Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Since 1950 to 1968 in the Nikolaevsk Province Oncological dispensary 1006 breast cancer patients were radically operated upon. 943 patients were followed up, primary multiple tumors being observed in 52 of them (5.5%). Primary multiple tumors in stage I were noted in 2.3% of cases, in stage II--in 7.7%, in stage III--in 4.2%. A second tumor appeared in different terms following the cure of mammary gland cancer: in the other gland--in 28 cases, in the uterus--in 7, in the stomach--in 4, in ovaries--in 1, 7 patients developed skin cancer, 1--cancer of the lower lip and 2--lymphogranulomatosis.
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PMID:[Breast cancer in combination with other malignant tumors]. 43 18

Mortality among female, black male and white male salaried employees in Akron, Ohio, is described. Standard mortality ratios for all causes of death are: females, 78: black males, 62: white salaried males, 65. Excess deaths from cancer occurred in females: uterus, bladder, brain and multiple myeloma; in black males: Hodgkin's disease; and in white salaried males: bladder and lymphatic. Also, proportional mortality among white male employees of six non-Akron plants is reported. Excess deaths from cancer include brain and lymphatic and hematopoietic.
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PMID:Mortality among rubber workers. II. Other employees. 94 35

Pelvic irradiation for the treatment of Hodgkin disease in premenopausal women invariably results in ovarian failure unless the ovaries are shielded. Oophoropexy by laparotomy has been used previously to move the ovaries away from the pelvic nodal areas. We have designed, and used in one patient, a new laparoscopic technique that can be performed as an outpatient procedure and that allows radiation therapy to begin immediately. Oophoropexy was performed laparoscopically with placement of sutures through the utero-ovarian ligaments and posterior uterus. Surgical clips were placed to help identify the position of the ovaries postoperatively.
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PMID:Laparoscopic oophoropexy for preservation of ovarian function before pelvic node irradiation. 138 64

Ovarian transposition in adults has been shown to protect ovarian function in about 60% of cases by reducing ovarian exposure to less than 4 to 7 Gy. We therefore evaluated the effect of ovarian transposition during childhood or adolescence. Eighteen girls had ovarian transposition performed at a mean (+/- SEM) age of 9.4 +/- 1.2 years (range, 1.2 to 16 years). Twelve were prepubertal and six had menstruated at the time of ovarian transposition. The initial abnormalities were Hodgkin disease (5 cases), iliac Ewing sarcoma (3), medulloblastoma (2), ovarian seminoma (1), and vaginal or uterine tumor (7). The irradiation was external in 11 cases and local by vaginal curietherapy in 7 cases. Fifteen girls received chemotherapy. The ovarian transposition was bilateral in 15 patients and unilateral in 3 cases; in the latter the other ovary had been destroyed by the tumor or by abdominal irradiation. Ovaries were placed just below the iliac crest (15 cases) or posterolateral to the uterus (3); thus, the calculated ovarian radiation dose was up to 9.5 Gy. At the time of evaluation (8.6 +/- 0.9 years after ovarian transposition), 16 girls had menstruated and 2 remained amenorrheic because of major lesions of the vagina and uterus caused by the vaginal curietherapy. Basal plasma gonadotropin values were normal. Ovulation was documented in seven cases. Two pregnancies occurred. Complications of ovarian transposition were present in four patients: intestinal occlusion, dyspareunia, functional ovarian cysts, and pelvic adhesions with tubal obstruction. We conclude that ovarian transposition, performed before abdominopelvic irradiation during childhood, can preserve ovarian function. Longer follow-up is required to assess the risk of ovarian dystrophy because of vascular lesions or chemotherapy.
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PMID:Preservation of ovarian function by ovarian transposition performed before pelvic irradiation during childhood. 144 49

Between 1956 and 1990, 775 women were treated for Hodgkin's disease at The University of Texas M.D. Anderson Cancer Center. Of these, 25 (3.2%) were pregnant at diagnosis. Seven of these women were in the first trimester, 10 in the second, and eight in the third. Prior to treatment, three women in the third trimester had normal deliveries, and six patients in the first trimester had abortions. Sixteen patients received radiotherapy for supradiaphragmatic presentations during their pregnancies. All these patients had nodular sclerosing Hodgkin's disease: Two had clinical stage IA presentations and 14 had clinical stage IIA. In two patients radiotherapy (35 Gy) was limited to the neck, three patients were treated definitively to the neck and mediastinum (40 Gy), and 11 patients received mantle irradiation (40 Gy). Four to five half-value layers of lead were used to shield the uterus during radiotherapy. The dose to the fetus was estimated individually in nine patients, using a combination of an Alderson-Rando and a water phantom. The estimated total dose to the mid-fetus ranged from 1.4 to 5.5 cGy for treatment with 6 MV photons, and from 10 to 13.6 cGy for Cobalt 60. All 16 patients subsequently delivered full-term, normal infants. Following delivery, all of the patients had further staging procedures; eight received additional treatment. Subsequently, the disease relapsed in four patients; two eventually died of Hodgkin's disease. The 10-year determinant and overall survival rates were 83% and 71%, respectively. Currently, all offspring are physically and mentally normal, and none has developed a malignancy. Radiotherapy is an appropriate initial treatment for supradiaphragmatic presentations of Hodgkin's disease during the second and third trimesters of pregnancy, provided special attention is paid to treatment and shielding techniques. The outcome for women treated with irradiation for clinical stage I and II Hodgkin's disease during pregnancy has not been shown to be adversely affected by pregnancy, and after the first 8 weeks of gestation, the risk to the fetus appears to be minimal.
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PMID:Radiotherapy during pregnancy for clinical stages IA-IIA Hodgkin's disease. 158 64

Cancer is the second cause of mortality in Chile: 12,000 deaths and 27,000 admissions were registered during 1982. Gastric and pulmonary cancer account for the highest mortality rates (23.2 and 9.7/100,000). Cancer prognosis has improved in thyroid, uterus and testes cancers, melanoma, Hodgkin's Disease etc, with 67 to 92% 5-year survival rates, while results are not as good in lung, gastric, colorectal, kidney, pancreas, etc, with only 3 to 52% 5-year survival rates. Treatment failure is attributed to cellular mutations and early metastases. At present, surgery is less aggressive and is associated to radiotherapy and chemotherapy; megavoltage radiation equipment and the use of radiosensitizers allow double radiation dose; chemotherapy complications are avoided with hematopoietic growth factors. It is possible to improve the prognosis of lung cancer avoiding the use of tobacco and of colorectal cancer reducing fats in the diet of these pts. Early detection and better chemotherapy have improved the prognosis of breast and uterus cancer. With these measures a 20 to 50% reduction in cancer rates is expected in the USA for the year 2000. Their application is urgent in our country.
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PMID:[Present status of cancer treatment]. 184 13

The second European Atlas of Avoidable deaths, which will be shortly issued, concerns the period 1979-83 for Italy. The causes of deaths included were: tuberculosis, neoplasms of the cervix uteri and those of the uterus with no specified site, Hodgkin's disease, chronic rheumatic heart disease, hypertensive and cerebrovascular disease, childhood respiratory infections, asthma, appendicitis, abdominal hernia, cholecystitis and cholelithiasis, maternal and perinatal deaths. In Italy marked excesses for cholecystitis-cholelithiasis, Hodgkin's disease, hypertensive and cerebrovascular disease and perinatal mortality were observed. A remarkable decrease was observed in comparison with the first Atlas (1974-78); but the European countries generally maintained the differences amongst them and their rank. Proposals to assess the causes of the observed differences are suggested (death certificate quality evaluation studies, case-reference studies, cohort studies) and the role of confidential enquiries is discussed.
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PMID:[Avoidable deaths in the evaluation of the performance of health services. II. European Atlas of avoidable deaths: initial data and several reflections]. 215 27

Fourteen cases of lymphoma involving urogenital systems (10 kidney, 1 bladder and 3 female genital system) were studied as to their image manifestations. In all 10 kidney cases of diffuse non-Hodgkin's lymphomas, multiple parenchymal nodules were found in 4, single mass in 3, perirenal involvement (Halo sign) with multiple nodules in the kidney in 2 and diffuse infiltration in the other one. The main ultrasonographic findings were hypoecho solid lesions without sharp margins. On pre-contrast CT scans, most of the lesions had similar attenuation as the normal renal parenchyma. After contrast, the normal parenchyma was enhanced much more than the lesion. The lesion may be missed if scan was performed without contrast enhancement. In the 3 cases with involvement of the female genital organs, the involved uterus and cervix were obviously enlarged and vaginal wall became thickened as hypoecho in B-ultrasound. Multi-planned scanning ultrasound is very helpful in showing the relation between pelvic mass and uterus.
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PMID:[Computed tomography and ultrasonography of lymphoma involving urogenital systems]. 227 35

Malignant lymphomas concern the female genital tract in 30% of cases. The majority (more than 90%) are non-Hodgkin lymphoma, involving in order of frequency, ovary (49%), uterus (29%), Fallopian tubes (11%), vagina (7%), vulva (4%). So a primary vulvar localization seems to be quite unusual; in fact only 5 cases have been reported since 1937 up to now. We report a case of vulvar non-Hodgkin lymphoma we observed in our Institute.
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PMID:Non-Hodgkin lymphoma: a rare primary vulvar localization. 237 17

We calculated 5-year crude and relative survival rates, by age and sex, for patients in Alberta in whom cancer was diagnosed between 1974 and 1978. Cancers with low overall 5-year relative survival rates (less than 35%) included stomach cancer, cancer of the pancreas, lung cancer, brain cancer, multiple myeloma and myeloid leukemia. Cancers with high overall 5-year relative survival rates (more than 70%) included melanoma, breast cancer, cancer of the uterus, cancer of the bladder and Hodgkin's disease. Five-year relative survival rates were generally lower in the highest age group (75 years or more). A strong inverse relation between age and survival was noted for brain cancer, non-Hodgkin's lymphoma, Hodgkin's disease and myeloid leukemia.
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PMID:Survival rates among patients with cancer in Alberta in 1974-78. 337 May 94


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