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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From a histologic review of cases coded as Hodgkin's disease and reticulum cell sarcoma, 12 cases were selected as examples of stem cell lymphoma in which the preponderant cell has characteristics of the B immunoblast. Clinically, these lesions affect the elderly (average age 57.3 years), disseminate early, and, with a few exceptions, progress rapidly to a fatal termination. Morphologically, the neoplastic stem cells, which have pyroninophilic cytoplasm, form diffuse infiltrates with an admixture of acidophilic cells. As a regional variation, the pattern in these lesions overlaps histologically with that seen in angioimmunoblastic lymphadenopathy. The overlap in patterns is presumptive evidence that the angioimmunoblastic pattern at times may be a precursory expression of the stem cell lymphoma. On the basis of morphologic features, these tumors are interpreted as a variant of B cell lymphomas.
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PMID:Stem cell (immunoblastic) lymphoma. A variant of B lymphocytic lymphoma. 6 79

The present paper reports on a 38-year-old patient with left supraclavicular adenopathy, clinically suspect of tuberculosis. Histologic examination showed disappearance of the lymph node structure due to diffuse, nodular hyperplasia of epithelioid and Sternberg-Reed cells. The particularities of this rare form of Hodgkin's disease, described by Lennert, are discussed, as well as problems of differential diagnosis.
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PMID:Hodgkin's disease with predominant epitheloid cells. 14 Mar 8

The application of biochemical studies for the detection of Epstein-Barr virus (EBV)-DNA in human tumor cells is discussed. These studies resulted in the consistent demonstration of viral nucleic acid in African Burkitt's lymphoma biopsies and in epithelial tumor cells of nasopharyngeal carcinomas. The viral DNA resides within those cells regularly in multiple copies per cell. Besides these tumors our group detected significant concentrations of EBV-DNA in a German lymphoma patient revealing histological characteristics of Burkitt's lymphoma. Moreover, virus DNA was also found in a patient suffering from immunoblastic lymphadenopathy. More than 50 additional B-cell lymphomas and more than 40 biopsies from patients with Hodgkin's disease did not contain detectable amounts of EBV-DNA when tested by nucleic acid hybridization. A tentative scheme of EBV-induced pathogenesis is discussed.
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PMID:Biochemical approaches to detection of Epstein-Barr virus in human tumors. 17 25

Five renal transplant recipients exhibited giant systemic lymphadenopathy shortly after transplantation. Biopsy specimens did not show Hodgkin's lymphoma. Immunosuppression was continued in all patients. In contrast to the rapidly fatal course of malignant lymphoma in transplant recipients, adenopathy in these five patients has uniformly resolved. Patients have been observed for 6 to 15 months with no evidence of residual disease. Interval biopsy specimens are not malignant. Each patient received antithymocyte globulin from a single lot for 10 to 21 days after transplantation. During administration, T cell lymphocytes were suppressed to 5% of control values. When lymphadenopathy occurred, T cell values rebounded to 371% of control values. Toxoplasmosis titers as well as viral cultures of lymph node biopsy specimens were negative. These data indicate a benign course of this histologically malignant disease and suggest a lymphoblastic rebound phenomenon to antithymocyte globulin.
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PMID:Pseudolymphoma in renal allograft recipients. 20 91

T lymphocytes, forming sheep erythrocyte rosettes at 37 degrees C, have been described in thymus glands, mitogen and allogeneic cell stimulated lymphocyte cultures, and acute T cell lymphoblastic leukaemia. This paper describes the finding of such lymphocytes in lymph nodes of a variety of disorders including Hodgkin's disease, Lennert's lymphoma, malignant lymphoma of large transformed T lymphocytes, immunoblastic lymphadenopathy, metastatic carcinoma, and other disorders. A large number of tonsils, but not reactive lymph nodes, also contained a significant number of those T lymphocytes. The significance of these findings in relation to interpretation of immune red cell rosettes and to the subclasses of T lymphocytes is discussed.
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PMID:37 degrees CE rosettes in various malignant and non-malignant disorders. 29 39

The clinical course of a 33-year-old man with generalized lymphadenopathy bearing all physical, laboratory and histologic characteristics of "angio-immunoblastic lymphadenopathy with dysproteinemia" (AILD) is described. Therapy was without significant benefit and the patient died 22 months after initial diagnosis. At autopsy in addition to the characteristic cellular polymorphism of AILD, numerous Hodgkin's cells and Sternberg-Reed cells were identified in the lymph nodes and spleen. Pleomorphic cellular infiltrates containing an increased number of immunoblasts and some giant cells were found also in the portal spaces of the liver. The evolution of Hodgkin's disease (H.D.) from AILD suggests that the latter may have represented a reaction to the agent which causes H.D..
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PMID:Angio-immunoblastic lymphadenopathy terminating as Hodgkin's disease. 30 Jun 50

A 56-year-old man with chronic lymphocytic leukemia who developed Richter's syndrome is described. The criteria for diagnosis are given and the histology is discussed. We agree that Richter's syndrome represents a peculiar complication of chronic lymphocytic leukemia and not a separate disease entity. As such, Richter's syndrome must be known and recognized by those evaluating patients with lymphadenopathy whose basic diagnosis may be confused with Hodgkin's disease or "histiocytic" lymphoma.
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PMID:Richter's syndrome. 33 29

Viable cell suspensions were prepared from 31 nodes diagnosed non-Hodgkin's malignant lymphoma, and from 30 non-malignant nodes. The cells were examined and counted by phase contrast microscopy. The suspensions were characterized by the percentage of large cells and by a colchicine-sensitivity index. The finding of more than 6% large cells or the finding of a sensitivity index of more than 30% was considered a positive test for a malignant lymphoma. According to these criteria there were 2 false positives in 30 reactive nodes and one false negative in 31 malignant nodes. Findings on 3 nodes diagnosed angioimmunoblastic lymphadenopathy suggested malignancy. The colchicinesensitivity index of blood lymphocytes seemed useful for monitoring lymphoma patients for leukemic involvement.
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PMID:Cytology and colchicine sensitivity of viable cells from lymph nodes with malignant lymphoma. 34 97

A study of 81 childhood lymphomas diagnosed in the Department of Pathology of Pahlavi University Medical Center, Shiraz, Iran, encompassing all histologically diagnosed childhood lymphomas from the Fars Province, Southern Iran over a 14-year period (1963--1976) revealed a 3:1 male predominance and a 1:4 frequency compared to adult lymphomas. Peripheral lymphadenopathy at the initial physical examination was almost twice as common as deep node involvement. Comparison of cumulative and age-standardized (to world population) incidence rates with those of selected Tumor Registries in various continents revealed a higher rate in our region of both non-Hodgkin's and Hodgkin's lymphoma relative to some of the Western countries. Our incidence rates were in general intermediate between Western populations on one hand and some South America, African and Asian populations on the other. Hodgkin's disease accounted for 64% (males) and 88% (females) of lymphomas and mixed cellularity was the commonest histologic subtype. Histologically almost all non-Hodgkin's lymphomas were diffuse at the time of diagnosis.
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PMID:Childhood lymphoma in southern Iran. 37 62

A patient with chronic idiopathic myelofibrosis was subjected to splenectomy 1 year after diagnosis. As a clinically unexpected finding, lymph node biopsy suggested the presence of non-Hodgkin lymphoma. The patient was subjected to intensive combined cytostatic therapy. In the following months, signs and symptoms of myelofibrosis regressed remarkably. The patient died 31 months after splenectomy in massive gastrointestinal bleeding. At post-mortem, myelofibrosis could not be detected in three bone marrow areas and a regular, fat-containing, hypercellular marrow was present. The nature of the previous lymph noede pathology was reconsidered, and angioimmunoblastic lymphadenopathy was diagnosed.
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PMID:Chronic idiopathic myelofibrosis. A reversible disease?. 40 78


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