Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Between May 1984 and October 1995 we performed 114 autologous stem cell transplants for lymphoma in our centre; 77/114 (68%) were transplanted after primary therapy. The conditioning regimen varied according to diagnosis; 26 patients were conditioned with melphalan and total body irradiation, 66 received melphalan and etoposide and the remainder (50) were conditioned with melphalan alone. The median follow-up is 62 months. Only two new haematological malignancies have occurred, both in patients with Hodgkin's disease. One patient developed Ph+ chronic myeloid leukaemia 18 months post-transplant. In this case, because of the timing of the haematological disorder, we considered the malignancy to be concurrent with or to have preceded the transplant. A second patient developed acute myeloid leukaemia 20 months post-transplant. She had been treated for Hodgkin's disease for 10 years and was transplanted in third complete remission. Cytogenetic analysis in this case showed trisomy 11. We believe this to have been an unequivocal second malignancy. Our finding of a 1.1% incidence of secondary haematological malignancy (95% CI 0.02-4.96) from a census population adds weight to the hypothesis that haematological problems post-transplant reflects prior chemotherapy rather than toxicity from the transplant procedure itself.
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PMID:Low incidence of myelodysplastic syndrome following transplantation using autologous non-cryopreserved bone marrow. 932 84

A case of non-Hodgkin malignant lymphoma of the lung was presented with a review of Japanese literatures. A 53-year-old woman was referred to our hospital because of an abnormal shadow on the roentgenogram of mass screening, with neither subjective symptoms nor abnormalities in physical examinations. Laboratory tests showed normal values. The diagnosis of pulmonary malignant lymphoma was obtained by immunohistochemical examinations. She underwent a upper lobectomy of the left lung with lymph nodes dissection of the mediastinum. The histological immunohistochemical and diagnosis of the resected tumor was primary pulmonary B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) without regional lymph nodes involvement. She has been doing well without any signs of recurrence for 15 months after the operation.
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PMID:[Primary pulmonary malignant lymphoma of mucosa-associated lymphoid tissue (MALT)--a case report with a review of Japanese literatures]. 934 Dec 71

The case of an 11-year-old girl with mediastinal stage III B-E Hodgkin's disease is described. She achieved complete remission with combined chemoradiotherapy according to the Swiss Pediatric Oncology Group-HD Protocol 1985. Six months after all therapy was stopped, a slowly growing retrosternal mass was detected. Computed tomography (CT) and gallium-67 single-photon emission CT (SPECT) could not elucidate the true origin of the tumor, nor did ultrasound-guided transthoracic fine-needle puncture. Open biopsy with histologic examination of the lesion has successfully identified the mass as thymic hyperplasia, a rebound immunologic reaction after chemoradiotherapy that mimicked tumor regrowth.
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PMID:Recurrent mediastinal mass in a child with Hodgkin's disease following successful therapy: a diagnostic challenge. 935 39

Primary Hodgkin's disease in the bone is extremely rare. We report the case of a 41-year-old woman with Hodgkin's disease, who had complained of left coxalgia 17 months prior to nodal involvement becoming evident clinically. She received combination chemotherapy with doxorubicin, bleomycin, vincristine and dacarbazine as well as radiotherapy to the pelvic lesion. Although the lymphadenopathy responded well to this treatment, the bone lesion was never in remission. The large mass of the bone lesion and its pelvic origin may explain the poor response to the cytotoxic therapies this patient received. The 22 cases reviewed showed that: 1, bony pain was the most frequent initial symptom; 2, nodal disease appeared in their clinical course in most cases; 3, the bones most commonly involved were pelvis, femur or tibia, and spine.
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PMID:Coxalgia as the initial symptom in Hodgkin's disease: a case report. 939 Feb 17

Judith Thwaite discusses the role of complementary therapy in her treatment for non-Hodgkins lymphoma. She was diagnosed with non-Hodgkins lymphoma in 1988 and since that time she has tried a number of therapies. A visit to the Bristol Cancer Help Centre changed her outlook on life and the Centre's policy of patient empowerment encouraged her to fulfil an ambition to write. She also visits the Royal Homoeopathic Hospital, London, regularly for massage, shiatsu, acupuncture, and reflexology and relates how these have helped her cope with the disease as well as her sessions of chemotherapy. Throughout her illness she has remained positive and optimistic, determined to use whatever methods that are available to help her.
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PMID:Complementary therapies: a patient's choice. 943 79

Occurrence of Non Hodgkin's lymphoma (NHL) in pregnancy is very rare. A 24-year-old woman with NHL stage IVB complicating pregnancy is presented. The diagnosis was made by biopsy at 27 weeks. The patient received combination chemotherapy which led to remission of the disease. The baby was delivered by an emergency caesarean section, due to fetal distress at 31 weeks. Unfortunately after a short period of remission a relapse occurred and magnetic resonance imaging (MRI) showed cerebral involvement, indicating a poor prognosis. She died seven months later from disseminated disease.
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PMID:Non-Hodgkin's lymphoma during pregnancy--case report. 964 12

Primary malignant lymphomas of the bladder are infrequent. We report a 70 year old woman presenting with hematuria, dysuria, malaise and a 5 kg weight loss. Pelvic ultrasound examination showed a 8 x 8 x 8 cm solid and cystic mass adjacent to the bladder and uterus. Cystoscopic biopsy disclosed a low grade B cell non Hodgkin lymphoma. She was treated with 6 cycles of chemotherapy with disappearance of the mass. Two years after admission, the patient is free of disease.
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PMID:[MALT lymphoma of the bladder: report of a case]. 965 57

We present a case of asynchronous development of transitional cell carcinoma in urinary bladder and renal pelvis after prolonged cyclophosphamide therapy. A 57-year-old woman had received 290 g cyclophosphamide for 13 years because of therapy for non-Hodgkin lymphoma. She was suffered from dysuria and macrohematuria and visited our clinic. Cystoscopy, CT and MRI revealed invasive bladder tumor and total cystectomy was performed. Histological diagnosis was transitional cell carcinoma, G3 < G2, pT4. Six months after the cystectomy, a follow up urography and computerized tomography showed left renal pelvic tumor. The patient underwent total nephroureterectomy, and the histological diagnosis was transitional cell carcinoma, G3, pT3. We reviewed cyclophosphamide induced urothelial carcinomas from Japanese and world literatures.
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PMID:[Cyclophosphamide induced urinary bladder and renal pelvic tumor--a case report]. 973 90

We report 2 cases of agranular CD2- CD4+ CD56+ non-Hodgkin lymphoma in which skin seemed to be the primary site. A 21-year-old woman's initial symptom was a skin nodule on the right cheek. She also had tumors in the nasopharynx, and the bone marrow subsequently became involved. No lymphadenopathy was present. She experienced complete remission after dose-intensified therapy with cyclophosphamide, hydroxydaunomycin, vincristine [Oncovin], and prednisone (CHOP), but the disease relapsed in the central nervous system 6 months later. An 81-year-old man experienced an 11-month history of skin nodules in the left forearm. On admission, he had a bone marrow infiltration of lymphoma cells. He died of pneumonia during chemotherapy. The malignant cells of the 2 patients had similar morphologic features, with a monocytoid nucleus and no cytoplasmic granules. The cells in both cases showed a unique phenotype: CD2-, CD3-, CD4+, CD8-, CD13-, CD14-, CD34-, CD16-, CD56+, CD57-, HLA-DR-positive. Staining for peroxidase and alpha-naphthyl butyrate esterase was negative. The T-cell receptor beta, gamma, delta, IgH, kappa, lambda genes were of germ line configurations. The DNA of Epstein-Barr virus was not detected from the bone marrow cells by polymerase chain reaction. Only 3 other cases with similar phenotypes have been reported; all had skin lesions. Although the origin of these cells remains unknown, we propose that this is a distinct clinicopathologic entity.
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PMID:A cutaneous agranular CD2- CD4+ CD56+ "lymphoma": report of two cases and review of the literature. 1043 11

The primary cardiac lymphoma is extremely rare. A case is presented of a 60 year old female patient with non-Hodgkin lymphoma of probable primary cardiac localization and with subsequent extension to peripheral lymph nodes. She had had a febrile syndrome for 8 months. Two two-dimensional echocardiograms gave negative results. Due to a syncope with atrial fibrillation, a transesophageal echocardiogram was carried out, which showed tumors in both atria, interatrial septum and right ventricle. The later appearance of right preauricular lymph nodes and left supraclavicular nodes led to a biopsy which confirmed a diagnosis of diffuse non-Hodgkin lymphoma with large immunoblastic cells. The patient died 15 months after the first symptoms, having undergone 6 chemotherapy cycles. The autopsy showed remission of the macroscopic lesions but presence of microscopic lesions in the cardiac chambers with histology and phenotypic markers identical to the ones found in the lymph nodes.
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PMID:[Cardiac primary lymphoma]. 1034 68


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