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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Abnormal widening of cortical sulci as seen in posttherapeutic cranial computed tomography (CCT) of 64 children in complete continuous remission (CCR) of acute lymphoblastic leucemia (ALL)/non Hodgkin's lymphoma (NHL) was related to patient data and neurological complications during the application of West Berlin treatment protocol. Age and neurological/neurodevelopmental findings of the patients at diagnosis of their disease positively and significantly correlated with CCT abnormalities. Abnormal pre- and intratherapeutic electroencephalographic (EEG) recordings, the development of a severe polyneuropathy syndrome and/or a considerable loss of weight during treatment were frequently associated with an abnormal widening of cortical sulci. Occurrence of transient early encephalopathy syndrome, development of radiation induced blood brain barrier disturbance and somnolence syndrome were not correlated with these CCT changes. Possible explanations of these abnormalities are discussed.
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PMID:Cranial computed tomography of 64 children in continuous complete remission of leukemia II: relations to patient data and neurological complications. 619 68

The majority of patients with sarcoidosis in this large series have had a number of biochemical investigations performed. Abnormal calcium metabolism was demonstrated in 40% of the patients but permanent renal damage due to nephrocalcinosis as a result of persistent derangement of calcium metabolism was rare. Raised immunoglobulin levels were seen. Half the white and two-thirds of the West Indian patients had elevated IgG levels. Abnormal immunoglobulin levels carried no obvious diagnostic or prognostic significance. Raised alkaline phosphatase levels reflected space-occupying hepatic granulomas and occurred in 23% of patients. Serum angiotensin converting enzyme (SACE) was elevated in half the patients. The highest SACE activity was found in patients with severe parenchymal lung infiltration due to sarcoidosis, and the lowest levels in those with inactive disease or after successful management with steroid drugs. SACE levels were not significantly elevated in four other granulomatous conditions: Crohn's disease, primary biliary cirrhosis, Hodgkin's disease, and active tuberculosis.
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PMID:Biochemical findings in sarcoidosis. 624 57

Malignant lymphomas (ML) differ from other neoplasms by an extreme variety of the morphological terms used for designation of different variants of these tumours and different terms are used to describe the same neoplasm. This resulted in the simultaneous use in different countries of not less than 6 ML classifications including the WHO histocytological classification (1976), which is not universally accepted. Kiel's classification of non-Hodgkin's ML (1974) is the most popular in the majority of the West and East European countries, in USA there is a similar classification by Lukes and Collins (1975). The "Working formulation of ML for the use in clinics" (USA, 1982) starts to be used, although it is simply a terminological compromise also containing certain faults. The historical review of the evolution of the ML concept is given starting from Th. Billroth' works (1883); the concrete examples are given illustrating the dynamics of the ML terms and evaluation of their nature. The singularity of the developmental steps of this concept is noted, in particular the "reticulosis era" (1923-1973). The dependence of ML estimate upon the existing, in a given period, schemes of hemopoiesis is pointed out. The data on the state of this problem in different countries are presented and the necessity of its joint discussion by pathologists and clinicians in order to work out the identical nomenclature for the designation of the same type of ML is outlined.
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PMID:[Current status of the problem of malignant lymphoma (on the centenary of the theory of malignant lymphoma)]. 639 33

A total of 77 cases of Hodgkin's disease have been evaluated and the patients treated at our institution during the past ten years. Advances in diagnostic technology and therapy have improved the outcome of the disease and overall survival. Therapy during this period has not been standardized. Radiation therapy was the primary initial treatment for stages I, II and III, with combined-modality therapy or chemotherapy alone used for more advanced stages. Five-year disease-free and overall survival for stage IA is 81 percent and 95 percent, respectively; 74 percent and 78 percent for stage IIA; 70 percent in both instances for stage IIB; 54 percent and 100 percent for stage IIIA; 75 percent and 100 percent for stage IIIB, and 57 percent and 69 percent for stage IV. Of 13 patients initially treated with chemotherapy, 77 percent have had a complete response. Of the 16 patients (88 percent) having a relapse, 14 have been salvaged with a variety of therapeutic approaches. Overall, five-year survival for 77 patients is 86 percent, with 70 percent having no relapse.
West J Med 1982 May
PMID:Hodgkin's disease in a community oncology center: ten years' experience. 710 5

The pattern of malignant lymphoma (ML) in the Middle East has not been well documented and constitutes a lacuna in the epidemiology of this disease. This preliminary report describes a retrospective study of 46 native Omanis who, at the Sultan Qaboos University Hospital and the Royal Hospital, Sultanate of Oman, were diagnosed in 1990 as having ML. Of the 46 patients with ML, 16 (35%) were found to have Hodgkin's disease (HD) and 30 (65%) had non-Hodgkin's lymphomas (NHL). Among the HD, mixed cellularity (MC) appeared in 9 cases (56%). Among the NHL, 25 (83%) showed a diffuse pattern and 5 (17%) were follicular. Twenty-one (70%) of the NHL were of high-grade type, of which 5 (17%) were Burkitt-like lymphomas. Immunological study of the NHL biopsies revealed 24 (80%) of the B cell type, 2 (7%) of the T-cell type, 1 (3%) of the null cell type and 3 (10%) could not be classified because of scanty material or unsatisfactory fixation. We present in this study the pattern of ML in Oman, which was found to be different from those reported from the West, Far East and Saudi Arabia, with some resemblance to the pattern from tropical Africa.
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PMID:The pattern of malignant lymphoma in Oman. 756 66

One hundred forty-one children were diagnosed with Hodgkin's disease between 1957 and 1986 in the West Midlands Health Authority Region (1991 population, 1.1 million children). Eighty-seven were boys and 54 were girls, representing a significant male:female ratio of 1.5:1 (P < 0.01). The average age-standardized incidence rate was 3.6 per million per year with a significant increase in the older age group (> or = 10 years) in the second half of the period (P = 0.02). The mixed cellularity subtype was more common in those younger than 10 years, with nodular sclerosing disease being seen more in those < or = 10 years. Overall survival at 5 years was 76% (65% at 10 years) with a significant difference (P < 0.001) in survival between the first and last decades. There was six second malignancies, five of which could have been treatment related. A positive history of cancer in close relatives was found in 11 patients, and higher social class was found in more older than younger children. These findings support the hypothesis that Hodgkin's disease may have a viral etiology and may be linked with socioeconomic conditions.
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PMID:Hodgkin's disease in children in the West Midlands, 1957-1986: a large population-based study. 782 44

It is classical to separate gastro-intestinal non Hodgkin lymphomas into two epidemiological profiles: an "occidental" type frequently encountered in West countries (Europe and USA) and an "occidental" type which is dominant in the Middle East regions and is distinguished from the occidental type by the following features: the younger age of patients, the rarity of gastric involvement compared to the small intestinal involvement, the prevalence of Immuno Proliferative Small Intestinal Disease within the small intestinal non Hodgkin lymphomas. An epidemiological study was done on 100 cases of digestive non Hodgkin lymphomas seen in Lebanon between 1965 and 1991 in hospitals affiliated with Saint-Joseph University. The statistical analysis of our study leads to several conclusions: the ISPID is disappearing in Lebanon during the last twenty-five years; the site of gastrointestinal involvement is changing with time, the small intestinal involvement becoming more rare and the gastric involvement more frequent. So during this twenty-five years period, there was an occidentalization of the epidemiological profile. This varying pattern with time in the epidemiology of gastrointestinal non Hodgkin lymphomas could be due to changing in the environmental factors like the intestinal bacterial and parasitological infestation.
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PMID:[Non-Hodgkin's lymphoma of the digestive system. General epidemiology and epidemiological data concerning 100 Lebanese cases seen between 1965 and 1991]. 784 90

Annual incidence of acute leukemia (AL) and non-Hodgkin lymphoma (NHL) per 100,000 residents aged 0-15 years has been compared for 6 South-West regions (supervision territory), 21 control regions (comparison territory) and Bryansk city. Childhood population of the supervision territory, radionuclide contaminated after the Chernobyl accident, was 58,600 residents, that of comparison territory and Bryansk city 158,600 and 98,900, respectively (1992). In 1986-1991 59 ALL cases (annual incidence 3.11 per 100,000), 7 ANLL cases (0.38) 2, 1 and 19 of unspecified leukemia, CML, NHL (1.00), respectively, have been registered. Incidence rate and age distribution for both AL and NHL were typical for childhood population of industrial countries. AL incidence was highest in Bryansk city (4.21), in supervision territory it was 4.1, in comparison regions 3.05. There was a statistically significant excess of AL incidence in 1986 among those aged 0-15 years in the supervision territory based on 8 cases (annual incidence 13, 7, a 95% confidence interval 6-27).
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PMID:[Morbidity from leukemia and non-Hodgkin's lymphoma in the juvenile population of various territories of Briansk district]. 789 28

It is classical to separate gastro-intestinal non Hodgkin Lymphomas into two epidemiological profiles: 1--an "occidental" type frequently encountered in West countries (Europe and USA); 2--an "occidental" type which is dominant in the Middle East regions and is distinguished from the occidental type by the following features: the younger age of patients; the rarity of gastric involvement compared to the small intestinal involvement; the prevalence of Immuno Proliferative Small Intestinal Disease within the small intestinal non Hodgkin lymphomas. An epidemiological study was done on 100 cases of digestive non Hodgkin lymphomas seen in Lebanon between 1965 and 1991 in hospitals affiliated with Saint-Joseph University. The statistical analysis of our study leads to several conclusions: 1--the ISPID is disappearing in Lebanon during the last twenty-five years; 2--the site of gastrointestinal involvement is changing with time, the small intestinal involvement becoming more rare and the gastric involvement more frequent. So during this twenty-five years period, there was an occidentalization of the epidemiological profile. This varying pattern with time in the epidemiology of gastrointestinal non Hodgkin lymphomas could be due to changing in the environmental factors like the intestinal bacterial and parasitological infestation.
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PMID:[Gastrointestinal non-hodgkin's lymphoma: general epidemiology and epidemiologic data based on 100 Lebanese cases seen between 1965 and 1991]. 795 91

In the prospect of a political and economic 'harmonization' of the European Economic Community (EEC) and, possibly, all Europe, the identification of differences in cancer frequencies and trends in major European areas (ie EEC, non-EEC western countries, and eastern European countries) can help to set health priorities. From 1960-64 to 1985-89 all-age mortality rates of some common cancers (mouth or pharynx, pancreas, lung, kidney, prostate and skin) increased substantially especially in East Europe. Conversely, mortality rates from cancer of the stomach, uterus, testis and from Hodgkin's disease declined, but, again, trends in East Europe were less favourable. Some elevations in rare malignancies (non-Hodgkin's lymphomas, multiple myeloma and connective and soft-tissue sarcomas) emerged rather uniformly in Europe, especially in elderly people. Most favourable trends in total cancer mortality were apparent among females in the EEC (minus 7%) and non-EEC western countries (minus 14%). The picture becomes gradually less favourable with respect to non-EEC western European males and eastern European females (virtually no change) and EEC males (plus 13%). With a 25% increase in total cancer mortality rates in the past 30 years, males in East Europe emerge as the 'problem' group. The even wider gap between West and East Europe in cancer rates in young males leaves no hope for future improvements in the absence of effective interventions. Raising public awareness (especially with respect to smoking and alcohol consumption), and increasing motivation and quality controls among health professionals are badly needed in disadvantaged European areas.
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PMID:Comparison of cancer mortality trends in major European areas, 1960-89. 801 82


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