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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

New aspects concerning the prognostic importance of remission following first treatment and second relapse treatment have resulted from a retrospective study of 175 patients who received primary treatment for Hodgkin's disease between 1964 and 1971. By means of renewed radiotherapy 27 out of 66 (=41%) patients were again brought to full remission with 10 of the 66 (=15%) patients reaching partial remission. The prognosis of the second full remission is equal to that of the first full remission, the prospect of cure being retained. The prognosis of relapse patients following renewed radiotherapy is dependent on: 1. the type of the previous remission, whether full or partial, 2. the localization of the recidive, 3. the primary stage and the presence (or absence) of signs of activity B, 4. the histology, and 5. the age of the patient.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol 1976 Mar 19
PMID:The prognostic significance of first and second remission after first and second relapse radiotherapy in Hodgkin's disease. 13 26

Proliferative responses by blood and tumor lymphocytes to plant mitogens and allogeneic leukocyte antigens were tested concomitantly on 12 patients with Hodgkin's disease, 10 with chronic lymphocytic leukemia, and seven with non-Hodgkin's lymphomas. In 13 control studies, 3H-thymidine incorporation by blood and lymph node lymphocytes was brisk and, overall, comparable. With Hodgkin's disease, where extent of disease involvement and lymphocyte-depleted tumor histology were factors in the degree of responsiveness, incorporation was higher or at least comparable by tumor lymphocytes when compared with incorporation by autologous blood lymphocytes. Lymph node lymphocytes, especially with clinically stable disease, were more responsive than blood lymphocytes with chronic lymphocytic leukemia. Conversely, tumor lymphocytes were hyporesponsive compared with autologous blood lymphocytes with non-Hodgkin's lymphomas, where prognosis is usually less favorable than with chronic lymphocytic leukemia. Plasma from four out of 33 patients, although not lymphocytotoxic, inhibited lymphoproliferative responses.
Cancer 1976 Aug
PMID:Reactivity of lymphocytes from primary neoplasms of lymphoid tissues. 13 38

A review is given on laparoscopic possibilities in the differentiation of tumours of the liver. Benign lesions are rare and usually discovered by chance. Primary cancer of the liver can be verified ante finem in a maximum of 40% of the cases. Characteristic is the endoscopic picture in the case of haemangiosarcoma after arsenic, Thorotrast, vinyl chloride (marked capsular fibrosis, net-like marking, "restless" surface of theliver). All the tumours need to be confirmed histologically. A tumour-like appearance is presented by echinococcus alveolaris and coarse-nodular granulomatous changes (sarcoidosis, lymphogranulomatosis, etc.).
 ...
PMID:[Liver tumors. Laparoscopic aspects]. 13 11

In 75 patients with non-Hodgkin Lymphomas the influence of the histopathological form, as judged by the Kiel classification, on the epidemiology and prognosis of the disease was examined retrospectively. The different forms of the Kiel classification influence in a typical way the age specific incidence rates and the prognosis of the disease.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol 1976 Dec 09
PMID:Preliminary clinical findings on the Kiel classification of malignant lymphomas. 13 71

In a series of 121 unselected, previously untreated patients with Hodgkin's disease staging laparoscopy combined with needle bone marrow biopsy detected the presence of extranodal disease in the liver or marrow or both in 9% of the patients. A spleen biopsy yielded positive findings in 13%. Subsequent laparotomy with open marrow biopsy performed in 110 patients with negative liver and marrow findings from the first combined procedure revealed the presence of extranodal hepatic lymphoma in two additional spleens. Surgical marrow biopsy was always interpretey. Although devoid of major complications, biopsy of the spleen is not recommended as a routine procedure in staging laparoscopy. This prospective sequential study confirms that laparoscopy plus needle marrow biopsy is a useful, rapid, safe, and economic procedure to establish stage IV disease in the large majority of patients with nodal involvement. Considering the recent more extensive use of chemotherapy for intermediate stages of Hodgkin's disease, our findings suggest that laparotomy with splenectomy needs a critical re-evaluation as a routine staging procedure for patients with no overt extranodal lymphoma.
Cancer Treat Rep 1976 Sep
PMID:Sequential laparoscopy and laparotomy combined with bone marrow biopsy in staging Hodgkin's disease. 13 79

Re-evaluating 327 Hodgkin's disease biopsy specimens, 10 cases with dense eosinophilic infiltration, amounting to more than 50% of the cell population, have been found. This phenomenon of eosinophilic predominance, occurred mainly in the fibrotic types of Hodgkin's disease. The survival time of patients with eosinophilic predominance was significantly shorter than that of the controls. The possible role of eosinophils in Hodgkin's disese has been discussed.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol 1977 May 20
PMID:Eosinophil predominance in Hodgkin's disease. 14 95

Four hundred and fifty two cases of Hodgkin's disease (H.D.) were studied in Medellin, Colombia, following the Rye histological classification: The relative frequency of H.D. was 2.3% for all malignancies and 34% for the solid lymphoreticular tumors. The percentage of H.D. in children as compared with adults was 27%, which is higher than usually reported. The age curve of incidence was bimodal with a first high peak at age 5--9 years and a lower second peak between 15--25 years. Males predominated mainly in children, 4.5--1. The epidemiological pattern for H.D. in our area generally corresponded with the Type I recently described for developing countries; but a high frequency for Nodular Sclerosis in children, with unusual anatomical localizations, more severe clinical manifestations, and poorer prognosis seems to indicate complex factors in the etiopathogenesis of the disease in the same geographical area.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol 1977 Aug 15
PMID:Hodgkin's disease in Medellin, Colombia. 14 12

Twenty-four patients with far advanced malignant tumors, resistent to established chemotherapy,, were treated with the combination of MNU and Cyclophosphamide. The drugs were administered in six-day cycles sequentially. MNU in doses of 4 mg/kg body weight and Cyclophosphamide in doses of 8 mg/kg body weight were given. Results of treatment showed response (greater than 50% tumor regression) in 10 (42%) of the 24 treated patients. Seven remissions were complete and three partial. Patients with Hodgkin's disease, malignant melanoma and breast cancer responded to this combination chemotherapy. Objective remissions were obtained also in five of thirteen patients with primary or metastatic brain tumors and in five of nine patients with pulmonary metastases. Nausea and vomiting were the main toxic effects, especially after injections of MNU. Myelosuppression was noted in about 50% of treated patients. Since this combination of cytostatics showed significant antitumor activity, further investigations are necessary on a larger number of patients and in other types of malignant tumors.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol 1977 Aug 15
PMID:Combination chemotherapy with 1-methyl-1-nitrosourea (MNU) and cyclophosphamide in solid tumors. 14 13

The long term alterations of T and B lymphocytes in the peripheral blood of patients treated with regional irradiation for various malignancies were examined. Eighty patients were tested at various intervals after the completion of irradiation. Absolute lymphocyte counts, the percentages of T cells and B cells, and the blastogenic response to phocyte reaction (MLR) were determined. Nearly all patients initially had absolute lymphocytopenia and one-third of the patients tested 3 years after completion of irradiation had lymphocyte counts which were more than two standard deviations below the normal range. The depression was not specific for either the T-or B-lymphocyte subpopulations. The PHA response was impaired for extended periods of time after the completion or irradiation. Differences in the mean response of lymphocytes to PHA were noted for all concentrations of the mitogen, but were most marked with suboptimal concentrations of PHA. The MLR was below the lower limits of normal in 70% of the recently irradiated patients. There was a gradual recovery of the ability to respond in the MLR, and all patients tested more than 4.5 years after the completion of therapy had a normal response. These results were compared with those obtained in patients treated with total lymphoid irradiation for Hodgkin's disease. Although three appeared to be a difference in the effect of radiation on lymphocyte subpopulations in the two groups, the effects on lymphocyte function were similar.
Cancer 1977 Nov
PMID:The long term effects of radiation of T and B lymphocytes in the peripheral blood after regional irradiation. 14 54

The preferred histopathological classification of Hodgkin's disease (HD) is that suggested by Lukes and Butler as modified at the Rye Symposium; the histologic subtypes are highly reproducible and correlate well with the anatomic sites of involvement, clinical stage, and survival. The accuracy of the bipedal lymphangiogram, 67gallium scan, and ultrasonography in predicting abdominal involvement by HD is 90% , 50%, and 88%, respectively. Staging laparotomy remains the most accurate method of detecting intra-abdominal disease and has added immensely to new concepts in the management of HD. These concepts suggest that patients with nodal disease limited to the celiac axis or upper para-aortic areas (substage III1) or pathologic stage (PS) IIIS+N-A, when treated with extended field radiotherapy alone have survival rates comparable to PS IIA patients. In contrast, patients in PS IIIA with lower abdominal nodal disease (substage III2), regardless of splenic involvement, have a prognosis comparable to PS IV disease. Thus, there may only be two stages of HD, those curable with extended mantle or smaller radiotherapy fields alone, and those requiring chemotherapy with or without supplemental radiotherapy.
Cancer 1978 Aug
PMID:Hodgkin's disease: problems of staging. 15 Sep 39


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