Gene/Protein
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Gene/Protein
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Drug
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Target Concepts:
Gene/Protein
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Query: UMLS:C0019693 (
HIV
)
170,526
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The acceptability and use of the diaphragm and lubricant gel were assessed as part of a large randomized controlled trial to determine the effectiveness of the methods in women's
HIV
acquisition. 2,452 intervention-arm women were enrolled at five Southern African clinics and followed quarterly for 12-24 months. Acceptability and use data were collected by face-to-face interviews at Month 3 and Exit. Participants were "very comfortable" with the physical mechanics of diaphragm use throughout the trial, and approval of the gel consistency, quantity and the applicator was high. At Exit, consistent disclosure of use (
AOR
1.97, 95% CI: 1.10-3.55); an overall high diaphragm rating (
AOR
1.84, 95% CI: 1.45-2.34) and perception of partner approval (
AOR
1.75, 95% CI: 1.35-2.26) were the most significant acceptability factors independently associated with consistent use. Despite being female-initiated, disclosure of use to male partners and his perceived approval of the products were factors significantly associated with their consistent use.
...
PMID:Acceptability and use of the diaphragm and Replens lubricant gel for HIV prevention in Southern Africa. 1975 18
India has the greatest number of
HIV
infections in Asia and the third highest total number of infected persons globally. Men who have sex with men (MSM) are considered by the Government of India's National AIDS Control Organization (NACO) a "core risk group" for
HIV
in need of
HIV
prevention efforts. However there is a dearth of information on the frequency of participation in
HIV
prevention interventions and subsequent
HIV
risk and other correlates among MSM in India. Recruited through peer outreach workers, word of mouth and snowball sampling techniques, 210 MSM in Chennai completed an interviewer-administered assessment, including questions about participating in any
HIV
prevention interventions in the past year, sexual risk taking, demographics, MSM identities, and other psychosocial variables. Bivariate and multivariable logistic regression procedures were used to examine behavioral and demographic correlates with
HIV
prevention intervention participation. More than a quarter (26%) of the sample reported participating in an
HIV
prevention intervention in the year prior to study participation. Participants who reported engaging in unprotected anal sex (UAS; odds ratio [OR] = 0.28; p = 0.01) in the 3 months prior to study enrollment were less likely to have participated in an
HIV
prevention program in the past year. MSM who were older (OR = 1.04; p = 0.05), kothis (feminine acting/appearing and predominantly receptive partners in anal sex) compared to panthis (masculine appearing, predominantly insertive partners; OR = 5.52, p = 0.0004), those with higher educational attainment (OR = 1.48, p = 0.01), being "out" about having sex with other men (OR = 4.03, p = 0.0001), and MSM who reported ever having been paid in exchange for sex (OR = 2.92, p = 0.001) were more likely to have reported participation in an
HIV
prevention intervention in the preceding year. In a multivariable model, MSM reporting UAS in the prior 3 months were less likely to have participated in an
HIV
prevention intervention (
AOR
= 0.34, p = 0.04). MSM who were older (
AOR
= 1.05, p = 0.05), those with higher educational attainment (
AOR
= 1.92, p = 0.0009), and MSM who were "out" about having sex with other men (
AOR
= 2.71, p = 0.04) were more likely to have reported participating in an
HIV
prevention program. Findings suggest that exposure to
HIV
prevention interventions may be protective against engaging in UAS for some MSM in India. Understanding predictors of participation in an
HIV
prevention intervention is helpful for identifying Indian MSM who might have had no exposure to
HIV
prevention information and skills building, hence allowing researchers and prevention workers to focus efforts on individuals at greatest need.
...
PMID:HIV prevention interventions in Chennai, India: are men who have sex with men being reached? 1982 22
We examined condom attitudes, perceived vulnerability to
HIV
,
HIV
testing experiences, and sexual and substance use risk behaviors of 161 active Latino male gang members, aged 18-26 years old, living in Los Angeles, California. Gang members reported negative condom attitudes and a perceived vulnerability to
HIV
. The majority (53%) of gang members reported unprotected vaginal intercourse (UVI) in the previous 12 months. Multivariate analyses indicated that participants who engaged in the following behaviors were more likely to report UVI: had sex with someone they just met (adjusted odds ratio [
AOR
] = 3.66), received money or drugs for sex (
AOR
= 5.05), or had sex with someone who had a sexually transmitted disease (
AOR
= 4.99). Participants with a higher perceived vulnerability to
HIV
were less likely to report UVI (
AOR
= 0.82). Our findings offer implications for development of an
HIV
prevention intervention for Latino male gang members.
...
PMID:Condom attitudes, perceived vulnerability, and sexual risk behaviors of young Latino male urban street gang members: implications for HIV prevention. 1982 36
Latinos in the United States are at increased risk for
HIV
and sexually transmitted disease (STD) infection. We evaluated the efficacy of a pilot lay health adviser (LHA) intervention designed to increase condom use and
HIV
testing among Latino men. Fifteen LHAs (mean age = 35.6; range 23-60 years) from 15 Latino soccer teams were trained and worked with their teammates for 18 months. Another 15 teams served as the control group. Data were collected at baseline and at 18 months post-LHA training from a random sample of teammates from intervention and control teams. Data were collected from 222 men (mean age = 29 years) who participated in one of the 30 teams. Relative to the control condition, participants in the intervention reported more consistent condom use in the 30 days preceding follow-up (unadjusted analysis, intervention, 65.6% vs. control, 41.3%; p < .001). Participants in the intervention were more likely to report condom use (adjusted odds ratio [
AOR
] = 2.3; confidence interval [CI = 1.2-4.3) and
HIV
testing (
AOR
= 2.5; CI = 1.5-4.3). LHA interventions for Latino men that are developed in partnership with community members, rely on male-centered intrapersonal networks, and are culturally congruent can enhance preventive behaviors and may reduce
HIV infection
.
...
PMID:Outcomes from a community-based, participatory lay health adviser HIV/STD prevention intervention for recently arrived immigrant Latino men in rural North Carolina. 1982 38
To better understand access to
HIV
testing and prevention services experienced by Latinos, we evaluated data compiled through Baltimore City Health Department
HIV
outreach efforts in 2008. Of 6,443 clients served, Latinos were more likely male, young, and less-educated than non-Latinos. A greater proportion of Latinos had never been tested for
HIV
compared to non-Latinos (63% vs. 20%, P < 0.001). Male gender (
AOR
1.58, 95% CI 1.04, 2.44), >8th grade education (
AOR
2.4, 95% CI 1.60, 3.60) were associated with accessing
HIV
testing in the past. Increasing age, identifying as gay or bisexual, history of sexually-transmitted disease, and injection drug use were also associated with reporting prior
HIV
testing.
HIV
prevention services for Latinos should expand to reach those who are younger, heterosexual, of lower educational level, and female.
...
PMID:Predictors of HIV testing among Latinos in Baltimore City. 1983 May 63
We conducted structured interviews with 200 men who have sex with men (MSM) recruited using time-space sampling from public sex environments (PSEs) in Chennai, India. Predictors of sexual risk behavior were assessed with chi2 tests and multiple logistic regression. One-third reported unprotected receptive anal sex (URAS) last time and 36% inconsistent condom use in the past month. URAS was associated with younger age, less than high school education, low income, and low
HIV
transmission knowledge (adjusted odds ratio [
AOR
] = 2.1, 2.5, 3.7 and 2.5, respectively). Inconsistent condom use was associated with less than high school education (
AOR
= 3.2) and low
HIV
transmission knowledge (
AOR
= 3.5). Multilevel
HIV
prevention strategies tailored for low socioeconomic kothis and other MSM in PSEs in Chennai should include peer interventions to increase knowledge of
HIV
transmission risks and sexually transmitted infections (STIs), and structural interventions to expand economic and educational opportunities, and accessible STI testing and treatment.
...
PMID:Determinants of sexual risk behavior among men who have sex with men accessing public sex environments in Chennai, India. 1985 41
To quantify the extent that South Carolina
HIV
/AIDS cases could have been diagnosed during a prior arrest we designed a retrospective population-based cohort study linking case reports from
HIV
/AIDS Reporting System (HARS) and the South Carolina Law Enforcement Division database. Data from individuals newly diagnosed between January 2001 and December 2005 were linked with statewide arrest records from April 1991 through November 2005. Criminal history data for this report were derived from 28 state prisons and more than 250 law enforcement agencies (jails, lockups, detention centers). Odds ratios and 95% confidence intervals were used to determine how demographic variables and arrest reasons affects receipt of
HIV
testing. There were 1961/4036 (48.6%) incident cases of
HIV
diagnosis that had at least one arrest prior to their first positive
HIV
test. When restricted to 1286/1961 (65.6%) individuals most likely to have been
HIV
-infected at the time of arrest, 592 (46%) were early testers (no AIDS within 1 year) and 694 (54%) developed AIDS more than 1 year of testing (late testers). After controlling for gender, age, race, behavioral risk and source of
HIV
report, the odds of being a late tester increased with age (p < 0.001). Overall, 3750 separate arrests were recorded for these 1286 individuals and 491 (13%) arrests were for drug and alcohol or sex crimes. Individuals with 4 or more arrests were more likely to be late testers when compared to those with fewer than 4 arrests (adjusted odds ratio [
AOR
] 3.30; 95% confidence [CI] 2.28, 4.72). Correctional facilities present considerable opportunities to identify individuals with undiagnosed
HIV infection
. Providing correctional facilities with the infrastructure for implementation of routine
HIV
testing would consequently have a significant impact on the health status of the entire community.
...
PMID:Missed opportunities for early HIV diagnosis in correctional facilities. 1990 69
Individuals with
HIV
experience fluctuating levels of distress throughout the course of
HIV infection
. This study was conducted to examine the associations of depressive symptomatology with
HIV disease
in a cohort of individuals who are engaged in routine medical care. This cross-sectional study examined the prevalence of depressive symptoms that were measured as part of a standard of care behavioral assessment among individuals at an urban
HIV
clinic in the Midwest. Demographic characteristics, depressive symptoms, and behavioral risk factors were collected. A total of 514 individuals participated in the study, the majority of whom was male and African American. One quarter of the sample endorsed symptoms of other depressive disorder, while 18% (n = 91) endorsed symptoms of major depressive disorder as measured by the Patient Health Questionnaire-9 (PHQ-9). Among those on highly active antiretroviral therapy (HAART), individuals who were unemployed (adjusted odds ratio [
AOR
] = 2.47, 95% confidence interval [CI] = 1.54, 3.97), had a minor dependent (
AOR
= 2.17, 95% CI = 1.25, 3.77), or between the ages of 18 and 34 years (
AOR
= 1.37, CI = 1.03, 1.94) and detectable
HIV
viral load (
AOR
= 2.52, 95% CI = 1.22, 5.23) were more likely to report depressive disorder symptoms when controlling for age, gender, race, and education. Nearly 15% of the sample endorsed having suicidal thoughts at least once in the past two weeks. Regardless of HAART prescription, individuals who were unemployed had a higher likelihood of expressing suicidal ideation (
AOR
= 3.43, 95% CI = 1.66, 7.06). Given the association between depressive symptomatology and poor rates of
HIV
viral suppression, screening and appropriate interventions for depressive symptoms are warranted in the
HIV
outpatient setting to improve outcomes.
...
PMID:Routine screening for depression: identifying a challenge for successful HIV care. 1992 8
We examined whether men who have sex with men (MSM) in France have adopted serosorting with their casual partners, serosorting being one strategy to reduce the risk of
HIV
transmission. We expected to see the same predictors of this practice with casual partners in France as in other similar MSM communities (
HIV
-seropositive, Internet dating). Data from a cross-sectional survey was used, based on a self-administered questionnaire conducted among readers of the gay press and users of gay websites in 2004. The study population consisted of MSM who reported their
HIV
status, as well as the practice of unprotected anal intercourse (UAI) with a casual partner at least once during the previous 12 months. Among 881 respondents included in the analysis, 195 (22%) had practiced serosorting: 14% among
HIV
-seropositive men and 26% among
HIV
-seronegative men. Serosorting was independently associated with the use of cruising venues (
AOR
0.28, p=0.001) and Internet dating (
AOR
2.16, p=0.051) among
HIV
-seropositive men, whereas it was independently associated with the use of cruising venues (
AOR
0.59, p=0.013) and the fact of having less partners (
AOR
1.50, p=0.046) among
HIV
-seronegative men. Serosorting requires an up-to-date knowledge of
HIV
serostatus for MSM and their UAI casual partners, and does not prevent from acquiring other sexually transmitted infections. Prevention campaigns are needed to underline the risks associated with serosorting.
...
PMID:Do men who have sex with men use serosorting with casual partners in France? Results of a nationwide survey (ANRS-EN17-Presse Gay 2004). 1994 5
Latinos in the United States are an ethnically diverse group disproportionately affected by
HIV
/AIDS. We describe
HIV
seroprevalence,
HIV
risk behaviors and utilization of health services among Mexican American injection drug users (IDUs) in California (n = 286) and compare them to White (n = 830) and African American (n = 314) IDUs. Study participants were recruited from syringe exchange programs (n = 24) in California.
HIV
seroprevalence among Mexican Americans (0.5%) was dramatically lower than Whites (5%) and African Americans (8%). Mexican Americans reported fewer sex-related risks than Whites and African Americans though injection-related risks remained high. Compared to Whites, Mexican Americans were more likely to participate in drug treatment during a 6 month period (
AOR
1.5, 95% CI 1.1, 2.0) but less likely to receive any health care (
AOR
0.6, 95% CI 0.5, 0.8). Exploring cultural and structural factors among Mexican American IDUs may offer new insights into how to maintain low rates of
HIV
seroprevalence and reduce barriers to health care utilization.
...
PMID:HIV risks and seroprevalence among Mexican American injection drug users in California. 2002 Jan 94
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