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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 165 patients with tumours of the head and neck were irradiated via fields including the entire cervical portion of the spinal cord. Eight patients (4.8 per cent) developed mild reversible signs of radiation myelitis. Only one of these cases was found among the 44 patients who received a dose to the spinal cord of over 5 000 rad via fields of less than 16 cm in length; 7 cases were patients with Hodgkin's disease who were given up to 3 700 rad via mantle fields. A survey of previous reports on transverse spinal lesions provoked by irradiation revealed a possibility of overdosage in several cases, and dose tolerance limits mentioned previously should accordingly be applied with caution.
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PMID:Neurologic complications after irradiation of the cervical spinal cord for malignant tumour of the head and neck. 81 1

We reviewed the files of 950 patients treated for Hodgkin's disease since 1966 and were able to find five patients treated with radiochemotherapy and irradiated twice on volumes including a cord segment, at various time intervals, and surviving until now. Seven patients with comparable clinical and therapeutic features, but not reirradiated on the cord, were chosen as a control group and were examined with the same diagnostic procedures. The cumulative cord dose in the reirradiated patients was recalculated and ranged from 50 to 70 Gy. All these patients and the control cases were followed up for more than 10 years and presented no or only minor neurological symptoms. We compare the results of both magnetic resonance imaging (MRI) and electrophysiological studies (spinal and scalp recorded somatosensory evoked potentials--SEPs) in an attempt to define the characteristics of the subclinical damage present in these patients. While no cord abnormality was demonstrated with MRI, electrophysiological studies evidenced a clear difference between cases and controls, as far as the D10-P1 conduction time and SEPs average amplitude are concerned. Advantages and drawbacks of a wider use of electrophysiological methods in research work on cord radiation damage are presented, along with the possible implications of the results obtained for the understanding of the pathogenesis and of the dose dependence of radiation myelitis (RM).
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PMID:Neurological damage in patients irradiated twice on the spinal cord: a morphologic and electrophysiological study. 232 Jul 50

Over a one-year period the cerebrospinal fluid (CSF) obtained from a series of homosexual men immunocompromised with either Hodgkin's disease or acquired immune deficiency syndrome (AIDS) was cultured to assess the frequency with which infectious viruses could be recovered. Of 58 patients examined, 4 (6.9%) had CSF cultures that showed a cytopathology consistent with a virus infection. All isolates proved to be herpesviruses. Cytomegalovirus (CMV) and varicella-zoster virus were isolated from CSF obtained from 2 patients with neurological features consistent with a subacute encephalitis common among AIDS patients. CMV was also recovered from the CSF of an AIDS patient who developed an ascending myelitis of herpesvirus origin. Finally, a CSF sample obtained from an immunodeficient homosexual man who showed no detectable neurological abnormalities consistently yielded herpes simplex virus type 1 in culture. These results suggest that seeding of the CSF with infectious virus is an uncommon event in this patient population. However, our experience should not dissuade attempts to culture viruses from CSF in similar cases. Successful isolations may prove beneficial in the diagnosis of an accompanying neurological illness and facilitate treatment with antiviral therapy when indicated.
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PMID:Recovery of herpesviruses from cerebrospinal fluid of immunodeficient homosexual men. 300 Feb 85

A 47-year-old woman presented with the chief complaint of gait disturbance and pain of bilateral lower limbs. She was diagnosed as having necrotizing myelitis because myelography was normal and incidentally bilateral adrenal tumor was recognized by ultrasonography and computed tomography. Left adrenalectomy was performed under the diagnosis of bilateral non-functioning adrenal tumor or metastasis to the adrenal glands with unknown origin. The tumor was 10 x 6 x 3 cm in size and 175 g in weight. The pathological diagnosis was non-Hodgkin lymphoma (diffuse large cell type). After combination chemotherapy of vincristine, cyclophosphamide, prednisolone and adriamycin, residual right adrenal mass showed a remarkable reduction, but unfortunately she died 5 months later postoperatively because of complications of lung edema and pneumonitis.
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PMID:[A case of bilateral adrenal non-Hodgkin lymphoma]. 337 94

The infections due to herpes-varicella viruses occurring in 191 patients with Hodgkin's disease form the basis of this report. There were overall 41 episodes (26.7%) in 40 patients, distributed as follows: varicella in three cases, atypical herpes-varicella in two cases, and herpes zoster in 36 cases, the latter showing systemic spread in seven instances, one to the central nervous system (myelitis) and six to the skin. The mortality was 2.5% of all infections, and 33% of the varicella cases. Morbidity was apparent as postherpetic neuralgia in seven patients (19.4%), postherpetic paraplegia in one case (2.5%), and severe thrombocytopenia in another case (2.5%). The statistical study of the factors contributing to the development of reactivation episodes demonstrated that neither age, sex, or previous splenectomy were influential. The results obtained in relation to the stage and histologic type of Hodgkin's disease can not be fully evaluated because of the artifact introduced by other variables such as type of therapy and observation time. There was a clear relationship with the aggressiveness of therapy, because 81.7% of the viral episodes occurred in patients submitted to total radiotherapy with or without chemotherapy, or with partial radiotherapy plus chemotherapy. In the patients with systemic spread there was a clear relationship with prior splenectomy (p less than 0.005). The clinical features of these patients are commented upon.
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PMID:[Infections due to herpes-varicella viruses in Hodgkin's disease (author's transl)]. 626 37

Eighty-three patients with Hodgkin's disease were treated with a combination of chemotherapy and radiotherapy. 43 were included in protocol 1 (from january 1970 to january 1974) and 40 in protocol 2 (february 1974 to december 1977). In protocol 1, staging laparotomy was not systematically performed (20 cases). Treatment consisted of 2 intravenous injections in Vinblastine and total nodal irradiation. In protocol 2, laparotomy was systematic in patients over 50 (35 cases). Patients with stages 1 and II treated as mentioned above. Patients with stage III received two Mopp courses followed by total nodal irradiation. Patients older than 50 with stages I and II and poor prognosis factors received chemotherapy only. Laparotomy was associated with a 0% mortality rate and a 3,6% morbidity rate. No myelitis or pericarditis were observed. Herpes zoster occurred in 24% of the patients, pulmonary apex fibrosis in 6%, hypothyroiditis in 2,4%, and leucopenia in 3,6%. Two late infectious complications were fatal. No solid tumor was apparent. Acute leukemia and non-Hodgkin malignant lymphoma developed in two patients. Good tolerance, shortness of treatment, and remission rate, warrant the pursuit of protocol 2 in which systematic laparotomy for patients under 50 allows total nodal irradiation and therefore reduction of chemotherapy.
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PMID:[Non-gonadic complications of chemoradiotherapy in Hodgkin's disease. A study of eighty-three patients (author's transl)]. 628 Feb 86

From January 1965 to December 1975, 122 patients diagnosed with Hodgkin's disease, Stage I-A, II-A, and III-A were treated at the Department of Radiation Therapy at Hahnemann Medical College and Hospital. Twenty-five patients with Stage I-A, 54 patients with Stage II-A, and 43 patients with Stage III-A were accepted for treatment. Retrospective analysis was made to define the impact of the cell type, clinical and pathologic stage, and tumor bulk on prognosis. Of the 25 patients with Stage I-A Hodgkin's disease, 13 were clinically staged and 12 pathologically staged. Nine patients received extended-field radiation therapy with the overall relapse-free survival of 100% at 5 and 9 years; 16 patients received mantle radiation only, with overall survival of 84% and relapse-free survival of 68% at 5 and 10 years. Of 54 patients with Stage II-A Hodgkin's disease (32 clinically staged and 22 pathologically staged), six patients received involved field radiation therapy with overall survival of 68 and 49% at 5 and 10 years, and relapse-free survival of 33 and 17% at 5 and 10 years. Nineteen patients received limited-field radiation therapy (mantle or inverted Y) with overall survival of 49% at 5 and 10 years, and relapse-free survival of 42 and 31% at 5 and 10 years, and 29 patients received extended-field radiation therapy (mantle and para-aortic or TNI) with overall survival of 88% at 5 and 10 years, and relapse-free survival of 82 and 73% at 5 and 10 years. The overall and relapse-free survival at 5 and 10 years in 22 patients pathologically staged II-A (treated by different techniques) are 95 and 75%. Forty-three patients with Stage III-A Hodgkin's disease (treated with different techniques) reveal an overall survival of 79 and 64% at 5 and 10 years, and relapse-free survival of 58 and 45% at 5 and 10 years. Complications consisted of six patients with overt symptoms of hypothyroidism, two patients with peripheral neuropathy, one patient with radiation myelitis, and two patients with symptoms of leukoencephalopathy. Two patients developed second malignancies.
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PMID:Hodgkin's disease. Results from a program in radiation therapy. 642 36

The Authors present a series of 7 cases of late myelitis consequent on radiotherapy in patients treated for Hodgkin's lymphoma. These 7 cases represent 1.4% of the 500 cases of Hodgkin's lymphoma subjected to radiotherapy at the Istituto Nazionale Tumori of Milan from 1970 to 1980, and all concern the dorsal tract of the spinal cord. They were found at an interval varying from 5 to 13 months after radiotherapy. The 7 cases were treated with equivalent doses varying from 951 to 1077 rets. The possibility is discussed to further reduce the incidence of these lesions from radiotherapy to less than 1%, administering equivalent doses lower than 1015 rets, without increasing the risk of recurrences of the disease.
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PMID:[Delayed myelitis caused by radiation in patients treated for Hodgkin's disease]. 651 15

An unusual case of primary angiitis of the central nervous system associated with Hodgkin's disease in a 55-year-old-man is reported. After a 10-month history of acute transverse myelitis, the patient was diagnosed as having nodular sclerosing-type Hodgkin's disease involving the retroperitoneal lymph nodes. The patient died of a brainstem hemorrhage 1 week after a 15-day course of chemotherapy. Primary angiitis was documented on autopsy examination. To our knowledge, only nine similar cases have been reported in the literature, and none of them was associated with a sole initial spinal cord presentation. Owing to the rarity of this disease entity, a high index of suspicion and awareness of the association between primary angiitis and Hodgkin's disease are essential for early diagnosis.
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PMID:Primary angiitis of the central nervous system associated with Hodgkin's disease. 865 60

Infections of the central nervous system by Herpes simplex viruses (Herpes simplex type 1 and Herpes simplex type 2) are uncommon in acquired immune deficiency syndrome and are often clinically and pathologically atypical. We have collected 11 cases of herpes simplex encephalomyelitis in AIDS patients reported in the literature. Only 3 of these cases presented with a typical, necrotizing, limbic encephalitis. Other clinicopathological patterns included ventriculitis, rhombencephalitis and myelitis. Ventriculitis and rhombencephalitis were usually due to infection by HSV-1, whereas myelitis was mostly due to HSV-2 infection. Distinction between the 2 types of virus is often difficult by immunohistochemistry due to frequent cross reactivity and usually requires tissue culture, in situ hybridization, or polymerase chain reaction. Association of HSV encephalomyelitis with productive infection of the central nervous system by the human immunodeficiency virus was only found in one case. In contrast, co-infection with cytomegalovirus was found in 9 of the 11 cases. One case also had had varicella zoster virus vasculitis, and another case also had a cerebral malignant non Hodgkin's lymphoma in which Epstein Barr virus genome was identified. This supports the view that concomitant herpes-virus infections of the central nervous system is a characteristic feature of AIDS.
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PMID:[Central nervous system infection due to Herpes simplex virus in AIDS]. 938 7


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