Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The long term alterations of T and B lymphocytes in the peripheral blood of patients treated with regional irradiation for various malignancies were examined. Eighty patients were tested at various intervals after the completion of irradiation. Absolute lymphocyte counts, the percentages of T cells and B cells, and the blastogenic response to phocyte reaction (MLR) were determined. Nearly all patients initially had absolute lymphocytopenia and one-third of the patients tested 3 years after completion of irradiation had lymphocyte counts which were more than two standard deviations below the normal range. The depression was not specific for either the T-or B-lymphocyte subpopulations. The PHA response was impaired for extended periods of time after the completion or irradiation. Differences in the mean response of lymphocytes to PHA were noted for all concentrations of the mitogen, but were most marked with suboptimal concentrations of PHA. The MLR was below the lower limits of normal in 70% of the recently irradiated patients. There was a gradual recovery of the ability to respond in the MLR, and all patients tested more than 4.5 years after the completion of therapy had a normal response. These results were compared with those obtained in patients treated with total lymphoid irradiation for Hodgkin's disease. Although three appeared to be a difference in the effect of radiation on lymphocyte subpopulations in the two groups, the effects on lymphocyte function were similar.
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PMID:The long term effects of radiation of T and B lymphocytes in the peripheral blood after regional irradiation. 14 54

Chlorozotocin was given to 37 patients with advanced malignant tumors in a daily X 5 schedule at 6-week intervals. Total iv doses for each course ranged from 75 to 200 mg/m2. Myelosuppression was dose-limiting, with a platelet count depression regularly observed at doses of greater or equal to 150 mg/m2; leukopenia occurred only at the highest dose level. Nausea and vomiting were mild and uncommon. No hyperglycemia or adverse drug-related effects on renal or hepatic function were observed. No major antitumor activity occurred; however, three patients with renal cell carcinoma and one patient each with lung cancer, ovarian carcinoma, and Hodgkin's disease had minor objective decreases in tumor size. A dose range of 150--200 mg/m2 iv for each 5-day course is recommended for phase II studies.
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PMID:Phase I trial of chlorozotocin. 15 63

Sera from unselected and untreated patients with Hodgkin's disease (HD) were examined for antibodies to Epstein-Barr viral (EBV) capsid antigens (VCA). Delayed cutaneous hypersensitivity reactions were carried out with purified tuberculoprotein (PPD). Highly purified blood lymphocytes of the same patients were studied morphologically and classified for cell surface markers. Incorporation of 14C-thymidine was used as a measure of spontaneous DNA synthesis and DNA synthesis after exposure to different concentrations of three mitogens (PHA, Conconavalin A and pokeweed mitogen) and PPD. The distribution of EBV titres was in good agreement with previous reports. Most patients were lymphopenic, due to subnormal levels of T lymphocytes. The lymphocyte stimulation and skin tests showed different degrees of impairment in a considerable number of the patients. The results in 43 patients indicated that a relation exists between the immune defect and the anti-VCA titres. High serological anti-VCA reactivity was related to a poor cutaneous response to PPD, a decreased level of T lymphocytes in the blood and a depression of mitogen-induced DNA synthesis.
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PMID:Epstein-Barr virus (EBV)-associated antibody patterns in relation to the deficiency of cell-mediated immunity in patients with Hodgkin's disease. 19 67

The reactivity of peripheral blood lymphocytes from patients with advanced malignancy was assessed by mitogen-induced stimulation of protein synthesis as measured by 3H-leucine incorporation. It was confirmed that the lymphocyte response of patients was depressed. Furthermore, the lymphocytes of 15 out of 27 cancer patients, selected because of their low responses, inhibited the reactivity of normal lymphocytes in co-cultures. The lymphocytes from one patient with Hodgkin's disease were also inhibitory. In contrast, lymphocytes from healthy subjects, patients with chronic lymphocytic leukaemia, lymphosarcoma or multiple myeloma caused no suppression. Experiments with purified cell populations from patients with carcinoma indicated that purified T cells responded to mitogens while unseparated lymphocytes failed to respond and that the inhibitory activity was due to adherent cells, presumably monocytes. There was no evidence for B-cell-mediated suppression. However, in two cases inhibition was caused by isolated T cells of the patients and not by adherent cells. These experiments suggested that one mechanism for the depression of cell-mediated immunity seen in patients with advanced cancer may be the nonspecific suppresssion of certain T-cell functions by circulating monocytes.
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PMID:Depressed in vitro peripheral blood lymphocyte response to mitogens in cancer patients: the role of suppressor cells. 30 Nov 22

A study has been made of twenty-five untreated patients with Hodgkin's disease (H. D.), ageing from 3 to 13. We have analyzed the correlations of T and B lymphocytes of peripheral blood and the involved lymph nodes and also the functional peculiarities of T-cells in PHA-response. It is shown that as well as adults children with H. D. have the depression of T-system of immunity, more marked in the presence of general symptoms and biological stage "b". No significant influence of the clinical stage on the level of immunological disorders has been found.
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PMID:Hodgkin's disease in children: investigation of T and B lymphocytes. 30 45

Simultaneous measurements of leucocyte numbers and function have been made during combination chemotherapy for advanced Hodgkin's disease. There was a marked fall in the numbers of circulating mononuclear cells during the chemotherapy cycle in many patients. The migratory, phagocytic, candidacidal, and bactericidal activities of polymorphs and monocytes were frequently depressed. Patients often showed isolated abnormalities while clinically free from infection. In contrast, simultaneous depression of several parameters appeared to be associated with infection.
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PMID:Assessment of host defence against infection during chemotherapy of Hodgkin's disease. 31 66

Hodgkin's disease is characterized by unique features setting it apart from other malignancies. Clinically, systemic symptoms are often prominent and spontaneous remissions may be seen. As major immunological aberrations, a reactive humoral response with hypergammaglobulinemia and a depression of cell-mediated immunity are observed. Pathologically, the diagnosis is based on the presence of pleomorphic morphology; this consists of an infiltrate of reactive inflammatory cells sometimes forming granulomatous lesions with or without varying numbers of the cells presumed to be malignant. The nature of these malignant cells remains undefined, with data supporting mainly B-cell, but also macrophage origin. Clear-cut evidence for monoclonality is available only in prognostically unfavourable histological forms.
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PMID:Pathophysiological aspects of Hodgkin's disease. 31 76

Thirty-three patients with non-Hodgkin lymphoma have been treated with total body irradiation (TBI). A very high remission rate is obtained in lymphocytic lymphomas (83%), but response in histiocytic lymphoma is extremely poor. Bone marrow study suggests that marrow depression following TBI is transient and complete recovery occurs provided the bone marrow is not already compromised by previous chemotherapy and radiation therapy. Extreme caution is required when TBI is repeated as this may lead to progressive marrow hypoplasia.
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PMID:Total body irradiation as a primary therapy in non-Hodgkin lymphoma. 37 10

56 patients with Hodgkin's disease treated with large field megavolt irradiation are presented. Complications in the parenchymal organs were few, although patients developed an appreciable grade of pulmonary radiofibrosis, two patients had a myocardial infarction and one patient thrombosis of the portal veins. Depression of the bone marrow frequently interfered with the radiation treatment. In five cases radiotherapy had to be discontinued. In three cases bone marrow depression persisted to the time of death. The total mode treatment was often to be discontinued and the treatment with cytostatics was started. The extended and total node treatment for Hodgkin's disease must be planned to spare as much of the bone marrow as possible.
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PMID:Complications after megavoltage therapy of Hodgkin's disease. 40 31

The case represented above reminds the description of Freud concerning the special relationship in obsessive neurosis to the theme of death, i.e. that these patients find a constant preoccupation in reflecting over the duration of life as well as of the possibility of death of those who are in close relationship to them. Furthermore, the world in which our patient lives, has the quality of threatening and rejecting ("Drohung und Abstossung") described by von Gebsattel in his study on the phenomenology of the obsessional.--The young special-school teacher who was 24 years old in the beginning of the therapy, suffered not only from depression, but from obsessions in thinking certain thoughts, and compulsions, mainly controls. The facts in his fate: early death of the mother, sickness of the father, a congenital abnormity of one eye which demanded several operations, and, last not least, school-years passed in a college of Benedictine monchs, created the roots of his neurosis. And when, in the age of 20 years, he fell in love with a girl, he had to discover that she was suffering from Hodgkin disease, which put him in the dilemma whether to stay with her or to seperate. In this situation he asked for therapeutic help which proceedings were reflected in a rich material of dreams.
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PMID:[Participating therapy of a compulsive neurosis. The history of a monastery student]. 41 14


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