Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

81 patients, 24 with sarcoidosis and the remainder with various other diseases, were tested with three batches of Kveim material prepared from the same spleen. Positive Kveim tests were observed in sarcoidosis, tuberculosis, Hodgkin's disease, ulcerative colitis, rheumatoid arthritis, and Weber-Christian disease. These results show that a positive Kveim reaction to the material under test was not specific to sarcoidosis.
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PMID:Reaction to Kveim test material in sarcoidosis and other diseases. 4 62

A statistical comparison dealing with age, duration of disease and survival period of patients with involvement of the nervous system by malignant lymphomas revealed the following data: 1. With mycosis fungoides, involvement of the nervous system occurs later in life than with lymphogranulomatosis; this difference is statistically highly significant (P less than 0.001). 2. There is no statistical difference (P greater than 0.05) in the duration of either type of malignant lymphoma before the nervous system becomes involved. 3. It is of high statistical significance (P less than 0.001) that, once the nervous system has become involved, the survival period is lower with mycosis fungoides than with lymphogranulomatosis. It can be expected that involvement of the nervous system by mycosis fungoides leads with 79% probability (confidential limits 99% = 47.29--96.22%) to death within 6 months.
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PMID:[Age, duration of disease and survival period of patients with involvement of the nervous system by malignant lymphomas. A statistical comparison of mycosis fungoides with lymphogranulomatosis (author's transl)]. 7 52

Judging from the spontaneous NBT reduction, the indices of phagocytosis and NBT, there is a moderate, but statistically significant diminution of these parameters in leukaemia and malignant lymphoma including plasmocytoma. Moreover, further diminutions could be identified during the acute stage of the disease (first diagnosis or recidive) in acute leukaemia and lymphogranulomatosis, but not for chronic myeloic leukaemia.
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PMID:[Phagocytic granulocyte function in hemoblastoses]. 7 20

In the serum of 27 patients with malignant lymphogranulomatosis the authors determined the serum level of glycoproteid-carbohydrate components (hexose, hexosamine, sialin acid, and seromucoid) and the concentration of 11 different glycoproteids. In the early stage of the disease the immunoglobulin level is moderately increased in the serum, whereas a diminution can be observed in stage IV. The concentrations of ceruloplasmin, alpha-2-macroglobulin and orosomucoid were already increased significantly in stage III. The increase did not continue in stage IV. In the final stage of the disease the concentrations of alpha-1-antitrypsin and haemopexin turned out to be increased considerably. A significant decrease in the transferrin level could be registered in stage III with this diminution also continuing in the further course. Changes of beta-C-globulin and haptoglobin concentrations could not be evaluated statistically. The content of carbohydrate components in the glycoproteids will already increase in the early stage of the disease with this increase continuing in the further course. Among histological types there was a more significant increase of immunoglobulins in those forms rich of lymphocytes.
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PMID:[Immunoglobulins and glycoproteins in lymphogranulomatosis]. 8 Mar 59

Serum angiotensin-converting enzyme (SACE) activity was significantly higher in 90 patients with sarcoidosis (55 +/- [S.D.] 23 nmol min-1 ml-1) than in 80 healthy controls (34 +/- 9 nmol min-1 ml-1). Steroid therapy modified SACE activity; 60 sarcoidosis patients who were not being treated with steroids had significantly higher enzyme activities (58 +/- 24 nmol min-1 ml-1) than 30 steroid-treated sarcoidosis patients (40 +/- 19 nmol min-1 ml-1). In 50% of the non-steroid treated sarcoidosis patients SACE activity was more than 2 S.D. above the mean value for the controls. SACE activity was measured in 22 tuberculous patients (38 +/- 14 nmol min-1 ml-1), 20 leprosy patients (34 +/- 9 nmol min-1 ml-1), 31 with primary biliary cirrhosis (44 +/- 20 nmol min-1 ml-1), 26 with inflammatory bowel disease (31 +/- 9 nmol min-1 ml-1), 8 with hepatic granulomatous disease, 5 with Hodgkin's disease, and 2 with schistosomiasis. The combined false-positive rate for these non-sarcoidosis patients was 10%. Serial SACE assays provide useful information on the course of sarcoidosis and response to steroid treatment.
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PMID:Serum angiotensin-converting enzyme (SACE) in sarcoidosis and other granulomatous disorders. 8 38

A case is reported on the joint presence of chronic lymphatic leukaemia and lymphogranulomatosis in a 58 years old patient. 5 years after diagnosis and therapy of lymphadenosis a lymphogranulomatosis existing in addition to lymphadenosis was discovered by autopsy. Previously a change of symptoms had occurred. This became evident in the regression of palpable lymph node swellings as well as leukocytosis and lymphocytosis, in a change of the differential blood picture and the presence of periodic subfebrile temperatures. Problems connected with these double neoplasias are briefly outlined and discussed.
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PMID:[Coincidence of chronic lymphadenosis and lymphogranulomatosis]. 8 86

In two similar pairs of siblings a histologically confirmed lymphogranulomatosis appeared at an interval of several years in each case. Such observations do not arise through purely coincidental familial frequency but siblings of granulomatosis patients have in fact a much higher risk of contracting Hodgkin's disease than other persons. This gives rise to important considerations for the etiology and pathogenesis of lymphogranulomatosis which are discussed in detail in the light of recent literature.
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PMID:[Lymphogranulomatosis in siblings (author's transl)]. 10 60

Diffusion chambers were used to study the migration activity and blast transformation of lymphocytes in fragments of lymph nodes from untreated patients with lymphogranulomatosis of various histological variants and stages of the disease. Early in the disease, and particularly at its peak, a progressive decrease in the activity of T-lymphocytes was observed indicating the inhibition of cellular immunity in the patients.
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PMID:[Various immunomorphological tests of cellular immunity in lymphogranulomatosis]. 10 7

Under examination were the levels of serum immunoglobulins G, A, M, and D in 25 patients with lymphogranulomatosis and in 22 patients with nonlymphogranulomatous malignant lymphomas. A reliable increase in IgG concentration was found in both groups, but it was more pronounced in cases with malignant lymphomas. The IgA and IgD level also tends to rise but somewhat more sharply in malignant lymphomas. The level of IgM in lymphogranulomatosis patients was not significantly changed, while in nonlymphogranulomatous malignant lymphomas it was raised a little.
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PMID:[Blood serum immunoglobulins in lymphogranulomatosis and other malignant lymphomas]. 11 32

The author presents an analysis of the results of the combination chemotherapy with natulan, vincristin, novembichine and prednisolone in 43 patients showing generalized lymphogranulomatosis, mainly with recurrences following radiation and chemotherapy with different antitumor substances. The results of the combination chemotherapy were compared with the data obtained in management of 94 patients having lymphogranulomatosis, stage III-IV, with natulan solely. It is shown that the combination therapy is effective, in principle, and provides an opportunity to gain objective remission in 65% of cases. A therapeutic effect of polychemotherapy depends on the administered total doses of the substances. A regimen consisting of no less than 5-6 cycles seems to be an optimum one, since it yields the greatest incidence and duration of remissions. As compared with the results of polychemotherapy in the fiven contigency of patients, natulan, used as a single tool of the specific therapy, shows a somewhat better effect.
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PMID:[Combined chemotherapy in generalized lymphogranulomatosis]. 12 9


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