Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 34-year-old patient had radiotherapy and chemotherapy for Hodgkin's disease of the nodular sclerosing type 2 A thirteen years prior to the treatment of a right cancer of the breast in the stage M0 N1 T3. Seven months later the patient had a left cancer of the breast in the stage M0 N0 T4. The literature is reviewed and the possibility of occurrance of secondary carcinoma following treatment of Hodgkin's disease is discussed.
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PMID:[Bilateral carcinoma of the breast after radiotherapy and chemotherapy for Hodgkin's disease (author's transl)]. 71 Aug 84

In a 22-year-old male, who had been irradiated 16 years previously for Hodgkin's disease, a radiation-induced thyroid carcinoma developed. This was the only case with such development in a group of 207 cases with Hodgkin's disease who were treated by irradiation including the thyroid gland.
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PMID:Thyroid carcinoma induced by irradiation for Hodgkin's disease. Report of a case. 72 46

Ferritins are a group of isometric proteins having an important function in iron storage and metabolism and are found in high concentration in the liver, spleen and bone marrow. Acidic isoferritins are found in human fetal liver, primary mammary, gastric and pancreatic carcinomas, and are termed carcinofetal ferritins. Elevated levels of serum ferritin were found in patients with various malignant diseases such as Hodgkin's disease, chronic myeloblastic, granulocytic and lymphatic leukemias and myeloblastosis, in patients with breast cancer, multiple myeloma, malignant lymphoma, carcinoma of the gastro intestinal tract and germinal cell tumors of the testis. Recently a subpopulation of circulating T lymphocytes bearing surface ferritin was found in patients with breast cancer and untreated Hodgkin's disease. No such lymphocytes were demonstrated in normals or in patients with benign breast disease. The appearance of such subpopulation in the circulation is an early manifestation of the neoplastic disease, and its identification may provide a tool of potential diagnostic and prognostic importance in the management of Hodgkin's disease and breast cancer.
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PMID:The significance of ferritin in malignant diseases. 73 72

Lymphocytes isolated from the peripheral blood and tumour tissues of patients with African Burkitt's lymphoma (BL) showed a reduced cap-forming ability and increased agglutinability by concanavalin A (con A) compared to normal lymphocytes. Lymphocytes from the blood of patients with chronic lymphocytic leukaemia, Hodgkin's disease and other malignant lymphomas showed a similar reduction in cap formation and increase in agglutination compared to normal lymphocytes, lymphocytes from patients with carcinoma, and lymphocytes from patients with non-malignant disorders. The cap formation of lymphocytes from a healthy donor or a lymphoma patient was independent of the source from which the cells were isolated, e.g., lymph-node, spleen or blood. Lymphoma cell lines established from tumours of BL patients and lymphoblastoid cell lines originating from other sources also exhibited an increased agglutination and reduced cap formation with con A. Further studies indicated that EBV-carrying human lymphoid lines had a reduced cap-forming ability compared to EBV-negative lines.
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PMID:Concanavalin A receptors on the surface membrane of lymphocytes from patients with Burkitt's lymphoma, other malignant lymphomas, leukaemia and lymphoma cell lines. 75 2

A few years ago Everson and I assembled all the examples of spontaneous regression in the world medical literature from 1900 to 1960 and added numerous cases from expriences of our friends. Our figure was 176. We excluded squamous cell carcinoma of the skin, leukemia, Hodgkin's disease, and a large number of cases that did not fulfill the prerequisites of confirmed diagnosis and no significant treatment. The four most common examples of regression were carcinoma of the kidney (31), neuroblastoma (29), malignant melanoma (19), and choriocarcinoma (19); these constituted more than half the group. We did not require that the regression be permanent because it appeared that the explanation of temporary regression would be just as important as the cause of permanent regression. There was no proven specific cause of the regression, but the following mechanisms had a possible relationship: immunologic action, elimination of carcinogens, trauma (altering the antigen-antibody relationship), hormones, irradiation, infection and/or fever, and drugs or chemicals. The most applicable of these is elimination of the carcinogen. Immunologic reactions seem to offer the best explanation, and the potential of humoral immunity is more impressive than that of cellular immunity.
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PMID:Spontaneous regression of cancer and the importance of finding its cause. 79 60

An electro-physiological compound process to establish the radiolesions in the heart and lung is described. This process contributes to the early exact diagnosis of the permanent and momentary radiolesions. This process would be used by 70 patients with a lymphogranulomatosis and 100 patients with a carcinoma of the mammary glands. Changes in the phases of the systole and the diastole which precede the clinical symptoms, would be observed.
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PMID:[A combined method for lung and heart examination for the diagnosis of early and late radiation lesions following intrathoracic radiotherapy]. 80 46

The dilution in the circulating blood of lymphocytes lablled in vitro with 3H-cytidine was examined after autotransfusion in 9 patients with Hodgkin's disease (HD) stage II A-IV B, 5 of whom were untreated; in 2 untreated patients with carcinoma, and in 1 treated patient with scleroderma. The blood transit time of exchangeable lymphocytes was 37 +/- 18 min in the patients with HD and 26 +/- 6 min in the other patients. The proportion of exchangeable (recirculating) small blood lymphocytes was 39-84% in HD and 81-91% in the carcinoma patients. The relation between the size of the circulating pool of small blood lymphocytes and the total exchangeable (recirculating) lymphocyte pool was 1:20 to 1:30 in HD and 1:29 to 1:34 in the other patients. The absolute size of the recirculating pool of lymphocytes was 46-90 times 10(9) cells in HD and 100-150 times 10(9) cells in the carcinoma patients.
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PMID:Autotransfusion of 3H-cytidine-labelled blood lymphocytes in patients with Hodgkin's disease and non-Hodgkin patients. II. Exchangeable lymphocyte pools. 80 30

Among 392 cancers histologically diagnosed in Zanzibar during 1957-62 and 1964-67, a definite pattern seems to emerge. Skin and cervix cancers were the most common types in both Africans and Arabs. Skin cancer was predominantly of the squamous cell type. The Zanzibar Arabsthus appear to be protected against basal cell carcinoma which in the Arab desert community has been diagnosed with about the same frequency as squamous-cell carcinoma. In the same manner, the Zanzibar Arab immigrants seem to have a reduced risk for stomach and oesophageal cancers, which are common in other Arab countries. This is probably because Arabs in Zanzibar have adopted the dietary habits and other customs of the Zanzibar Africans in whom cancer of the alimentary tract seems to be uncommon. On the other hand, unlike Zanzibar Africans, the Arabs have an increased risk for Hodgkin's disease similar to that of the Middle East Arab population.
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PMID:Cancer in the Africans and Arabs of Zanzibar. 84 11

Asaley is an L-leucine derivative of sarcolysin which is more active against some rodent tumors. Studies in the USSR demonstrated activity in patients with ovarian and breast carcinoma, Hodgkin's disease, and multiple myeloma. This study in 73 evaluable patients indicated that an appropriate oral dose for patients with adequate bone marrow is 800 mg/M2/day X 4 days at 5-6 week intervals. The most common toxicities were myelosuppression, nausea, and vomiting. Antitumor activity was observed in 2 of 24 evaluable patients with melanoma, and stabilization of previously progressive disease was observed in patients with adenocarcinoma of the colon, multiple myeloma, lymphoma, breast carcinoma, and thyroid carcinoma. Responses were minimal and of short duration but most of the patients had received extensive prior therapy.
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PMID:Clinical evaluation of Asaley. 92 33

Lymph nodes removed from 28 untreated patients with Hodgkin's disease all contained markedly increased amounts of hemosiderine, whether or not they were histologically involved in the disease. This finding was particularly striking in patients with the nodular sclerosis type of disease. Abnormal deposits of iron were also noted frequently in lymph nodes containing metastatic carcinoma, lymphoma of non-Hodgkin's type, and reactive hyperplasia, but in each case, with the exception of metastatic squamous cell carcinoma, the amount was significantly less than seen in Hodgkin's disease. The findings suggest that in patients with Hodgkin's disease and perhaps in those with other disorders in which abnormal tissue retention of iron underlies sideropenic anemia, lymph nodes are an important site of iron retention.
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PMID:Siderosis of lymph nodes patients with Hodgkin's disease. 95 66


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