Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019693 (
HIV
)
170,526
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Some nutritional therapy is considered alternative or experimental, but basic good nutrition is essential to effectively combat
HIV
. The gastrointestinal tract is susceptible to a variety of opportunistic infections. Common medical problems of the gastrointestinal system are listed, and patients are advised to choose foods that give them adequate nutrients and calories to maintain their body mass.
STEP
Perspect 1996
PMID:Nutrition power not an alternative. 1136 61
HIV
treatment has become so effective that people are beginning to speak of eradicating the disease. However, patients need to become thoroughly informed about treatment options in order to ensure that they are getting the best care available. Patients generally do better if their physician is experienced in dealing with
HIV
and AIDS patients, and follows the aggressive therapy options outlined. Preventive therapy for opportunistic infections is also important. Patients are told what to expect if they choose to participate in a clinical trial.
STEP
Perspect 1996
PMID:Evaluating treatment options and health care providers: strategies for self-advocacy. 1136 63
Health care workers who deal with
HIV
patients are trained and knowledgeable in universal precautions. However, they remain at risk of seroconversion from accidental exposure, and new treatment options are highlighted. Theories on viral dynamics and aggressive antiretroviral regimens suggest that health care workers receive post exposure prophylaxis. Risk factors are identified; needlesticks, which are thought to be the most risky, result in seroconversion only 0.2 to 0.3 percent of the time.
STEP
Perspect 1996
PMID:New recommendations on health care worker exposure to HIV. 1136 68
Although the advent of protease inhibitors has greatly extended the life expectancy of those living with
HIV
, they also have introduced the problems of emotionally dealing with a chronic illness. Depression appears to be the most common psychiatric disorder found among
HIV
-infected individuals. Preliminary evidence suggests that depressive symptoms may be associated with increased mortality. Treatment options are discussed, including psychotherapy and treatment with pharmaceuticals.
STEP
Perspect 1997
PMID:Depression & HIV: assessment and treatment. 1136 69
An
HIV
-positive diagnosis is often followed by wasting syndrome, in which chronic loss of muscle makes the patient feel progressively weaker and sicker. Exercise and eating can minimize muscle loss. Patients are advised to eat small frequent meals with high calorie and high protein foods. They should also eat at least four servings of starches, two of dairy products, and three fruits and vegetables. Exercise is important, and can reverse some of the muscle loss.
STEP
Perspect 1997
PMID:Food, fitness and HIV: the connection. 1136 72
Scientists have identified a number of chemical messengers that play a fundamental role in directing the body's natural response to the invasion of organisms and pathogens in the human immune system. One group, cytokines, are an essential communications link between the cells of the immune system and the body. The decrease in immune function with
HIV
is apparent in both the amount of
HIV
detected and in the decline in CD4 cells. Levels of two cytokines, IL-12 and IL-2, appear to have a direct correlation to cellular immunity. Treatment with these two substances may strengthen immune function and decrease the pace of disease development. Recombinant forms have been developed as hopeful treatments for cancer,
HIV
, and other infectious diseases.
STEP
Perspect 1997
PMID:Immune modulation with IL-2 and IL-12. 1136 73
The economics of medical care financing have forced significant changes to care delivery in the United States, the only leading country where health care is a for-profit industry. One major change has been the rapid movement toward managed care programs, where enrollment has grown from 29 percent in 1988 to 51 percent in 1993. A limitation on health care reform has been the Employee Retirement Income Security Act (ERISA) that prohibits any significant regulation of health care at the State level. Various insurance schemes and their impact on revenues for the health providers and the implications for people being treated for
HIV
, AIDS, or related opportunistic infections are described.
STEP
Perspect 1997
PMID:The impact of managed care on people living with HIV: quality vs. cost-saving. 1136 24
The National Conference for Women and
HIV
focused on research and treatment for women living with
HIV
, the largest growing segment of infected persons in the United States. Research has traditionally underrepresented women, partly due to a restriction excluding women of childbearing age in early clinical trials. Most research that has been done with this group has been on preventing vertical transmission of
HIV
to children. Other research has emphasized testing women, rather than treating them. This conference brought together researchers, clinicians, health care providers, policy makers, and women affected by
HIV
to share information on vaccines, therapeutic agents, and behavioral interventions.
STEP
Perspect 1997
PMID:National Conference for Women and HIV: an update. 1136 26
The field of chemokine research began in 1996, and research is underway that may lead to therapies that can prevent the virus from infecting cells, thereby limiting the transmission of
HIV
. Chemokines are soluble proteins that attract white blood cells to an inflamed area and bind to a specific receptor (monocyte, lymphocyte, basophil, or eosinophil) on the surface of a white blood cell in a precise interaction. Studies of these molecules could lead to greater understanding of the mechanisms of
HIV infection
. A major question will be how chemokines and their receptors impact future treatments. They may possibly be used in a vaccine to block
HIV infection
, but a prior practical application will probably be in the development of a diagnostic test.
STEP
Perspect 1997
PMID:Chemokines: implications for HIV. 1136 27
Volunteers are being sought for free clinical trials in Washington State. Antiretroviral/immunological studies include: the effect of AZT or ddI therapies on hearing, the presence of
HIV
in spinal fluid and the genital tract, and a comparative study of hydroxyurea and ddI. Opportunistic infection studies include: comparing chronic suppressive therapy versus episodic therapy for oropharyngeal candidiasis, nitazoxanide versus placebo for cryptosporidiosis, and memantine for AIDS dementia complex. Other clinical trials will study treatments for cervical dysplasia and Kaposi's sarcoma. Contact information is provided.
STEP
Perspect 1997
PMID:University of Washington AIDS Clinical Trials Unit. List of studies - July 1997. 1136 28
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