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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bivalent influenza vaccine (containing antigens A/Victoria and A/New Jersey) was administered to 52 patients with hematologic malignancies, and pre- and postvaccination antibody titers to both antigens were determined by hemagglutination-inhibition. In comparison to healthy controls, mean antibody titer elevations were lower for both antigens in all disease groups, being significant (p less than 0.05) for A/Victoria in patients with non-Hodgkin's lymphoma, acute leukemia and lymphoproliferative diseases, and for A/New Jersey in patients with Hodgkin's and non-Hodgkin's lymphomas. In comparison to controls, significant depression of antibody response to both antigens was seen in patients on combination chemotherapy (p less than 0.0005), to a lesser extent in patients on daily single alkylating agent chemotherapy (p less than 0.05), while untreated patients did not differ significantly. Lymphopenia and depressed immunoglobulin levels were associated with a higher failure rate in eliciting "protective" greater than or equal to fourfold antibody titer increases. The findings suggest that patients with hematologic malignancies who are receiving chemotherapy at the time of vaccination are unlikely to attain seroconversion to protective antibody levels with influenza vaccine.
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PMID:The influence of chemotherapy on response of patients with hematologic malignancies to influenza vaccine. 76 Nov 65

To justify the performance of an invasive technique as an aid to determining diagnosis and therapy in any condition, one must correlate the benefits derived with the adverse effects of performing that procedure. The review of the records of the patient indicates that clinical staging remains a moderately inaccurate means of assessing the extent of the disease in patients with Hodgkin's and non-Hodgkin's lymphoma. Lymphangiogram remains an aid to the surgeon in the localization of suspicious nodes. It is of greater accuracy in the patient with Hodgkin's lymphoma as compared with those with non-Hodgkin's lymphoma. Conversely, laparotomy for staging was not of as great a value in the patients in the non-Hodgkin's group as in those in the Hodgkin's group, and the incidence of complications was higher in the non-Hodgkin's group; especially in the patients with advanced disease. Laparotomy for staging is of significant benefit in the Hodgkin's lymphoma group, and the complication rate is not prohibitive. Laparotomy for staging in the non-Hodgkin's lymphoma group, on the other hand, is of less value than it is in the Hodgkin's group and is associated with a substantially higher complication rate in the face of advanced disease. In non-Hodgkin's lymphoma, individual decisions regarding laparotomy must be used, and the routine use of laparotomy may not be warranted.
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PMID:Laparotomy for staging of Hodgkin's and non-hodgkin's lymphoma. 83 60

Non-Hodgkin lymphoma is a heterogenous group of lymphoreticular malignancies that can be classified into six major cell types. In comparison with Hodgkin disease, non-Hodgkin lymphoma is more common and tends to occur in older persons. The investigative procedures for clinical and pathologic staging are similar to those used in Hodgkin disease, except that staging laparotomy is performed less frequently. Results of biopsy reflect a high incidence of bone marrow, liver, and splenic hilar and mesenteric lymph node involvement in Non-Hodgkin lymphoma than in Hodgkin disease.
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PMID:Basic concepts in non-hodgkin lymphoma. 84 Aug 3

Main sources of information on the epidemiology of malignant tumors are the statistical data on mortality and incidence and the studies on the distribution of frequencies. The mortality from non-Hodgkin's lymphomas ranges between 0.1 and 6 cases per 100 000 per year. Statistics upon incidence are based on cancer registers of the general population. The figures of incidence range between 1 and 10 cases per 100 000 per year ("Cancer Incidence in Five Continents"). Men are affected with non-Hodgkin's lymphoma twice as frequently as women. Burkitt's lymphoma and the lymphoma of small intestine are particularly interesting, showing a peculiar geographical and age distribution.
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PMID:[Epidemiology of non-Hodgkin's lymphoma]. 85 44

Fifty-eight patients with a variety of haematological lymphoproliferative or myeloproliferative disorders were given bivalent subunit influenza virus vaccine, and their antibody responses after vaccination were compared with those of a normal control group. Although geometric mean titres of the patient group showed lower initial antibody levels, smaller increments, and lower final titres, after vaccination 83% of this group achieved satisfactory antibody levels to the A/Pt Chalmers strain, and 57% to the B/Hong Kong strain. The lowest antibody levels and smallest responses occurred in patients with non-Hodgkin's lymphoma, Hodgkin's disease, and multiple myeloma. Four of seven patients who showed low antibody levels, and no response to the first injection, responded to a second dose.
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PMID:Immunization with influenza vaccine in patients with haematological malignant disease. 85 89

The value of 75Se-selenite scintigraphy in clinical staging was investigated in 45 patients with Hodgkin's disease and in 28 patients with non-Hodgkin's lymphoma. Of these, 9 patients had recurrence of previously treated lymphomas. The scintigraphic results were compared with clinical, cytologic, histologic and radiographic findings in different anatomic regions. 75Se-selenite scintigraphy resulted in 6 to 20 per cent false negative findings, 15 to 43 per cent false positive and 12 to 20 per cent equivocal evaluations, the accuracy being least in the abdominal region. The relatively high rediation dose delivered by 75Se-selenite, furthermore, makes it less attractive for use in the primary diagnosis of malignant lymphomas.
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PMID:75Se-Selenite scrintigraphy in the clinical staging of malignant lymphomas. 86 76

To evaluate the usefulness of percutaneous needle liver biopsy in the initial staging of lymphoma patients, 115 patients presenting to M. D. Anderson Hospital between Sept 1, 1972, and Aug 31, 1975, and having either percutaneous (45) or celiotomy (70) liver biopsy were identified. Sixty-six patients had Hodgkin's disease, 49 non-Hodgkin's lymphoma. Overall, results of 13 biopsies were positive--six by percutaneous biopsy, seven by celiotomy. Results showed little difference in yield between percutaneous and celiotomy biopsy. Positivity increased with increasing clinical stage, increasing age (Hodgkin's patients), and increasing number of abnormal liver function tests. It is concluded that percutaneous liver biopsy is useful in lymphoma staging, especially in patients with at least one abnormal liver function test, and in patients with Hodgkin's disease, mixed cell type. The early identification of otherwise unrecognized stage IV disease can spare many patients the morbidity of staging celiotomy.
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PMID:The efficacy of percutaneous liver biopsy in the initial staging of patients with lymphoma. 87 18

Seventy-one patients with lymphoma underwent staging laparotomy. Fifty of the patients had Hodgkin's disease and the remainder, non-Hodgkin's lymphoma. One patient died from pulmonary embolism on the tenth postoperative day, one required temporary assisted ventilation, one required reoperation for hemorrhage and six patients had infectious complications which responded to appropriate antibiotic therapy. Despite extensive noninvasive procedures, including bone marrow trephine biopsy and lymphangiography, in approximately 30% of the patients, the disease was restaged as a result of the operation. Since primary management of these diseases is critically dependent upon accurate staging, we conclude that, at the present time, this procedure is indispensible for proper management, as it contributes information not available from other currently used investigational techniques.
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PMID:The value of laparotomy in staging of lymphoma. 87 35

Three hundred and thirty-six B-mode ultrasound examinations of the retroperitoneal region were performed on 179 patients with Hodgkin's disease or non-Hodgkin's lymphoma; histological confirmation was available in 56 patients. Ultrasonography was correct in predicting retroperitoneal periaortic lymph node involvement in 87.5% of cases. Node size was correctly predicted 98.2% of the time, and nodes 2 cm or larger in diameter were detectable. Ultrasound was more accurate than physical examination, and as accurate as gallium-67 imaging and lymphography in disease detection. The combination of ultrasound and gallium imaging gave the best accuracy of detection (97%).
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PMID:The accuracy of retroperitoneal ultrasonography in Hodgkin's disease and non-Hodgkin's lymphoma. 91 62

The records of 360 patients with malignant lymphoma treated with various forms of combination chemotherapy from 1966 to 1974 were reviewed. A total of 181 infections was found in 125 patients. The most frequent types of infection were pneumonia (31%), skin infections (17%), urinary tract infections (13%) and septicemia (11%). An etiologic organism was was identified in 133 infections (73%). The most common causative organisms were bacteria (77%), especially gram-negative bacilli. Viral infections accounted for 18% of the infections with 21 of the 24 being due to herpes zoster. These were more frequently found in patients with Hodgkin's disease (14/21) than in the other lymphomas. Among patients with Hodgkin's disease, 53% treated with COP developed infections compared to only 27% treated with MOPP (p = 0.039). Among patients with non-Hodgkin's lymphoma, infections were more frequent in patients treated with Adriamycin containing combinations than with COP. Neutropenia (i.e. less than 1,000 neutrophils/mm3) was associated with 35% of infections in this study and was seen more often in patients with non-Hodgkin's lymphoma (p = 0.048).
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PMID:Infections in patients with malignant lymphoma treated with combination chemotherapy. 91 45


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