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Query: UMLS:C0019693 (HIV)
 170,526 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It has been suggested that the introduction of spermatozoa to the rectum leads to the development of a humoral immune response. The immunobead method was used to investigate antisperm antibody titre and prevalence and their relation to HIV status in 60 homosexual men attending the Royal Melbourne Hospital (Australia) HIV/AIDS clinic as part of an ongoing epidemiologic study. On the basis of their sexual practices in the preceding 6 months, the men were categorized into four groups: Group 1--unprotected oral intercourse only (n = 13), Group 2--unprotected oral and anal intercourse (n = 39), Group 3--unprotected anal intercourse only (n = 2), and Group 4--celibate (n = 6). Antibodies to sperm were found in the sera of 6 men (10%), all of whom were from Groups 2 and 3. Thus, the prevalence of antisperm antibodies in men who had practiced unprotected anal receptive intercourse in the preceding 6 months was 17%. Antibodies were of the IgG and IgA isotypes. There was no correlation between the presence of antisperm antibodies and antibodies to HIV or numbers of T lymphocytes. 30 men, including 2 of the 6 men with antisperm antibodies, were HIV-positive. These preliminary findings lend support to the hypothesis that antigen presentation in the lower gut may be a source of sensitization against sperm. They further suggest a possible role for antisperm antibodies as a marker of receptive anal intercourse.
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PMID:Anti-sperm antibodies in homosexual men: prevalence and correlation with sexual behaviour. 231 23

The question whether the possibility exists of transmission of HIV by hematophagous insects from infected to uninfected persons is a point of very intensive discussion. The solution of this problem could help to explain the spreading of the disease in human populations and could contribute to an understanding of the evolution of AIDS and the possible transfer from wild primates into human populations. The classical routes of pathogen transmission by blood-sucking arthropods are either "mechanical" or "biological". Both ways are rejected, the latter since no replication of the retro-virus in the vector exists and its survival in the arthropod is very limited. Based on long experimental experience with biting flies as well as with plant-sucking insects a third hitherto neglected way of transmission by regurgitation of gut content can be introduced. Since regurgitation is neither "mechanical" nor "biological", "regurgitative transmission" must be introduced as an additional term.
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PMID:[Is there the possibility of transmission of AIDS by blood-sucking insects?]. 273 98

Thirty formaldehyde-fixed, paraffin-embedded endoscopic biopsy specimens from the colon and rectum of 25 patients with acquired immunodeficiency syndrome were examined using a [35S]HIV-RNA in situ hybridization procedure. Nine of the specimens contained cells that bound significant amounts of probe. Cells were considered positive if more than 50 grains of silver (over background) per 200 micron 2 were seen over cells that did not stain with eosin. Most of the positive cells resembled macrophages, although cells with condensed nuclei resembling lymphocytes were found. No epithelial cells expressing viral RNA were detected. Formaldehyde-fixed eosinophils gave spurious signals that could be reduced with sulfhydryl modifying agents. HIV-1 may be disseminated in the lamina propria of the gut at low concentrations in some patients but may not be detectable in others. The lower gut lining may be both a portal of initial infection with HIV and a target of disseminated HIV infection.
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PMID:Detection of HIV-1 RNA in the lamina propria of patients with AIDS and gastrointestinal disease. 291 67

Investigators are now predicting that 75 to 80 per cent of the 1.5 to 2.0 million HIV-positive patients in the United States will develop AIDS. The majority of AIDS patients will experience progressive weight loss and malnutrition prior to their death. Because nutritional therapy has clearly been demonstrated to have a beneficial effect on the clinical course and immunologic status of the critically ill general population, one must not disregard the potential positive benefits of nutritional therapy in the treatment of malnourished ARC/AIDS patients. As a result of the escalating cost of ARC/AIDS medical therapy and the predicted AIDS epidemic, ARC/AIDS nutritional therapy regimens must be simple to administer and cost effective. At SFGH, we have developed specific nutritional screening criteria in an attempt to identify those patients who would most benefit from nutritional therapy. Prior to initiating therapy, we interview each patient, perform a complete physical examination, conduct a thorough nutritional assessment, evaluate their gut function, and calculate their daily caloric and protein requirements. The selection of appropriate oral, enteral, and parenteral diets is crucial in the successful management of these patients. Because all ARC/AIDS patients differ in their nutritional requirements, diet tolerance, and degree of intestinal dysfunction, there is no single nutritional therapy regimen that can be utilized in the treatment of all these patients. Therefore, we recommend special individualized oral diets combined with food supplements and enteral and parenteral diets in the treatment of ARC/AIDS patients.
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PMID:Nutritional management of patients with ARC or AIDS. 313 63

Vasoactive intestinal peptide (VIP) is a 28 amino acid-residue neurovascular and gut peptide with a number of important biological activities. Recent in vitro studies suggest an immunomodulatory (depressant) role for VIP. In the present in vivo studies, employing the Hall and Morris sheep lymphocyte traffic model, acute infusions of VIP into cannulated afferent lymphatics of popliteal lymph nodes produced prompt and marked depressions in the output of both small recirculating and blast lymphocytes into popliteal efferent lymph, with a selective effect on T4 (CD4) lymphocytes. It has been suggested that the HIV (AIDS) virus may employ VIP or VIP-like receptors on brain cells and lymphocytes for intracellular access.
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PMID:Depression of lymphocyte traffic in sheep by vasoactive intestinal peptide (VIP). 341 Apr 93

Female Aedes aegypti that were given a blood meal by enema deposited yolk in their oocytes and synthesized trypsinlike enzymes in their midgut. When females were given an enema of Aea-TMOF (Trypsin Modulating Oostatic Factor) (NH2-YDPAPPPPPP-COOH) and blood both egg development and trypsin biosynthesis were inhibited. Similar results were observed if TMOF was mixed with the blood meal and fed to female mosquitoes through a membrane. Renin inhibitor (NH2-PHPFHFFVYK-COOH) or poly proline given by enema with the blood meal did not affect egg development or trypsin biosynthesis. Feeding of TMOF analogs P1 (NH2-YDPAP-COOH) or P4 (NH2-YDPAPPPP-COOH) inhibited trypsin biosynthesis in the midgut. Injecting or giving an enema of an amidated peptide (NH2-WRPGPPPPPP-CONH2) of HIV-2 X-ORF protein also inhibited egg development and trypsin biosynthesis in the mosquito gut. When [3H]TMOF was purified by high performance liquid chromatography (HPLC) and fed with the blood meal through a membrane to female mosquitoes, [3H]TMOF outside the gut increased linearly for the first 24 h and 28% of the hormone was found outside the gut at 72 h. These results suggest that TMOF and its active analogs traverse the gut epithelial cells into the hemolymph, bind TMOF gut receptor(s) and modulate trypsin biosynthesis.
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PMID:Feeding the mosquito Aedes aegypti with TMOF and its analogs; effect on trypsin biosynthesis and egg development. 748 Aug 77

This study was performed in 77 HIV1 seropositive adult patients to characterise the IgA hyperglobulinaemia seen in the serum during the course of HIV infection. It was shown that both IgA1 and IgA2 subclass concentrations were simultaneously increased but the IgA1 increase was predominant. Secretory IgA (SIgA) concentration was significantly increased and IgA activity to gliadin, bovine serum albumin, and casein could be detected and was correlated with SIgA concentration. In contrast, IgA activity to cytomegalovirus and to tetanus toxoid did not correlate with total IgA concentration. These data suggest the presence of IgA from gut mucosal origin in the serum of these patients. Hyper IgA was inversely correlated with the CD4+ cell number. The increase of all parameters studied varied according to the total IgA concentration in the serum but was also directly related to the stage of immune deficiency in patients with hyper IgA.
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PMID:Is there IgA of gut mucosal origin in the serum of HIV1 infected patients? 751 78

Control of pandemic infection of human immunodeficiency virus type 1 (HIV-1) requires some means of developing mucosal immunity against HIV-1 because sexual transmission of the virus occurs mainly through the mucosal tissues. However, there is no evidence as yet that the secretory immunoglobulin A (IgA) antibody induced by immunization with antigens in experimental animals can neutralize HIV-1. We demonstrate here that oral immunization with a new macromolecular peptide antigen and cholera toxin (CT) induces a high titre (1:2") of gut-associated and secretory IgA antibody to HIV-1. Using three different neutralizing assays, we clearly demonstrate that this secretory IgA antibody is able to neutralize HIV-1IIIB, HIV-1SF2 and HIV-1MN. Our new approach may prove to be important in the development of a mucosal vaccine that will provide protection of mucosal surfaces against HIV-1.
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PMID:Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate. 758 51

Samples were examined by polymerase chain reaction (PCR) for the presence of the putative Kaposi's sarcoma herpes virus (KSHV). KS DNA from HIV-negative, African, endemic (EKS) samples, and epidemic HIV-positive KS (AKS), and sporadic KS (SKS) samples were tested from Tanzania and Sweden. All of the HIV KS (18 African EKS and 4 Swedish SKS) as well as the HIV-positive AIDS-related KS (16 African and 7 Swedish AKS) biopsies were shown to contain the previously described DNA sequences. KS lesions from children, females, and males in various tissues were analyzed including skin, lymph nodes, gut and oral mucosa. All forms of KS showed a single PCR product of the expected size (233 base pairs). To exclude amplification of other types of herpes virus, virus preparations of Epstein-Barr virus (EBV), herpes simplex virus, cytomegalovirus, vesicular stomatitis, and human herpes virus type 6 (HHV6) were assayed, again by PCR, using the KSHV primers. No PCR products were obtained with any of these virus strains. However, most HIV-positive and HIV-negative KS DNA samples also contained either EBV and/or HHV6 sequences. All biopsies from non-KS tissues (cells) of HIV-positive and HIV-negative individuals were consistently negative for KSHV by PCR. The observation that the same herpes virus-like DNA sequence is present in endemic and sporadic, as well as AIDS-related, Kaposi's sarcoma cases suggests a possible pathogenic association between this putative novel, herpes-like virus and KS. The herpes virus-like DNA sequences described by Y. Chang in 1994 may indeed represent a novel herpes (KSHV), etiopathologically associated with various clinical forms of Kaposi's sarcoma. Its pathogenic importance is indicated by its presence in different KS tissues with various clinical types of KS and its absence from non-KS-involved tissues. Furthermore, the presence of KSHV in KS of children suggests a nonsexual mode of transmission.
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PMID:A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma. 758 56

Norwegian immunological research in gastroenterology is well recognized internationally, and the European Medical Research Council Clinical Network for Gastroenterological Immunology is organized from Oslo. This development can be explained mainly by successful cooperation between clinical gastroenterology and laboratory-based research. A current jubilee in each of these fields may justify this review. It is now well documented that the gut is the largest antibody-producing organ. A unique molecular integration exists between the local B cells and the secretory epithelium to facilitate external transport of dimeric IgA and pentameric IgM. The mucosal immune system is subjected to T-cell regulation and significant local alterations are observed in T- and B-cell populations, and in the macrophage subsets associated with several diseases of the gut. Subsequent functional immune deviation may largely explain mucosal pathology and indicates potential targets for future immunotherapeutic measures. Observations made in the gut mucosa of HIV/AIDS patients have contributed to greater understanding of the complex cellular and molecular interactions involved in mucosal immunity.
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PMID:[Immunological research and diagnosis in gastroenterology--a review on occasion of two jubilees]. 764 86


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