Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

148 cases of parotid gland tumours which had been treated during the last 15 years were analysed histomorphologically: There was found in 54.1% mixed tumour (pleomorphic adenoma), 11.5% epithelial malignant tumour, 4.1% sarcoma, 7.4% primary metastasis, 22.9% other benignant tumours. In 2.5% of 80 cases of mixed tumour a malignant degeneration was revealed. Some cases of double tumours and more seldom tumours as for instance lymphoepithelioma and malignant papillary cystadenoma are presented. A critical appraisal of primary sarcomas is following, but also a comment to the problem of primary metastasis in the parotid gland. The author's opinion is now: favourable therapeutic results can be reached in cases of small and modestly enlarged mixed tumours by means of the so-called "extracapsular" or "extended extracapsular" removal on the understanding that a critical casuistic choice was made and a skilled surgical procedure was applied. On this way relapses have been observed in 2.6% of the author's cases till now. A five years survival time of epithelial malignant tumours was found in 17.7% (88.2% of all epithelial malignant tumours had been treated at stage III and IV). All patients suffering from a sarcoma died within a period of 1/2 to 3 1/2 years after therapy except a case of Hodgkin's sarcoma (8 1/2 years). Primary metastasis in the parotid gland in cases of malignant tumours of head and skull sometimes was discovered in the author's cases, the infavourable prognosis of which was similar to primary malignant tumours at all.
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PMID:[Tumours of the parotid gland--results of their treatment and some peculiarities (author's transl)]. 13 50

Warthin's tumor, classed as a monomorphic adenoma, ranks second to pleomorphic adenoma in the incidence of benign neoplasms of the parotid gland. By embryologic and clinicopathologic definitions, it is a neoplasm of the parotid gland and its environs, including parotid lymph nodes. Histopathologic diagnosis requires an oncocytic (mitochondria-rich) epithelium and lymphoid stroma. Malignant Warthin's tumors are rare and are carcinomas arising from the ductal component, or non-Hodgkin's lymphomas arising from the lymphoid tissue.
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PMID:Warthin's tumor. 219 65

A 53-yr-old man with hypercalcemia was referred after an unsuccessful operative attempt to find a parathyroid adenoma. Metabolic evaluation showed relatively suppressed levels of parathyroid hormone with an elevation of serum 1,25-dihydroxyvitamin D. Thallium-technetium dual isotope imaging revealed localized mediastinal thallium uptake. A vascular mediastinal lesion was then demonstrated by arteriography, with subsequent surgical removal of a mass that proved to be lymphocyte predominant Hodgkin's disease. This case is noteworthy for the finding of isolated lymphocyte predominant Hodgkin's disease in the chest, the association of elevated serum 1,25-dihydroxyvitamin D with hypercalcemia that resolved postoperatively, and the uptake of thallium by the tumor.
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PMID:Hodgkin's disease with hypercalcemia detected by thallium-201 scintigraphy. 302 84

Malignant lymphoma of the parotid gland region, especially Hodgkin's disease of the gland, is an extremely rare disorder. We have recently experienced a case initially suspected of being pleomorphic adenoma and later, on postoperative histopathological examination, diagnosed as Hodgkin's disease. The present report describes this case of Hodgkin's disease arising from an intraglandular lymph node in the parotid gland.
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PMID:A case of Hodgkin's disease arising from an intraglandular lymph node in the parotid gland. 334 11

The reported relationship of radiation exposure and thyroid carcinoma stimulated this retrospective study of 298 patients treated at St. Jude Children's Hospital with radiation therapy to the neck for childhood cancer to identify patients who developed subsequent thyroid abnormalities. This series includes 153 patients with Hodgkin's disease, 95 with acute lymphocytic leukemia, 28 with lymphoepithelioma, and 22 with miscellaneous tumors. Inclusion in the study required 5 years of disease-free survival following therapy for their original tumor, which included thyroid irradiation. Follow-up has been 100%. Most patients also received chemotherapy. Seventeen patients were found to have decreased thyroid reserve with normal levels of free triiodothyroxine (T3) or free thyroxin, (T4) and an elevated level of thyroid-stimulating hormone (TSH). In nine patients hypothyroidism developed, with decreased T3 or T4 levels and an elevated level of TSH. One hyperthyroid patient was identified. Two patients had thyroiditis, and seven had thyroid neoplasms: (carcinoma in two, adenoma in two, colloid nodule in one, and undiagnosed nodules in two). This survey has demonstrated an increased incidence of thyroid dysfunction and thyroid neoplasia when compared to the general population. The importance of long-term follow-up for thyroid disease is emphasized in patients who have received thyroid irradiation. The possible role of subclinical hypothyroidism with TSH elevation coupled with radiation damage to the thyroid gland as a model for the development of neoplastic disease is discussed.
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PMID:Thyroid dysfunction and neoplasia in children receiving neck irradiation for cancer. 385 82

A 38-year old man developed hypercalcaemia 13 years after treatment with mantle field radiation for Hodgkin's disease. A parathyroid tumour was removed surgically. The histological diagnosis was parathyroid adenoma with marked central fibrosis. Hyperparathyroidism as a possible late complication of radiation therapy of malignant diseases has, to our knowledge, not been described before. Key words: Hodgkin's disease, hyperparathyroidism, irradiation, parathyroid adenoma.
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PMID:Hyperparathyroidism after neck irradiation for Hodgkin's disease. 642 67

A 66-year-old man presented with a primary malignant lymphoma of the cerebellum and brain stem. The lymphoma was of type V (Bryon's classification) with predominant B cells, and was associated, as in previously reported cases, with a peripheral blood T lymphocyte deficiency. This case was unusual, in that autopsy revealed an active multivisceral sarcoidosis (considered as being cured more than 10 years previously), a clear-cell renal adenoma demonstrating nearly all the characteristics of a Grawitz's tumor, and a papillary epithelioma of the thyroid gland. These findings lead to discuss the significance of immuno-surveillance lack in this particular case: was it dependent on the sarcoidosis (during which a reduction in T lymphocytes is known to occur), or was it primary and perhaps genetic, a son of the patient having Hodgkin's disease? Whatever the case may be, the encephalic proliferation of the B lymphocyte clone, the peripheral epitheliomas, the sarcoidosis, and the deficit in T lymphocytes in the peripheral blood constitute a group of factors singularly rich in questions, this being, apparently, the first case of this type reported in the published literature.
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PMID:[Primary non-Hodgkin's lymphoma of the brain, sarcoidosis, thyroid cancer and immunity cell deficiency (author's transl)]. 705 Dec 23

Ten undifferentiated thyroid carcinomas detected between 1976 and 1991, were reviewed by means of immunohistochemical techniques. These tumors were highly aggressive with a mean survival rate of three months after the histological diagnosis. They were predominant in women and always occurred in old people (mean age 63.1 years). Four tumours were composed of differentiated trabecular areas. Another one was included in a microvesicular adenoma and a sixth one occurred as a recurrence of a papillary carcinoma surgically treated four months previously. Six tumours were cytokeratin-positive and two of them showed a cytokeratin-vimentin coexpression. These results, like those of an electron microscopic analysis of 1 case, confirm the epithelial origin of these tumours. Undifferentiated carcinomas must be distinguished from poorly differentiated carcinomas and from malignant non Hodgkin lymphomas which have a better prognosis and a different therapeutic approach. The immunohistochemistry and the electron microscopy are useful to identify undifferentiated thyroid carcinomas.
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PMID:[Undifferentiated carcinomas of the thyroid corpus. Apropos of 10 cases]. 827 54

Forty-five patients with oral or pharyngeal swellings were subjected to fine needle aspiration cytology (FNAC) of the mucosal surface over eight years. The age of the patients ranged from 2 to 85 years. The male:female ratio was 25:20. The common sites of involvement were palate (16 cases), cheek (9), pharynx (7) and tonsillar/peritonsillar area (6). Tongue, maxilla, alveolus and lips were less frequently involved. FNAC played an important role in differentiating inflammatory from neoplastic lesions and also benign from malignant neoplasms. Fifteen cases were cytologically diagnosed as benign neoplasms and included pleomorphic adenoma (11 cases), schwannoma (2), odontogenic tumor (1) and benign neoplasm not otherwise specified (1). Sixteen cases were diagnosed as malignancies. There were seven cases of malignant salivary gland tumors and 6 of squamous cell carcinoma. Two cases were high grade non-Hodgkin's lymphomas, and one was malignant odontogenic tumor. Of the 11 inflammatory or reactive lesions, 4 were found to be harboring Actinomyces. The rate of inadequate sampling was 6.7%. Histopathology reports on excised tissue were available for 10 cases only. Seven of nine cases with adequate cytology (77.88%) showed complete agreement with histology.
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PMID:Fine needle aspiration cytology of oral and pharyngeal lesions. A study of 45 cases. 838 7

The occurrence of multiple tumours in the salivary glands is an unusual phenomenon and the simultaneous development of tumours different types is extremely rare. Two cases are presented with synchronous tumours of the parotid gland of different histological types. The first was a Warthin tumour in combination with a metastatic lung carcinoma and the second was a pleomorphic adenoma in combination with non-Hodgkin's malignant lymphoma.
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PMID:Synchronous unilateral parotid neoplasms of different histological types. 1038 49


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