Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A new four-drug combination chemotherapeutic regimen (BVDS) was used in the treatment of advanced Hodgkin disease resistant to MOPP (mechlorethamine hydrochloride, vincristine sulfate, procarbazine hydrochloride, and prednisone). The BVDS regimen, consisting of 12 cycles of bleomycin sulfate, vinblastine sulfate, doxorubicin hydrochloride (Adriamycin), and streptozocin (streptozotocin), was administered to ten patients. Responses were seen in five (50%) of these patients. Complete remissions occurred in three (30%). These results suggest that BVDS is an effective alternative regimen to MOPP, and may be of benefit not only to patients resistant to MOPP, but also to newly-diagnosed patients with advanced hodgkin disease when combined sequentially with MOPP.
JAMA 1977 Jan 03
PMID:A new combination chemotherapy for resistant Hodgkin disease. 6 54

Peritoneoscopy was used to evaluate the liver in 35 previously untreated patients with Hodgkin disease. Four were found to have hepatic involvement. Of the 31 patients with normal peritoneoscopies, only one had liver disease demonstrated subsequently at confirmatory exploratory laparotomy. The diagnostic accuracy of peritoneoscopy was 93% for patients at high risk for hepatic disease and 97% for all patients studied. Morbidity from the procedure was minimal. There was no mortality. Peritoneoscopy is a highly accurate staging procedure that should be considered as an antecedent or as an alternative to laparotomy in patients with Hodgkin disease. Its accuracy and minimal morbidity should be considered in the critical selection process of determining which individuals should undergo laparotomy.
JAMA 1976 Dec 06
PMID:Peritoneoscopy in Hodgkin disease. Confirmation of results by laparotomy. 13 25

Histologic sections of spleen and liver prepared from tissue obtained during exploratory laparotomy and splenectomy in 91 untreated patients with Hodgkin disease were reviewed to assess the incidence and possible implications of noncaseating, epitheliod, sarcoid-like granulomas. The 17 patients with granulomas and the 74 patients without granulomas did not differ appreciably with respect to pretreatment indexes. All patients were observed for at least 15 months following laparotomy or until the time of death (range, 15 to 67 months; median, 25 months). The 17 patients with granulomas tended to have fewer relapses, longer survival, and lower incidence of subsequent herpes zoster infection compared to the 74 without granulomas. The presence of epithelioid granulomas in association with Hodgkin disease may reflect a host response to the tumor with favorable prognostic implications.
JAMA 1975 Aug 25
PMID:Epithelioid granulomas in Hodgkin disease. A favorable prognostic sign? 16 15

Two cases of candidiasis occured in the stomach. The first is a case of disseminated candidiasis with stomach wall involvement. The patient had Hodgkin's disease and responded to chemotherapy and amphotericin B. The second is a case of superficial invasion of Candida in a stitch ulcer. Systemic and local factors influence growth of Candida in the stomach.
JAMA 1978 Nov 10
PMID:Gastric candidiasis. 30 11

Forty-one women with advanced Hodgkin's disease were studied to determine the effect of combination chemotherapy on fertility and ovarian function. Histories and pretreatment ovarian biopsy specimens indicated normal fertility before therapy, thus implying no adverse effect of Hodgkin's diseases on female gonadal function. Ovarian activity was assessed after therapy by menstrual history, serial basal body temperatures, and hormonal levels. Each case was assigned to one of three categories: primary ovarian failure (failed ovary), irregular ovarian activity (failing ovary), and normal cyclic ovarian activity (functioning ovary). After therapy, 20 of 41 patients (49%) were categorized as failed, 14 (34%) as failing, and only 7 (17%) as functioning. In 16 months of further observation, progressive loss of ovarian function occurred that was clearly age related but not statistically dose related. Induction of premature, irreversible menopause presents a need for effective hormonal replacement and patient counseling.
JAMA 1979 Oct 26
PMID:Cytotoxic-induced ovarian failure in women with Hodgkin's disease. I. Hormone function. 48 Jun 20

Chemotheraphy for Hodgkin's disease produces ovarian failure in young women. The consequences of this are emotional distress, sexual dysfunction, and the disruption of families and friendships. These previously unappreciated side effects of cytotoxic therapy had developed in 25 of 41 patients, among whom we conducted a retrospective study.
JAMA 1979 Oct 26
PMID:Cytotoxic-induced ovarian failure in Hodgkin's disease. II. Effects on sexual function. 48 Jun 21

Castration commonly appears to be the price of "cure" in patients treated with chemotheraphy for Hodgkin's disease. Awareness and anticipation by the physician, with appropriate counseling of the patient on the profound psychological and emotional changes occasioned by chemotherapeutic treatment, may provide benefit both in terms of acceptance of therapy and in adjustment of changes in interpersonal relationships. From this point, attention should be directed to (1) replacement of evident hormonal deficiency, (2) artificial preservation of viable germ cells, and (3) means of avoidance of germ cell damage by chemotherapy.
JAMA 1979 Oct 26
PMID:Cytotoxic chemotherapy and gonadal function in patients with Hodgkin's disease. Facts and thoughts. 48 Jun 26

A patient with Hodgkin's disease also had anemia, hypochromia, and thrombocytosis, which were clues to an otherwise silent relapse. These features were corrected following chemotherapy. Repeated lymphangiography is shown to be of value in diagnosis.
JAMA 1977 Sep 19
PMID:Hematologic changes in a patient with Hodgkin's disease in relapse. 57 77

Endobronchial involvement with Hodgkin's disease has been reported infrequently. A 26-year-old woman with previously diagnosed nodular sclerosing Hodgkin's disease had substernal chest pain and a right middle lobe infiltrate. Fiberoptic bronchoscopy showed nodular endobronchial lesions located at the carina, the right mainstem bronchus, and the right middle lobe orifice. A biopsy specimen of one of these lesions showed Hodgkin's disease. The patient was then treated with sequential systemic chemotherapy. Repeated bronchoscopy showed complete resolution of the endobronchial lesions, and the patient has remained in complete remission for 24 months.
JAMA 1978 Mar 13
PMID:Endobronchial Hodgkin's disease. 62 53

Retrospective analysis of 232 cases of Hodgkin's disease (HD) treated at the University of Manitoba from Jan. 1, 1965, to Dec 31, 1973, and followed up to 44.3 months disclosed five cases of secondary malignant neoplasms. Two cases of acute leukemia were discovered compared with an expected value of 0.05 in our community. All neoplasms developed in the mixed cellularity group, representing only 28% of the HD cases. Combinations of radiotherapy and chemotherapy may have increased the incidence of leukemia, but its frequency does not appear high enough to abandon combined modality treatment.
JAMA 1978 Jun 09
PMID:Secondary malignant neoplasms in patients with Hodgkin's disease. 65 Aug 29


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