multiagent chemotherapy regimen with proven curative potential in aggressive non-Hodgkin's lymphomas and the remainder of the patients received less intensive chemotherapy (36 patients), radiotherapy (nine patients), or no treatment (nine patients). Fifty percent of the intensively treated patients achieved complete remission and the actuarial 4-year survival was 45%. However, the 4-year, disease-free survival in patients with Stage IV disease was only 10%. Although peripheral T-cell lymphomas appeared similar in many ways to their B-cell counterparts, disease-free survival by stage was low and patients with Stage IV disease had an especially poor outlook.
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PMID:Peripheral T-cell lymphoma. 278 76

A 47-year-old woman, known to have coeliac disease, developed bouts of fever, up to 39 degrees C, with loss of weight and treatment-resistant diarrhoea, as well as swelling of the submandibular, axillary and inguinal lymph nodes. Tests revealed a pancytopenia (haemoglobin 8.8 g/dl, leucocytes 500/microliter, platelets 19,000/microliter), and a reduction of the Quick value to 39%. Computer tomography demonstrated extensive abdominal lymphomas. The patient's general condition quickly deteriorated, hypoproteinaemia developed (total protein 4.6 g/dl) with peripheral oedema, ascites and pleural effusion. She died before the suspected diagnosis of coeliac disease-associated malignant lymphoma could be confirmed. Autopsy demonstrated a highly malignant, pleomorphic, primary abdominal non-Hodgkin lymphoma, immunohistologically a T-cell lymphoma.
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PMID:[T-cell lymphoma associated with sprue]. 278 67

T-cell lymphoma may involve the CNS as either a primary or secondary neoplasm. This report describes 8 patients with either primary or secondary T-cell malignancies in the CNS. Five patients presented with symptoms and signs of CNS disease that included seizures, visual impairment, cranial nerve palsies, sensory and motor deficits, gait ataxia, and paraparesis. Three of them had primary parenchymal CNS lymphoma, and 2 had epidural lymphoma that originated in adjacent bone marrow. Three patients were neurologically asymptomatic, but had leptomeningeal tumor and focal parenchymal infiltration at postmortem examination. Histologically, 4 lymphomas were large cell, 3 were mixed large and small cell, and 1 could not be classified by the working formulation for non-Hodgkin's lymphomas. The clinical and pathologic manifestations of T-cell lymphoma in the CNS may be diverse. This report demonstrates that neurologic abnormalities may be the presenting signs of either primary CNS or systemic T-cell lymphoma.
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PMID:T-cell lymphoma in the CNS: clinical and pathologic features. 278 32

The distinction between peripheral T-cell lymphoma (PTCL) and Hodgkin's disease (HD), particularly HD of the mixed cellularity subtype (HDMC), can be difficult at times using current morphologic criteria. This study assessed the value of using mitotic activity and pericapsular invasion in discriminating between the two diseases. Mitotic activity was evaluated in 64 cases of HDNS (nodular sclerosis), 51 of HDMC, 14 of HDLP (lymphocyte predominant), 7 of HDLD (lymphocyte depleted), and 28 cases of PTCL. The number of mitoses in random high-power fields (hpf) was counted independently by two observers. Interobserver agreement on mitotic counts was achieved with a 0.97 coefficient of correlation. Statistical analyses demonstrated significant differences in mitotic counts between HD and PTCL (p less than 0.01), but not within the subtypes of HD. A value of greater than 20 mitoses/20 hpf was obtained in only 10% of HD, in contrast to 70% of PTCL. The mitotic rate was greater than 40/20 hpf in 43% of PTCL, but in no case of HD. In addition, perinodal extension of disease was a significant differentiating feature between PTCL and HD, especially HDMC (p less than 0.001). There was also a significant difference in the age distribution between patients in the two disease groups, with PTCL being seen more frequently in the older age group. The results of this study confirm that counting of mitoses is reproducible, and that mitotic activity and the presence of pericapsular disease are two additional morphologic criteria that are helpful in making the distinction between HD and PTCL.
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PMID:Differential diagnosis between T-cell lymphoma and Hodgkin's disease: the value of mitotic counts and pericapsular infiltration. 278 14


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