Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019829 (Hodgkin's disease)
 30,247 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Total-body scintigraphy with 111In-labeled bleomycin was performed in 66 patients with malignant solid tumors and systemic diseases of the lymphatic pathways (Hodgkin's lymphoma and non-Hodgkin's lymphoma). In 38 (58%) of 66 cases positive information was correct. In 12 (18%) of 66, scintigraphic information was correctly negative. With 16 out of 66 (24%), false positive or false negative informations were obtained.
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PMID:[Localization diagnostics of malignant tumors using radioactive bleomycin (author's transl)]. 6 44

A case of eosinophilic meningitis as a complication of Hodgkin's disease is reported. Intrathecal chemotherapy with methotrexate and whole brain radiation therapy were effective in clearing the cerebrospinal abnormalities, pathologic evidence of meningeal disease, and the clinical manifestations. The differential diagnosis of eosinophilic meningitis and therapy of lymphomatous meningitis are discussed.
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PMID:Eosinophilic meningitis complicating Hodgkin's disease. A report of a case and review of the literature. 6 84

Presence of alfa-fetoprotein was found in serum of patient in whom primary hepatoma was suspected. The post-mortem microscopical examination did not confirm the clinical diagnosis ut showed changes typical for Hodgkin's disease.
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PMID:[Alpha fetoproteins in serum of a patients with Hodgkin's disease]. 7 Jan 50

Similarities have been observed for some time between oncornavirus-induced malignancies in laboratory animals and leukemias and solid tumors in man. Particles similar to type C oncornaviruses have been detected by electron microscopy both in cells or plasma from leukemia patients and in solid-tumor human malignancies such as Hodgkin's lymphoma, lymphosarcomas, and sarcomas. Likewise, particles resembling type B oncornaviruses in shape and appearance have been found in human breast cancer. In neither case has the infectious nature of the particles been confirmed. However, DNA synthesized in vitro by the enzyme of murine mammary tumor virus was found to hybridize with polysomal RNA obtained from human mammary adenocarcinomas. The presence of RNA complementary to RNA from the Rauscher strain of murine leukemia virus has been observed in other human malignancies unrelated to breast cancer. It has also been found that cells of patients with myelogenous leukemia possess an oncornaviral-type reverse transcriptase that is distinguishable from other cell DNA polymerases and serologically related to the reverse transcriptase of primate oncornaviruses.
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PMID:Human studies following animal models of tumorigenesis by oncornaviruses. 7 Nov 81

A detailed review of our results of radiotherapy for stage I and II non-Hodgkin's lymphomas has been presented as background for our current multidisciplinary approach which uses multiple-agent chemotherapy, radiotherapy, and immunotherapy for nodular and diffuse stage I, II, and III lymphomas of the poorly differnetiated lymphocytic, mixed, and histiocytic varieties. Optimum management is based on coordinated efforts of medicine, radiotherapy, pathology, diagnostic radiology, and surgery. In stage I, II, and III disease, routine staging procedures include lymphangiography, bilateral iliac crest needle biopsies of the bone marrow, and percutaneous needle biopsies of the liver. Staging laparotomy is considered essential to our present program for stage I, IE, II and IIE disease. In our opinion, staging laparotomy is not indicated in stage II or IIIE disease. Although very preliminary, results for these programs are encouraging. This paper presents the concept of team management and a specific plan for its implementation.
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PMID:Team approach to management of non-Hodgkin's lymphomas: past and present. 7 Dec 10

Immunofluorescence staining was applied to tissue with primary nonhepatic malignancies and/or their metastatic nodules in the liver. Tumor cells from the primary sites of two patients with carcinoma of the pancreas and one patient with Hodgkin's disease were found to be positive for alpha-fetoprotein (AFP). In five patients with gastrointestinal tract cancer, and two with nongastrointestinal tract carcinoma, the liver cells immediately adjacent to the metastiatic foci were positive for AFP. Negative results for AFP was found in seven patients with liver metastasis; of these seven patients, five had nongastrointestinal tract cancer, and two had cancer that arose in the gastrointestinal tract. It is unclear what influences the production of AFP in cases of liver metastasis, since some neoplasms from the same organ system do provoke this phenomenon, and others do not.
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PMID:Localization of alpha-fetoprotein synthesis in malignancies other than hepatoma. 7 86

The correlation of enzymatic activities studied at different periods of time (lasting from several hours to several days) has been revealed in 39 children at different stages of acute leukemia and in 8 children suffering from other hematological diseases (Hodgkin's disease, Morbus Werlhof, reactive reticulosis). The correlation of activity of enzymes constituting different systems and arranged in different parts of cell organelles enables us to explain this phenomenon by a regulation on a higher level, viz. cytophysiological processes as a whole. The coordination of enzymes possible depends on the synchronism of enzymatic activity caused by the physiological process developing in the cell.
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PMID:Time-conditioned coordination of dehydrogenase activity in blood cells in infantile acute leukemia. 7 21

Human ribonucleases were purified from the sera of Hodgkin's disease patients by sequential column chromatography. The purified enzyme interacted with reverse transcriptase of Rauscher leukemia virus and formed an additive complex of Mr = 130,000. RNase and oligo(dG)-directed reverse transcriptase activities were diminished in the complex. The complex could be dissociated with the subsequent restoration of both activities in the presence of spermidine. The molecular weight of the complex suggest that the 2 RNase molecules bind to a single reverse transcriptase molecule.
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PMID:Complexing Rauscher leukemia virus reverse transcriptase with human plasma ribonuclease from Hodgkin's disease patients. 7 69

Three patients with acute lymphoblastic leukaemia are reported in whom Hodgkin's disease developed during chemotherapy-maintained remission. This association has been reported only once before. The pathogenesis of the Hodgkin's disease in these patients is discussed, including the possible role of anti-leukaemic therapy.
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PMID:Hodgkin's disease occurring during acute leukaemia in remission. 7 42

A 26-year-old white man with stage 4-B Hodgkin's disease resistant to conventional chemotherapy obtained complete remission with administration of bleomycin. Maintenance of this remission required continued therapy with bleomycin. The patient received a total of 2,700 units of bleomycin over a 51-month period without signs or symptoms of pulmonary toxicity. Serial studies of pulmonary function have shown a stable forced vital capacity and minimally decreased total lung volume and pulmonary diffusing capacity. This case demonstrates the ability of a patient to tolerate massive cumulative doses ob bleomycin over a protracted period without severe loss of pulmonary function.
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PMID:Prolonged administration of bleomycin without clinical toxicity. Therapy with 2,700 units over four years. 7 36


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