Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 51 year old man developed chylothorax from a non-Hodgkin lymphoma located in the abdomen. The main causes of chylothorax are trauma and malignant disease. The condition is quite often idiopathic. The treatment is usually a combination of surgical treatment, conservative treatment, high voltage radiation and/or pleurodesis with a sclerosing agent.
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PMID:[Chylothorax]. 223 55

6 years after mantle field irradiation for stage IA Hodgkin's disease, a patient presented with right-sided chylothorax. Even after thorough investigation no etiology for the chylothorax was found. It is suggested that chylothorax can be due to previous radiotherapy.
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PMID:Chylothorax after mantle field irradiation for Hodgkin's disease. 405 75

We discuss the efficacy and limitations of CT and MRI in the assessment of the pleura and pleural cavity. With CT and MRI findings from 610 patients, we address six topics: 1) Normal anatomy of the pleural cavity, 2) Pleural effusion, 3) Pleural tumors, 4) Pyothorax, 5) Lung cancer, and 6) The pleura as a mirror of systemic diseases. CT showed specific findings of acute bleeding. MRI was sensitive enough for the diagnosis of subacute bleeding and chylothorax. In the evaluation of pleural tumors, CT and MRI revealed specific evidence of pedunculated localized fibrous tumors and lipomas. In long-standing pyothorax, it is important to detect any associated secondary malignancies. CT and MRI show as a mass penetrating the bony thorax. B-cell non-Hodgkin malignant lymphoma is the most commonly associated malignancy. The sensitivities for diagnosis of pleural extension of bronchogenic carcinoma are 80% with CT and 86% with MRI. The specificities are 89% with CT and 75% with MRI. To study the pleura as a mirror of systemic diseases, we used high resolution CT to examine 104 patients without evidence of the diseases mentioned above. Eighteen of those 104 patients were found to have pleural thickening, and all 18 were smokers. Of the 24 non-smokers, none had pleural thickening. The difference in the occurrence of pleural thickening between smokers and non-smokers was significant (p < 0.01).
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PMID:[Radiological approach to the pleura and pleural cavity with CT and MRI]. 760 23

Chylothorax is a rare complication of both Hodgkin's and non-Hodgkin's lymphoma (NHL). We describe a patient with a diagnosis of low grade NHL who had a persistent chylothorax unresponsive to chemotherapy, who had been diagnosed with low grade NHL. The condition rapidly resolved following mediastinal radiotherapy and did not recur despite the subsequent relapse of the NHL.
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PMID:Chylothorax in non-Hodgkin's lymphoma managed by mediastinal radiotherapy. 859 Jul 6

Intrathoracic involvement is common in both Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). The most common manifestation is mediastinal lymphadenopathy. In HD, nodal involvement is by contiguity and usually involves the superior mediastinum, while the findings in NHL are more variable. Pulmonary parenchymal disease occurs in 38% of HD and 24% of NHL. In untreated HD, parenchymal involvement is invariably associated with mediastinal lymphadenopathy and often with widespread disease. Three distinct radiological patterns of pulmonary lymphoma are recognised: nodular, bronchovascular-lymphangitic and pneumonic-alveolar. Rarely lymphoma may be endobronchial. Pleural effusion occurs in 16% of lymphoma patients and is usually associated with disease elsewhere. It is frequently caused by lymphatic obstruction but may be due to direct pleural involvement by tumour. Chylothorax may occur in NHL but is unusual in HD. Diagnosis of intrathoracic lymphoma is by transbronchial or transthoracic biopsy or by needle aspiration of tissue or pleural fluid. The addition of immunostaining improves the diagnostic yield in equivocal cases. Treatment and prognosis vary depending on cell-type, location and extent of disease.
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PMID:Pulmonary involvement in lymphoma. 862 61

A patient with a remote history of Hodgkin's lymphoma was seen with recurring bilateral pleural effusions, finally diagnosed as chylothorax after many thoracenteses. The patient also had a previous history consistent with chylous ascites. The only plausible etiology of the chylous effusions (and ascites) was previous radiation therapy to the chest and abdomen. This cause of nontraumatic chylothorax is unusual and has been described infrequently in the medical literature.
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PMID:Chylothorax: the result of previous radiation therapy? 910 28

A 22 year-old man complaining of slight thoracic pain, was found to have a right pleural effusion in his chest X-ray. The pleural aspiration yielded chylous fluid and radiological examination and biopsy of a mediastinal mass led to the diagnosis of Hodgkin's disease of the nodular sclerosis type with supra- and radiologically infradiaphragmatic disease and a pathological fracture of the sternum. After complete initial aspiration of the pleural effusion the chylothorax did not recur following initiation of a combination chemotherapy, and a clear regression of the lymphoma was found after the first 3 cycles. This case provides an example of an oligosymptomatic, right sided chylothorax as the first manifestation of Hodgkin's disease in a young immuno-competent patient.
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PMID:[Chylothorax as the initial manifestation of malignant Hodgkin lymphoma]. 963 26

Chylothorax is an uncommon condition rarely seen outside the clinical scenario of trauma or malignancy, and management may be difficult. We report the case of a 52-year-old man with a right chylothorax occurring 23 years after mantle irradiation for Hodgkin's disease. In addition, a Medline literature search was performed. Chylothorax occurring post-irradiation is rare and the aetiology is uncertain. Recurrent malignancy must be excluded. There are a number of management options and our patient was successfully treated with a combination of thoracocentesis, medium chain triglyceride diet and thoracoscopy with talc pleurodesis. There was no evidence of recurrent chylothorax at 2 years follow up. Prompt assessment and treatment is required. Surgical measures need to be considered early if medical treatment is unsuccessful.
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PMID:Chylothorax occurring 23 years post-irradiation: literature review and management strategies. 1102 96

Since chylothorax is uncommon and has multiple causes, its best treatment choice is not clear. Recent reports show that octreotide is useful in the treatment of chylothorax secondary to cancer or caused by surgical procedures. We report a 21 years old male with a chylothorax secondary to a non Hodgkin lymphoma. Treatment with octreotide changed the color and triglyceride content of pleural effusion. Serum albumin and proteins increased and the effusion subsided after the second cycle of chemotherapy with CHOP. Thus octreotide was discontinued on the 27th day of therapy and pleural drainages were withdrawn. He was discharged in good conditions, 38 days after admission.
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PMID:[Octreotide for bilateral chylothorax secondary to lymphoma. Report of one case]. 1644 75

Iatrogenic chylothorax is an uncommon thoracic duct injury, but well-known and serious complication after thoracic surgeries. Recently, video-assisted thoracoscopic surgery has been applied in the management of postoperative chylothorax and could be indicated earlier. We report herein a case of postoperative chylothorax managed successfully by early thoracoscopic direct suture repair of the site of chylous leak that developed after the thoracoscopic resection of mediastinal mass and surrounding fat with ectopic thymus in a patient with persistent myasthenia gravis with non-Hodgkin lymphoma.
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PMID:Thoracoscopic direct suture repair of thoracic duct injury after thoracoscopic mediastinal surgery. 1731 61


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