Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 6 untreated patients the chromosome set of lymphoid cells in the peripheral blood was studied. It was shown that there were quantitative and structural changes of the karyotype arising yet at the early stage of the process. This offers an opportunity to use the cytogenetic test for establishing the differential diagnosis between lymphogranulomatosis and reactive lymphadenitis.
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PMID:[Cytogenetic study of peripheral blood lymphoid cells in children with lymphogranulomatosis]. 42 1

Since 1950 to 1968 in the Nikolaevsk Province Oncological dispensary 1006 breast cancer patients were radically operated upon. 943 patients were followed up, primary multiple tumors being observed in 52 of them (5.5%). Primary multiple tumors in stage I were noted in 2.3% of cases, in stage II--in 7.7%, in stage III--in 4.2%. A second tumor appeared in different terms following the cure of mammary gland cancer: in the other gland--in 28 cases, in the uterus--in 7, in the stomach--in 4, in ovaries--in 1, 7 patients developed skin cancer, 1--cancer of the lower lip and 2--lymphogranulomatosis.
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PMID:[Breast cancer in combination with other malignant tumors]. 43 18

Closed trephine needle biopsy of the bone marrow has become an established procedure in the evaluation of many malignant and benign diseases in adults; however, its role in pediatric pathology has not yet been defined. In the period from February 1974 to April 1978 we have performed 164 such biopsies in 111 children under 15 years of age. A representative specimen has been obtained in over 80% of cases. This series included, in order of frequency, non-Hodgkin lymphomas, Hodgkin lymphomas, aplastic anemias, rhabdomyosarcomas, neuroblastomas, miscellaneous solid tumors, and single cases of histiocytosis X, malignant histiocytosis, sarcoidosis, malignant histiocytoma, and Castleman lymphoma of the hyaline-vascular type. Histology has been found superior to cytology in the detection of neuroblastoma invasion; the evaluation of the true cellularity in aplastic anemia, and the detection of granulomatous tissue in the only case of sarcoidosis. In other diseases histology and cytology gave similar information, except for the few cases of acute leukemia in partial relapse, which has been better defined in the aspirate smears than in the core specimen. Further evaluation of this technique in other patient series appears advisable.
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PMID:Bone marrow biopsy in children: a study of 111 patients. 44 Feb 5

The results of 97 autopsy cases of lymphogranulomatosis showed the causes of death to be either progression of the disease (78 cases), complications of treatment (12) or other diseases (7). The immediate causes of death in the progression of the disease were toxicity (29%), pulmonary insufficiency (22%), pulmonary-cardial insufficiency (12%), hepatic insufficiency (21%), peritonitis (3.4%), sepsis (5.8%), uremia (3.4%), posthemorrhagic anemia (1.7%), cerebral edema (1.7%). The immediate causes of death in complications of therapy were secondary infection (5 cases), posthemorrhagic anemia (3), pulmonary insufficiency (3), cerebral edema (1). In 7 observations death was not due to lymphogranulomatosis: in 2 cases it was caused by disseminated hematogenic tuberculosis, in 2 pneumonia (with cured lymphogranulomatosis, in 1 myocardial infarction, in 1 uremia (aterosclerotic nephrosclerosis) and 1 patient died accidentally.
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PMID:[Causes of death in lymphogranulomatosis]. 45 24

An etiologic study was made of 107 cases of granulomatous hepatitis which were observed in a Department of Internal Medicine between January, 1971 and December, 1977 (excluding the hepatobiliary diseases). The most common etiology was tuberculosis (30 cases, 28 percent) followed by sarcoidosis (19 cases, 17.7 percent), Mediterranean exanthematous fever (13 cases, 12.1 percent), brucellosis (8 cases, 7.4 percent) typhoid fever (7 cases, 6.5 percent) and the idiopathic forms (8 cases, 7.4 percent). A lower rate of incidence was among Hodgkin's disease, toxoplasmosis, adenocarcinomas, leprosy, and those of unknown etiology, classified in this way because the study and follow-up of the patients could not be completed. There were, moreover, individual cases caused by mononucleosis, BCG reaction, hypogammaglobulinemia, celiac disease, and temporal arteritis. From a clinical point of view 50 percent of the patients had hepatomegaly and moderate disturbance of the liver enzymes. The most important enzymatic increases were detected in the cases caused by brucellosis; in the cases which were secondary to sarcoidosis the liver enzymes were normal. A comparison is established between the etiologic incidence of the present series and of others published in the literature. The causes and diagnostic problems of this type of lesion are discussed.
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PMID:[Granulomatous hepatitis. Etiologic study of 107 cases (author's transl)]. 45 94

In experiments on 75 female mice of line SJL/J with lymphograulomatosis, 75 female mice of the same line without lymphogranulomatosis and intact non-lineal mice, the authors have studied the labelled tumorigenic compounds: indium-111, gallium-67-citrates and sodium selenium-75-selenite. It was found that only sodium selenium-75-selenite possesses an enhanced ability to be accumulated in lymphogranulomatosis involved lymph nodes in mice. Whereas indium-111 and gallium-67-citrates contrary to the literature data available showed no enhanced tropism to lymph nodes of mice with lymphogranulomatosis.
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PMID:[Tropism of radiopharmacologic preparations in lymphogramulomatosis in mice]. 46 61

In 71 patients with lymphogranulomatosis (35 males and 36 females aged from 19 to 67 years) the hepatic function was studied prior to and during the cytostatic treatment. There were found considerable disturbances in the liver functioning and parallelism between the activity of the mentioned enzymes and the presence of intoxication, the enlarged liver size and intensity of the pathological process. During the treatment in some patients the activity of the enzymes under study was decreased or normalized. Changes in the activity of blood transminase, aldolase and alkaline phosphatase would reflect the gravity of destructive processes and disturbances in the liver function in patients with lymphogranulomatosis. The data obtained are of certain value for the treatment and prognosis of the disease.
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PMID:[Liver function in lymphogranulomatosis]. 46 63

The features of mitotic regimen of lymphogranuloma were established in examinations of 50 involved lymph nodes in patients with lymphogranulomatosis: increased mitotic activity and the number of pathological mitoses from lymphoid prevalence to lymphoid exhaust. In all the types of metaphase was the predominant stage of mitosis. Significant differences were found in the mitotic regimen and various subtypes of nodular sclerosis.
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PMID:[Mitotic conditions in different variants of lymphogranulomatosis]. 49 92

In vitro production of interferon by blood leukocytes from patients with lymphosarcoma, lymphogranulomatosis, leukemia, cancer tumours, pneumonia, as well as by leukocytes of mice with Rauscher leukemia, and mice in the condition of hyporeactivity to interferon inducer was studied. Alongside with quantitative differences in interferon production, biological differences in the properties of interferons produced of normal and sick humans and animals were revealed. The biological differences consist in that the interferon produced by leukocytes from cancer and leukemia patients interacting with homologous cell culture is conducive to more rapid formation of resistance to the indicator virus than the interferon produced by normal leukocytes. Thus, resistance of the homologous cell culture to the infection with the indicator vesicular stomatitis virus developed within 1--2 hours after contact with leukocyte interferon from patients and only within 5--6 hours after contact with that of normal subjects. This finding is not specific for cancer and leukemia, as the same was observed with specimens from patients with pneumonia and from mice hyporeactive to interferon inducer. It is suggested that patients with cancer and leukemia have a state of interferon hyporeactivity.
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PMID:[Differences in the properties of the interferons produced by the leukocytes of healthy persons and of cancer and leukemia patients]. 50 7

The authors present an analysis of the results of polychemotherapy: MOPP, CCNU+NMU schedule in 36 patients with generalized lymphogranulomatosis of stage IIIB and IVA,B. An experience with the associated chemotherapy has evidenced the effectiveness of this kind of treatment and the possibility to gain the complete remission approximately in 80% of patients.
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PMID:[Results of the combined chemotherapy of stage III and IV lymphogranulomatosis]. 51 66


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