Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Presentation is made of the ocular complications of AIDS which were observed in the ophthalmologic clinic of the University Hospital in Zurich from 1986 to 1991. Besides cotton-wool spots, CMV-retinitis is the most frequent and best known infectious complication. In all other infections, diagnosis is most difficult, because it could never be supported by histological examination. Presentation is made of some cases of acute retinal necrosis, toxoplasmosis, cryptococcosis, candida, and of some cases of uveitis with unknown etiology. Furthermore we present one intraocular non-Hodgkin lymphoma, some suspicions of Kaposi's sarcoma and some neurologic disturbances of central origin.
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PMID:[Ocular complications of AIDS. Diagnostic problems]. 161 55

This paper reviews the modalities of involvement of the visual function in patients with primary non-Hodgkin's lymphomas. They include the lymphomatous uveitis, the invasion of the orbital cavities and cavernous sinuses, and the involvement of the optic nerves, chiasm and optic tracts by lymphomatous lesions. Two cases of primary non-Hodgkin's lymphomas with visual disturbances are reported and the different mechanisms of visual pathway damage and clinical troubles are discussed from a large review of the pertinent literature.
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PMID:Visual involvement in primary non-Hodgkin's lymphomas. 216 92

The Vogt-Koyanagi-Harada (VKH) syndrome, a disease of unknown origin, characterized by inflammation of the uveal tract, retina and meninges, was observed in a patient with Hodgkin's disease (HD) who had been treated with chemotherapy and radiotherapy. Ten years later the patient developed a cluster of neurological symptoms and signs (fever, pain, bilateral hypoacousia, dizziness, uveitis and psychiatric disorder) which were initially interpreted as a relapse of HD. The diagnosis of VKH syndrome was thereafter suspected from the clinical findings, response to therapy and further evolution. During the follow-up (14 months) the patient showed a varying course; hypoacousia remained unaltered while uveitis recurred and only a partial improvement was obtained by immunosuppressive therapy.
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PMID:A case of Vogt-Koyanagi-Harada syndrome in a patient affected by Hodgkin's disease. 276 Jun 48

Thirty-eight patients with advanced Hodgkin disease were treated with a combination of cyclophosphamide, vinblastine, procarbazine, and prednisone (CVPP) from 1970 to 1973 and followed prospectively. Long-term results after a median follow-up of 14 years are reported. Seventeen of the 28 complete responders (61%) survived more than 10 years from the initiation of chemotherapy. At the current time, 12 of the 28 patients (43%) are continuously disease-free 12.8 to 15.3 years after completing induction chemotherapy. Two additional patients are alive in third and fifth remissions. All relapses occurred within 5.5 years of completing induction chemotherapy. Late complications included sterility, aseptic osteonecrosis, severe pulmonary fibrosis, and chronic uveitis. Four of the complete responders (14%) developed second neoplasms, including acute myelogenous leukemia, non-Hodgkin lymphoma and small cell carcinoma of the lung. All second malignancies were fatal and developed 5-13 years after initiation of induction chemotherapy. Our data confirm that cure is possible with alternative regimens to MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone).
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PMID:Chemotherapy with cyclophosphamide, vinblastine, procarbazine, and prednisone (CVPP) for Hodgkin disease: fourteen-year follow-up results. 341 72

A poorly understood association between Hodgkin's disease and noncaseating granulomas has been well documented in all stages of the lymphoma. Characteristically, the granulomas are found within liver, spleen, lymph nodes, and bone marrow. The following case report describes a 21-year-old woman with Stage 1-A nodular sclerosis Hodgkin's disease who had both multiple noncaseating granulomas in her spleen and an abdominal lymph node, as well as bilateral granulomatous uveitis.
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PMID:Hodgkin's disease and granulomatous uveitis. 409 80

A 57 year-old man developed a left posterior uveitis, without obvious aetiology and unresponsive to antibiotherapy and steroids. Nine months later, a lymphoma of the left parieto-occipital area was discovered. An immunological study detected a peripheral blood T lymphocytes deficiency, a B lymphocytes excess and a monoclonal gammopathy (IgM lambda). The latter abnormality disappeared one month after neurosurgery. Tumor cells were of the B lymphoid type with lambda light chain only. Brain irradiation and chemotherapy first improved neurological signs but right uveitis developed. The patient died 22 months after the first ophthalmological symptoms. The association of primary non Hodgkin brain lymphoma (PNHBL) (reticulum-cell sarcoma) with uveitis has already been described in 51 other cases in the literature. Two possibilities are considered: first, uveitis appears with or follows the neurological signs (NS): the prognosis is the same as that of PNHBL alone; second, uveitis appears before the NS: the prognosis is better and can be improved by brain and ocular irradiation. The immunological abnormalities are discussed. T lymphocytes deficiency and B lymphocytes excess have already been described but a monoclonal gammopathy is a more unusual finding.
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PMID:[Uveitis and cerebral lymphoma]. 643 62

Non-Hodgkin's lymphomas can simulate uveitis. Two patients with non-Hodgkin's lymphoma had anterior uveitis. Material was obtained from the enucleated eye in case 1, and from an inguinal lymph node in case 2. Immunologic evaluation of this material led to the diagnosis of peripheral T-cell lymphoma in both cases. Immunologic evaluation is useful in the examination of patients with lymphoma.
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PMID:Ocular involvement by a peripheral T-cell lymphoma. 660 42

Ocular manifestation in non-Hodgkin lymphomas are rare and they evolute as non-specific uveitis. The paper presents the case of a 8-year-old boy presenting iridic nodular lesion which had appeared in the evolution of a non-Hodgkin malignant lymphoma. Various ocular manifestations which may evolute with a non-Hodgkin malignant lymphoma are also presented.
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PMID:[Ocular manifestations in non-Hodgkin's lymphomas]. 752 Feb 76

A patient with non-Hodgkin lymphoma with low grade malignancy complained of gradual visual loss. Symmetric multiple deep retinal yellow dots were disseminated in both fundi. The patient developed progressive papilledema associated with further decreasing visual acuity. Other signs of uveitis were absent. A chorioretinal biopsy confirmed the intraocular lymphomatous involvement. Cerebrospinal fluid revealed abnormal lymphocytes and local Ig-M production thus proving the lymphomatous meningeal involvement.
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PMID:Chorioretinal biopsy in the diagnosis of intraocular lymphoma: a case report. 789 59

Large-cell (non-Hodgkin's) lymphoma may occur in the eye as a cellular infiltrate in the vitreous, uveal tract (choroid), retina, or optic nerve. Lymphomatous involvement may be limited to the eye but also is frequently associated with lesions of the central nervous system. Ocular involvement may precede involvement of the central nervous system by months or, in some cases, years. Ocular large-cell lymphoma is bilateral in approximately 80% of cases but often is asymmetric. The mean age of patients with ocular large-cell lymphoma is 60 years, and women are affected almost twice as often as men. Intravitreal large-cell lymphoma may manifest as an infiltrate of large glassy-gray cells or clusters of cells, and it may mimic uveitis or other inflammatory and infectious conditions of the eye. The diagnosis is based on cytologic and immunocytochemical studies of a vitreous biopsy specimen obtained by aspiration or by vitrectomy through the pars plana. Advances in irradiation of the eyes and the central nervous system, supplemented with corticosteroids and intrathecally and intravenously administered chemotherapeutic agents, have resulted in improvement of the dismal prognosis for patients with large-cell lymphoma.
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PMID:Intravitreal large-cell lymphoma. 841 51


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