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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifty-one lymphograms were performed in children; the indications, technique and results are discussed. Indications are the search for retroperitoneal involvement in lymphogranulomatosis, lympho-sarcoma and reticulum cell sarcoma; in the search for metastases from malignant tumours, particularly abdominal neuroblastoma, soft tissue sarcomas of the abdomen and lower extremities, testicular tumours and malignant melanomas and finally, for primary lymph-oedema and lymphangiomas. Technique is the same as for adults, but requires particular manual dexterity. Children under six years require general anaesthesia. Amongst 28 children with malignant lymphomas, pathological changes in the retroperitoneal lymph nodes were found in seven. In six, this resulted in a change of the staging. Five out of 16 lymphograms in children with malignant tumours showed evidence of lymph node metastases. All six lymphangiograms in children with lymphoedema and lymphangiomas were abnormal.
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PMID:[Lymphography in childhood (author's transl)]. 12 77

A study was made of the potentialities of lymphography using a new radiopaque medium chromethiotrast (a solution of harmless fat-soluble anthraquinone dyes fixed with ethiotrast). The agent is intended for combined x-ray and visual investigation of the lymphatic system. Lymphograms of 76 patients (with Hodgkin's disease, prostatic cancer, cancer of the female organs, breast, bladder, rectal cancer, and secondary limb lymphedema) were analyzed. Chromethiotrast is easily administered in the lymphatic bed ensuring a good contrast density of the lymphatic vessels permitting the detection of their structure. Chromethiotrast is quickly discharged from the lymphatic system, causing no marked side-effects provided all precautions necessary for the administration of iodobutyric radiopaque media, are taken.
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PMID:[Potentialities of lymphography using chromethiotrast, a new x-ray contrast medium]. 145 58

Magnetic resonance imaging (MRI) demonstrates surface anatomy, nerves, and soft tissue pathology. Selective placement of the cursor lines in MRI displays specific anatomy. The MR images can then be used as adjunct in teaching surface anatomy to medical students and to other health professionals. Because the normal surface anatomy could be imaged at UCLA's radiology department, it was decided to image soft tissue abnormalities with MR to assist in patient care. Patients imaged were scheduled for special procedures of the chest or staging lymphangiograms. Patients were placed into categories depending on known diagnosis or interesting clinical presentation. The diagnostic categories included Hodgkin's disease, melanoma, carcinomas (eg, lung or breast), lymphedema, sarcomas, dermatological disorders, and neurological disorders. All images were orchestrated by the radiologist. This article discusses both the teaching and clinical impact on patient care.
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PMID:Magnetic resonance imaging of chest wall lesions. 192 May 9

This paper reviews current knowledge and hypotheses about the physiology of lymph production and lymph flow and the aetiology and classification of lymphoedema. One of the earlier contributions in the 1930's by Allen suggested that primary lymphoedema was caused by congenital underdevelopment of lymph vessels. At that time he described two clinical varieties (congenital and praecox) but later suggested a further subdivision into inflammatory and non-inflammatory types of lymphoedema. Kinmonth in 1957 produced the first clinical classification dividing all cases into primary or secondary lymphoedema but at that time gave no indication as to the cause of the primary variety. In the 1950's Kinmonth also developed a radiological classification which has contributed considerably to our knowledge of the anatomical abnormalities of the lymphatic system in primary lymphoedema. However, despite the widespread use of Kinmonth's classification the lymphographic appearances in primary lymphoedema give little or no clue to the aetiology of the disease process. The aetiology of primary lymphoedema is not known. There are various descriptive classifications based on age of onset and radiological findings for instance, but none attempts to explain the pathophysiology of the disease. We have therefore described our current knowledge of the known physiology and the potential abnormalities of the collection and passage of lymph from the interstitial space to the blood system. Based on this we have presented a simple classification of the aetiology of lymphoedema. Thus primary lymphoedema may be defined as lymphoedema caused by a primary abnormality or disease of the lymph conducting elements of the lymph vessels or lymph nodes. Secondary lymphoedema is oedema caused by disease in the nodes or vessels that began elsewhere (e.g., neoplasia or filariasis), or lymphocytic proliferative disorders such as Hodgkin's disease or following surgical extirpation of lymph nodes or vessels. There are three groups of primary lymphoedema in which the functional abnormality and its cause are known; namely (a) large vessel abnormalities such as congenital aplasia of the thoracic duct or cysterna chyli, (b) congenital lymphatic valvular incompetence or congenital aplasia and (c) lymph node fibrosis. The remainder are characterised by a reduced number of lymphatics on lymphography. Such patients can be described as having obliterated lymphatics. If they present within a few years of birth they were probably born with too few lymphatics. However, those who present later in life may have acquired obliterative disease, the cause of which is still obscure.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Lymphoedema: pathophysiology and classification. 388 29

Two cases of Hodgkin's disease are described, initially manifested with unilateral lymphedema of the lower extremity. The appearance of pronounced lymphedema of a lower extremity, as the first clinical manifestation and presenting sign of Hodgkin's disease is extremely rare. The surgical treatment of this condition consisted in removal of the involved lymph nodes of the inguinofemoral area and at the same time in omental transposition of a lymphatic communication of the afflicted area with the peritoneal cavity. The procedure was successful in ameliorating the lymphedema. No episodes of postoperative cellulitis occurred and good functional capacity of the extremity was achieved.
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PMID:Lymphedema as the first manifestation of Hodgkin's disease. 728 73

Anaplastic large-cell cutaneous lymphomas (ALCL) represent a heterogeneous group. Primitive cutaneous lymphomas are exceptional, sometimes with a deceptive clinical aspect, but must be considered as a distinct clinicopathologic entity. We report a case of a cutaneous ALCL, appearing 7 years after a homolateral Hodgkin ganglionic lymphoma and occurring on a chronic lymphoedema of the arm. A Stewart-Treves angiosarcoma was suggested owing to its location, vascular aspect and low histologic differentiation. Immunohistochemistry was helpful in making the diagnosis of ALCL. Southern blotting analysis revealed a rearrangement of the beta-chain of the T-receptor gene, thus suggesting the T-cell origin of this lymphoma.
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PMID:Ki-1-positive large-cell cutaneous lymphoma mimicking a Stewart-Treves angiosarcoma. 789 4

Angiosarcoma is a rare and highly malignant neoplasm. Cutaneous angiosarcoma not associated with postmastectomy lymphedema is rare. There are only eight reported cases of development of cutaneous angiosarcoma in a lymphedematous extremity in a patient with preexisting malignancy other than breast cancer. This is the first reported case of development of cutaneous angiosarcoma in a lymphedematous extremity in a Hodgkin's disease survivor. A review of cutaneous angiosarcoma associated with lymphedema and a discussion of the pathogenesis of angiosarcoma are included.
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PMID:Cutaneous angiosarcoma as a second malignancy in a lymphedematous leg in a Hodgkin's disease survivor. 796 37

Angiosarcoma has frequently been described arising within chronic lymphoedema of the upper limb following mastectomy and radiotherapy for carcinoma of the breast. We report a case of angiosarcoma arising in a lymphoedematous leg that had been subjected to radiotherapy 20 years previously for Hodgkin's disease. The diagnosis was expedited once the patient noticed the development of bleeding nodules. Prognosis of angiosarcoma is poor with treatment options being wide-excision surgery, palliative radiotherapy or chemotherapy. Unusual bruised areas or bleeding nodules developing within chronic lymphoedematous limbs should be biopsied to exclude the diagnosis.
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PMID:Chronic lymphoedema and angiosarcoma. 1045 27

Angiosarcomas are rare tumors in children, usually occurring in soft tissue and liver. By contrast, angiosarcoma in adults usually occurs in the extremities in conjunction with lymphedema. Mesenteric angiosarcoma has only rarely been reported. When angiosarcomas arise in this location, they usually represent a 2nd malignancy following Hodgkin's lymphoma. We report a child who presented to the emergency room with an acute abdomen and underwent emergency surgery for a mesenteric angiosarcoma with associated lymphangiectasia of the bowel and mesentery. A brief review of the literature and the nomenclature of these unusual tumors are discussed.
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PMID:Primary mesenteric angiosarcoma in a child with associated lymphangiectasia: a case report. 1914 55

A 33-year-old man presented with lymphoedema and obstructive nephropathy and was first diagnosed as retroperitoneal fibrosis (RF) with consistent clinical picture and radiographic findings. Further CT-guided biopsy was performed and non-Hodgkin lymphoma was diagnosed based on pathological results. RF is usually diagnosed through clinical presentation and imaging studies. However, our case proved that biopsy should be considered to exclude malignancy, even with typical presentations of RF. Follow-up after six courses of R-CHOP (rituximab, cyclophosphamide, vindesine, epirubicin and prednisone) regimen revealed complete resolution of symptoms.
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PMID:Non-Hodgkin lymphoma mimics retroperitoneal fibrosis. 2392 90


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