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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Planned laparotomy and splenectomy has been a safe investigation for sixty patients with clinical Stage I, II or III Hodgkin's disease. Twenty-four of the 60 patients (40%) changed stage and 18 patients had their treatment altered as a consequence of the procedure. Forty-three per cent of patients without a palpably enlarged spleen had unsuspected disease when the organ was examined pathologically, although a false positive spleen was uncommon. Eight of 55 patients (14.5%) had intra-abdominal disease which was not detected by lymphangiography. Intra-abdominal disease occurred with all histological sub-types and was found in two patients who had clinical Stage I disease and lymphocyte predominance in their node histology. Sarcoid-like granulomata were found in ten patients, seven in the spleen, one in the liver and spleen, one in the skin and one in the original node biopsy. In the majority of patients, granulomata were associated with nodular sclerosing or mixed cellular histology. In all ten patients the Hodgkin's disease was suppressed by appropriate chemotherapy and disease has not recurred. No patient has shown any clinical evidence of sarcoidosis and the Kveim test done in three patients was negative. Our experience encourages us to recommend staging laparotomy for all adult patients with Hodgkin's disease which does not show obvious generalized spread beyond lymph nodes.
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PMID:An assessment of laparotomy in the management of patients with Hodgkin's disease. 71 70

In this series, the commonest aetiology was tuberculosis (30 cases, 28%), followed by sarcoidosis (18 cases, 17,7%), mediterranean fever (Olmer's disease) (13 cases, 12,1%), brucellosis (8 cases, 7,4%), typhoid fever (7 cases, 6,6%) and idiopathic forms (8 cases, 7,4%). These were followed by Hodgkin's disease, toxoplasmosis, adenosarcoma, and leprosy. Finally, there were single cases due to infectious mononucleosis, B.C.G. reaction, hypogammaglobulinaemia, coeliac disease and temporal arteritis. Half of the patients had hepatomegaly and an increase, in general moderate, in hepatic enzymes (transaminases, alkaline phosphatase). The highest enzyme levels were seen in cases of brucellosis, hepatic enzymes being normal in patients with sarcoidosis.
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PMID:[Granulomatous hepatitis: aetiological study of 107 cases (author's transl)]. 73 1

CFI of whole human serum was measured by a new assay that utilizes chemotactic factor-induced release of a lysosomal enzyme (N-acetyl glucosaminidase) from cytochalasin B-exposed neutrophils as an index of chemotactic activity. The effectiveness of serum as an inactivator of chemotactic factor-induced enzyme release closely correlated with the serum CFI as determined by assay of neutrophil chemotaxis in Boyden chambers. In comparison to serum from healthy persons, there was elevated CFI in the serum from patients with sarcoidosis and Hodgkin's disease by both assay systems. The results indicate that measurement of serum inhibition of chemotactic factor-induced lysosomal enzyme release from neutrophils provides a rapid, reliable, and reproducible assay of serum CFI. (J Lab Clin Med 93:17, 1979.)
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PMID:Biochemical quantitation of the chemotactic factor inactivator activity in human serum. 75 26

The indirect immunofluorescent test in fixed P3HR-1 cells showed the sera from patients with lymphogranulomatosis to contain high titers of humoral antibody to the capsid antigen of Epstein-Barr virus. Higher titers of antibody to EBV were associated with unfavourably running histological variants of lymphogranulomatosis. The lymphoid depletion variant was accompanied by high antibody titers to the virus and had a worse prognosis than the nodular-sclerotic variant with lower antibody titers but better prognosis. The level of antibody in lymphogranulomatosis was stable. No relationship between the antibody level and the stage and results of the therapy given was found. In sera from patients with reticulosarcoma and lymphosarcoma no significant rise of antibody titers to EBV was found as compared with a group of normal donors, while in acute leukosis there was a tend for a decline in antibody titers.
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PMID:[Relation of antibody levels to Epstein-Barr virus to histological variant and clinical course of lymphogranulomatosis]. 76 39

The leukotactic function of patients with sarcoidosis was studied. A defect was found in 19 of the 20 patients tested and was due to moderately elevated serum levels of the chemotactic factor inactivator. The chemotactic factor inactivator levels were not as high as those previously reported in patients with Hodgkin's disease or cirrhosis of the liver. The effect of the inactivator was irreversible and was directed toward all three of the chemotactic factors tested. The physicochemical characteristics of chemotactic factor inactivator in serum from sarcoid patients resembled in most respects the features of chemotactic factor inactivator in normal serum. As expected, the generation of chemotactic activity in some sarcoid serums by zymosan was impaired. The results of this study may relate to some of the reported defects in expression of immunity in sarcoid patients.
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PMID:Leukotactic dystunction in sarcoidosis. 76 31

This is the clinico-pathological report of a case of reticulo-endotheliosis of the nervous system in a 53-year-old white female. She had a history of transient facial palsy followed 6 months later by progressive weakness, paresthesiae and severe pain in both lower limbs. Clinical examination revealed signs of sensory and motor polyradiculoneuritis with involvement of the oculomotor, facial and trigeminal cranial nerves. She died 10 months after the onset because of bronchopneumonia. Pathological findings in the nervous system were limited to the cranial and spinal roots and ganglia. Histopathological examination showed intense infiltration by lymphocytes, histiocytes, plasmocytes and macrophages and a large amount of reticulin. The left oculomotor nerve, both Gasserian ganglia, the right trigeminal nerve and the lumbosacral nerves and ganglia were particularly involved. The previous literature on human peripheral neurolymphomatosis is reviewed and its differential diagnosis from Marek's disease, sarcomas, leukaemic polyradiculoneuritis, sarcoidosis and Hodgkin's disease of the nervous system is discussed. The importance of recognizing this variety of polyradiculoneuritis, and methods of treating it are emphasized.
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PMID:[Human peripheral neurolymphomatosis (reticuloendothelial polyradiculoneuritis)]. 77 23

Cytostatic or hormone therapy for malignant tumors has made some progress during the last few years. Total or, at least, extensive recession of bronchial carcinoma, metastasizing breast tumors and lymphogranulomatosis in Stage IV as the result of chemotherapy or hormone therapy was presented which was substantiated by x-rays.
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PMID:[The efficacy of cytostatic therapy for malignant tumors as determined by x-rays]. 78 82

An electro-physiological compound process to establish the radiolesions in the heart and lung is described. This process contributes to the early exact diagnosis of the permanent and momentary radiolesions. This process would be used by 70 patients with a lymphogranulomatosis and 100 patients with a carcinoma of the mammary glands. Changes in the phases of the systole and the diastole which precede the clinical symptoms, would be observed.
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PMID:[A combined method for lung and heart examination for the diagnosis of early and late radiation lesions following intrathoracic radiotherapy]. 80 46

In a 15-year-old female patient treated with phenytoin (100 mg tds) for symptomatic epilepsy generalised enlargement of lymph nodes, particularly in the cervical region, occurred three weeks after beginning treatment. The histological findings suggested lymphogranulomatosis which could not be confirmed clinically. Despite continuation of phenytoin treatment the lymphoma regressed spontaneously. It appears to have been a rare case of an allergic reaction to phenytoin.
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PMID:[Lymphadenopathy in phenytoin treatment (author's transl)]. 82 5

The extended radiation therapy of lymphogranulomatosis by means of the mantle technique requires individualized focussed satelittes. The production of such individualized, ray divergences considering "lead mantles", however, needs some technical expenditure and causes loss of time. Using Wood's alloy, which has a shielding capacity similar to lead but is well and easily workable because of its low melting point, it is possible to obtain individually adjusted shielding blocks by casting.
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PMID:[Wood's alloy, a material suitable for quick production of individualized shielding blocks in the mantle technique (author's transl)]. 84


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