Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thallium-201 was given to 71 patients with various pulmonary diseases. Positive uptake was noted in primary malignant neoplasms and also in 6 cases of Hodgkin's lymphoma. No uptake was seen in pulmonary diseases other than active tuberculosis. A disadvantage is the high myocardial accumulation of this radionuclide which impairs proper visualization of paracardiac neoplasms.
 ...
PMID:Thallium-201 as a positive indicator for lung neoplasms: preliminary experiments. 98 33

The authors report 4 cases of chronic pericardial effus-ons appearing several months after high dose mediastinal irradiation for Hodgkin's disease. They describe their clinical characteristics and course. The difficulties of differential diagnosis are mentioned, in particular recurrence of malignancy and tuberculosis. They stress the reserved long term prognosis and the absence of any specific therapeutic approach. The increasing use of madiastinal radiotherapy suggests that the incidence of such manifestations will increase.
 ...
PMID:[Pericardial effusions and mediastinal radiotherapy. 4 cases]. 112 75

Clinico-roentgenological findings in 148 patients with an axillary location of tumor are described. Thirty two of them had benign tumors (lipomas, fibromas, angiomas), 8-malignant (sarcomas), 57-systemic diseases associated with increased lymph nodes (lymphogranulomatosis, leucosis, etc), 18-inflammatory processes (tuberculosis, abscess), 35-accessory lobes of mammary glands. It was found that the method in question permitted, taking into account clinical data, in most cases to establish a differential diagnosis between various tumor processes of this localization.
 ...
PMID:[The role of x-ray studies in the diagnosis of soft tissue tumors of the axillary space]. 113 5

Clinical records of 160 patients admitted with fever of unclear origin were reviewed. Of them, all cases with fever of obscure origin (FOO) were selected based on the following criteria: at least two weeks with fever, with an oral temperature of 37.5 degrees C or more during hospitalization and whose clinical history, physical examination, hemocytologic data, erithrosedimentation rate, urinalysis, febrile tests, glutamic-piruvic transaminase, chest and abdomen radiographies were not suggestive of any specific diagnosis. 32 cases of FOO were found, but only the 30 which had been studied previously in another hospital were considered for analysis. Of these 30 patients, 18 were men and 12 women, with a mean age of 36.3 (range 19-64). Infectious diseases caused 40 percent and neoplastic disease 27 percent of cases. The single most frequent cause was non-Hodgkin lymphoma in four cases, followed by tuberculosis and Hodgkin's disease in three patients each. In four cases the cause of fever was not identified. Eleven patients required exploratory laparotomy; in nine of them it was usefull for diagnosis. Our results show a high proportion of neoplastic diseases, probably related with patient's selection and with intrinsic diagnostic difficulty of these kind of diseases.
 ...
PMID:[Fever of unknown origin. A study of cases seen at the third level]. 130 87

Between 1982 and 1988, 174 brains were systematically collected from consecutive, autopsied AIDS patients in a Parisian general hospital without neurology and psychiatry departments. The data obtained under these conditions provide reliable information on the frequency of central nervous system (CNS) involvement in a non-selected population of AIDS patients, most of whom were homosexuals (75.9%). One or several lesions were observed in 148 cases (85%). HIV encephalitis and/or leucoencephalopathy with multinucleated giant cells was found in 33 cases (18.9%). Opportunistic infections were identified in 91 patients (52.3%): toxoplasmosis (65 cases; 37.3%), cytomegalovirus encephalitis (25 cases; 14.3%), cryptococcosis (9 cases; 5.8%), progressive multifocal leukoencephalitis (5 cases; 2.8%), candidosis (1 case) and tuberculosis (1 case). Neoplasias were observed in 23 patients: primary (16 cases; 17.9%) or secondary malignant non Hodgkin's large B-cell lymphoma (3 cas; 1.1%), Kaposi's sarcoma (1 case) and glioma (3 cases; 1.1%). Non-specific lesions (vasculitic, hemorrhagic, metabolic and especially microglial nodules) were common. During the 6 years of study, the rate of CNS involvement was constant. The number of toxoplasmosis cases per year was stable, however, evolutive forms were more prevalent between 1982 and 1986, whereas treated inactive lesions were seen most frequently thereafter. The opportunistic complications were often associated and it should be noted that HIV encephalitis was associated with one of several such infections in 85% of the patients. This high rate of association suggests that these opportunistic infections may play a role in the pathogenesis of HIV encephalitis.
 ...
PMID:[Neuropathology of the brain in 174 patients who died of AIDS in a Paris hospital 1982-1988]. 131 51

In a period of ten years (1980-1989) 6 patients, out of 506 cases of lymphoma, presented an active tuberculosis (1.18%). Five of them had Hodgkin disease in an advanced stage, with predominance of the nodular sclerosis histologic subtype; one had a non Hodgkin lymphoma. Clinical presentation of TBC was mostly focal with a predominance of extra pulmonary involvement (cervical tuberculous lymphadenitis); disseminated disease only appeared in the non Hodgkin lymphoma patient. There was no difference in the severity of the infection when it appeared either before or after multiagent therapy of the hematologic malignancy. There was clinical suspicion of TBC in all of the pulmonary forms of the disease; lymph node tuberculosis, without drainage of caseous material, was a finding related to the routine culture of lymphatic tissue. In biopsy material, in which Mycobacterium tuberculosis was isolated, neither epithelioid cell granulomas with caseation necrosis nor acid-fast bacilli were histopathologically documented. No mortality due to tuberculous infection was registered in this group. TBC prevalence in these lymphoma patients was 1185.7 per 100,000; compared with the prevalence of this disease in the general population (52.3 per 100,000) a significant difference is demonstrated (p < 0.0001) and it is related to Hodgkin lymphoma.
 ...
PMID:[Tuberculosis in patients with lymphomas]. 799 44

A woman aged 31 years had been afflicted with mediastinal lymph node enlargement and hepatopathy for two years. Epithelioid-cell granulomatosis was diagnosed at another institute on the basis of biopsies taken from the liver and thoracic lymph nodes, resulting in the differential diagnosis of sarcoidosis or tuberculosis. Another biopsy was taken from enlarged cervical lymph nodes, after tuberculostatic therapy had remained unsuccessful and had not prevented deterioration of the patient's condition. We diagnosed from that biopsy the syncytial variant of nodular sclerosis of Hodgkin's disease. Immunohistochemically, the tumour cells exhibited positive reactions to antigens CD 15 and CD 30, whereas no evidence was provided to the presence of cytokeratins, lysozyme and S-100 protein. In grading, we associated our case with subtype 2 of nodular sclerosis and clinical stage II. Combined radiotherapy and chemotherapy resulted in complete remission of the tumour disease. Presence of granulomatosis similar to sarcoidosis was confirmed by follow-up examination of the liver and lymph node biopsies which originally had been histopathologically examined at another institute. The question is discussed whether or not this granulomatous reaction reflected an increased immunological defence reaction of the organism to Hodgkin's disease and thus offered an explanation for the unexpected favourable course of the patient's disease.
 ...
PMID:[Syncytial variant of the nodular sclerosing type of Hodgkin's disease in cervical lymph nodes with simultaneous sarcoidosis-like granulomatosis in the intrathoracic lymph nodes and liver]. 142 Jan 10

We conducted a diagnostic biopsy during a period of 8 years (January 1981 - December 1988) on 74 consecutive children (aged under 16 years) who attended the University of Calabar Teaching Hospital, Calabar, for chronic enlarged painless lymphadenopathy, with a view to determining the diseases that commonly present with this symptom in our environment. Histological diagnoses returned were predominantly tuberculosis, neoplasms and nonspecific reactive changes. Each of these conditions was evenly distributed among the entire age group. Neoplasms were mainly Hodgkins and non-Hodgkins lymphoma, with Burkitt's tumour the commonest childhood tumour in Nigeria not contributing significantly to the neoplastic lymphadenopathy. Regional enlargement rather than generalised lymphadenopathy seems to be dominant, the commonest sites of involvement being the cervical followed by the inguinal regions. Chronic lymph node enlargement appears to be rare in our environment and only a few disease conditions manifest with peripheral nodes despite the large number of infections and other inflammatory diseases in Nigerian children.
 ...
PMID:Painless peripheral lymphadenopathy in Nigerian children. 145 35

Bone marrow biopsies from 125 patients at different stages of HIV infection were examined and the histopathological changes are described. Indications for biopsy included peripheral blood abnormalities, search for opportunistic pathogens, a suspected lymphoma or evaluation of its progression. Common histopathological features, suggestive of HIV infection but non-pathognomonic, were: severe hypercellularity (43.2%), myelodysplasia (74.4%), plasmocytosis (86.4%), and lymphocytic (36.8%) and histiocytic infiltrates with or without granulomas (20%). Reticular fibrosis (58.6%), iron deposits (59.2%), vascular congestion and mucoid degeneration of fat (18.4%) were frequently observed. Hypoplasia was usually a late-occurring event and/or may have been iatrogenic. Opportunistic infections were detected in 8 patients: Mycobacterium avium intracellulare (4 cases), Mycobacterium tuberculosis (1 case), Cryptococcus neoformans (1 case), and Leishmania (1 case). Neoplastic complications were found in 3 patients: Burkitt's lymphoma (1 case) and Hodgkin's disease (2 cases). The pathophysiological mechanisms envisaged include the effect of HIV infection on precursor cells in the bone marrow.
 ...
PMID:[The bone marrow in human HIV infection. A bioptic study of 125 cases]. 152 53

Silver staining of nucleolar organizer regions (AgNOR) was used to differentiate malignant lymphoma and chronic lymphadenitis. Aspiration smear samples from lymph nodes of 120 cases, including 43 non-Hodgkin's lymphoma, 3 Hodgkin's disease, 56 chronic lymphadenitis, 7 tuberculosis, 6 reactive hyperplasia and 5 samples from other diseases (epidermoid cyst, branchial cyst, mixed tumor, lymphoepithelioma and nodulous disease), were investigated. The number of AgNORs in 200 cells in each sample was counted, and the mean +/- SD in each disease was calculated: non-Hodgkin's lymphoma, 6.58 +/- 2.37; Hodgkin's disease, 4.22 +/- 0.5; chronic lymphadenitis, 1.16 +/- 0.1; tuberculosis, 1.13 +/- 0.14; reactive hyperplasia, 1.48 +/- 0.25; other diseases, 1.47 +/- 0.31. The results indicate that the AgNOR count in malignant lymphoma differed highly significantly from that in benign disease (P less than .001). The size of AgNORs in malignant lymphoma and chronic lymphadenitis was measured, and the maximum diameter and area of lymphocyte and lymphoma cell were: lymphocyte, 0.93 +/- 0.12 microns, 0.61 +/- 0.13 microns 2; lymphoma cell, 0.83 +/- 0.22 microns, 0.50 +/- 0.25 microns 2. The AgNOR sizes in malignant lymphoma were significantly smaller than in chronic lymphadenitis (P less than .001).
 ...
PMID:Nucleolar organizer regions in aspirates of malignant lymphomas and benign disorders of the lymph nodes. 159 Aug 98


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>