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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. In Hodgkin's disease patient's immunological in vitro and in vivo parameters are of prognostic importance. 2. Skin test reactivity correlates to peripheral T-lymphocyte counts and Con A induced lymphoblastogenesis. 3. Con A is the most sensitive in vitro indicator for detecting latent immunodeficiency. 4. Hodgkin patients in long term remission after tumor reductive therapy exhibit a qualitative and quantitative lymphocyte defect. 5. In Hodgkin patients Herpes virus related antibody titers are elevated against Epstein Barr virus (EBV). The elevation coincides with a decreased T-cell number and function. Antibodies against other Herpes viruses (HSV, CMV, VZV) are in the normal range, when tested by the complement fixation method.
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PMID:[Immunologic status in Hodgkin patients: correlation with Epstein-Barr virus titers]. 17 35

Antibody titers to Epstein-Barr virus (EBV)-related antigens, i.e. viral capsid antigen (VCA), the D and R components of the early antigen (EA) complex and the EBV-associated nuclear antigen (EBNA), were determined in a series of 86 patients with non-Hodgkin lymphomas and in 150 matched control subjects. The lymphoma patients belonged to four histological groups: diffuse, nodular, hyperbasophilic malignant lymphoma (HML) and unclassified. The EBV-related serological data were compared to the incidence of antibodies to other herpes viruses, i.e. cytomegalovirus (CMV), herpes simplex virus (HSV) and varicella zoster virus (VZV), and correlated with immune disorders, which are particularly frequent in the HML type of lymphoma. The results revealed a significantly higher incidence of anti-EA-D titers in lymphoma patients and slight but significant increases in the geometric mean anti-VCA titers in the HML and unclassified group of patients. These elevated anti-EBV titers in patients were not associated with an increase in titres of antibodies to other herpes viruses. They did not correlate with the signs of immune deficiency observed or with the incidence of auto-antibodies.
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PMID:Anti-EBV antibody titers in non-Hodgkin lymphomas. 18 35

One hundred and ten skin infections with herpes virus were seen in a uniform group of 1,002 lymphoma-leukaemias dominated by non-Hodgkin's lymphoma (385) and Hodgkin's Disease (327). They appeared with a significantly increased frequency in the course of Hodgkin's Disease, and between the ages of 60 and 69 for the other groups. In the Hodgkin's cases they appeared characteristically during complete remission and in the others during the active phase of their disease. Only exceptionally was there evidence of contact infection. Also these infections seemed mainly due to the re-awakening of a latent virus infection as against a failure of natural defense mechanisms of the organism, which the disease itself and the therapeutic regime might alter in a variable fashion.
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PMID:[Cutaneous herpesvirus infections and malignant blood disorders. Epidemiology]. 18 72

During the period of three years ((1972-1974), serum samples from 60 patients (children and adolescents) with lympho-hematopoietic system diseases were examined for antibodies to all four human herpesviruses. Among these were 26 active Hodgkin's disease (AHD) patients and 6 HD patients with a minimum five years' remission. Simultaneously matched controls (age, sex) of AHD patients were examined. Antibody levels against the viral capsid antigen of Epstein-Barr virus (EBV/VCA) in AHD patients were significantly higher, with overrepresentation of higher titres (greater than or equal to 1:160), than in matched controls. The lowest EBV/VCA antibody titres were in the leukemia-non-Hodgkin's lymphoma patients. We could not prove any significant relationship between cytomegalovirus or herpes simplex virus type 1 antibody titres and AHD or any other disease of lympho-hematopoietic system. The varicella-zoster virus antibody titres in AHD patients were significantly higher than in matched controls. No significant differences in antibodies against EBV/VCA and the other human herpes viruses between the evolution and remission period of AHD patients could be detected. No differences in EBV/VCA antibody titres were observed between the healthy school-children aged 10 to 15 years who were and who were not in contact with a HD patient.
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PMID:Herpesvirus group antibodies in children with Hodgkin's disease. 19 63

The suspension lymphoblastoid cell line named ChSL-1 was established from the tumor node of a patient with Hodgkin's disease. The cells of this culture produce a virus with morphological and physicochemical properties of herpes viruses. Immunologic study of the isolated virus demonstrated great similarity with the Epstein-Barr virus (EBV).
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PMID:Isolation of Epstein-Barr virus from cultured cells of a patient with Hodgkin's disease. 20 Apr 51

Since the first description by Apitz paraproteins were for a long time regarded as biologically abnormal proteins which normally do not appear in the human plasma. According to the modern biochemical knowledge this determination of the notion can no more be acknowledged, since analyses of amino acids did not reveal any differences in the composition of the complete paraproteins and the immune globulins. Apart from the complete paraproteins which consist either of gamma, my, delta, alpha or epsilon heavy chains on the one hand and of kappa or lambda easy chains on the other hand, also molecule fragments and isolated heavy or easy chains, respectively, appear. Like immune proteins paraproteins are formed by B-lymphocytes and their transformation forms, respectively, in which case the monoclonality represents their specific characteristic. Thus exist close relations to malignant changes of the B-lymphocyte system, in particular to the non-Hodgkin-lymphomas. Several functional peculiarities of the paraproteins, such as autoantibody effect, lymphocytotoxicity, aggregation ability and binding affinity to blood cells lead to multiform clinical phenomena. To this belong immune defects, nephropathies, haemocytopenias, amyloidoses and haemorrhagic diatheses. As evoking cause of the alteration of B-lymphocyte system with activation of one or several cell clones (e.g. in double paraproteinaemia) tumour viruses are taken into consideration. After an infection with oncogenic herpes viruses irreversible cell transformations in the lymphatic system have been proved. Thus it is doubtful, whether there are indeed true benign paraproteinaemias. One has rather to speak only of relatively benign forms of the course.
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PMID:[Immunology and oncology of paraproteins]. 22 94

The tumours associated to lymphoid leucosis and Marek's disease are compared with lymphoproliferative diseases of man and other species, by morphological, immunomorphological, and aetiological criteria. Morphological and immunomorphological similarities were found to exist between lymphoid leucosis and malignant lymphomas of the B-cell system in man, more particularly, follicular lymphoma, lamphoblastic lymphosarcoma of the B-cell type, Burkitt's lymphoma, and immunoblastic lymphoma. Equivalent similarities with Marek's disease are relating particularly to Hodgkin's disease, infectious mononucleosis, and malignant lymphomas of the T-cell system. Aetiological relations were found to exist between lymphoid leucosis and the oncorna-virus-dependent lymphatic tumours in mammals, while similarities with Marek's disease were relating to infectious mononucleosis, Burkitt's lymphoma, and herpes-virus-dependent lymphatic tumours in monkey. Reference is made to the model nature of both lymphoid leucosis and Marek's disease and the resulting relevance to tumour research.
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PMID:[Comparative pathology and etiology of lymphatic tumors in fowl]. 69 29

The authors report a new case of the association Hodgkin's disease and Kaposi's sarcoma. A woman of North African origin and suffering from mediastinal Hodgkin's disease developed, after the commencement of polychemotherapy with radiotherapy, Kaposi's cutaneous sarcoma, typical, clinically, histologically and by electron microscopy. In the light of this new case, the authors review 41 cases of the Hodgkin-Kaposi association found in the literature and discuss the inter-relations between Kaposi's sarcoma and diseases of the haemoreticular system, in particular carcinomas, immuno-depressive states (notably in association with renal transplants) and virus disorders (essentially herpes). It might be possible to incriminate in the aetiology of Kaposi's disease a carcinogenetic process of viral origin during a state of immuno-depression.
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PMID:[Association of Kaposi's sarcoma and Hodgkin's disease]. 101 98

In a series of 33 cynomolgus monkeys (Macaca fascicularis) experimentally infected with Simian Immunodeficiency virus (SIV), strain smm3, 13 animals developed malignant Non-Hodgkin lymphomas. These lymphomas presented with unusual primary manifestations like in the orbita, testes, and brain. The morphological features and immunophenotyping identified the tumors as high malignant B-cell lymphomas. In all tumors as well as in tumor-derived cell lines a cynomolgus B-lymphotropic herpes virus (CBLV) with structural homogeneity to the Epstein-Barr virus (EBV) could be demonstrated by Southern blotting with EBV-specific probes. The lymphoma cells also expressed CBLV-associated nuclear antigens involved in B-cell transformation crossreacting with EBNA-specific human sera and monoclonal antibodies. Ig-gene rearrangement studies revealed clonal populations, however, no translocations of the c-myc oncogene could be detected. The lymphomas developing with high frequency in SIV-induced immunodeficiency resemble a major subtype of human EBV-associated AIDS lymphomas. This animal model can therefore be used to further elucidate interactions of HIV and EBV in AIDS-related lymphomagenesis.
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PMID:[Opportunistic malignant lymphomas in SIV infected primates--a model for Epstein-Barr virus associated lymphomas in AIDS]. 128 56

Serial serum samples from 37 patients with Hodgkin's disease (HD) and 39 healthy controls were studied for antibodies to human herpes virus-6 (HHV-6) using ELISA and indirect immunofluorescent antibody (IFA) tests and to the Epstein-Barr virus (EBV) using a radio-complement fixation assay. Antibodies to HHV-6 in the pre-treatment sera from the HD patients were not significantly different from those of controls, but significant changes in titers related to clinical course were noted among the HD patients. HHV-6 IFA titers increased significantly in the course of follow-up in patients who relapsed and decreased significantly over time in patients who did not. These serologic studies support tissue-based investigations indicating that EBV plays a greater etiologic role in HD than HHV-6, although HHV-6 serology may be of prognostic value or may assist in identifying individuals with immunologic abnormalities. The identification of diverse HHV-6 antibody patterns using different assays may reflect the presence of a number of antibodies with varying implications, similar to those identified for EBV.
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PMID:Antibodies to human herpes virus-6 and clinical course in patients with Hodgkin's disease. 131 31


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