Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019693 (HIV)
 170,526 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Food and Drug Administration (FDA) warns that the antihistamine terfenadine, found in Seldane and Seldane-D, cannot be taken with Crixivan, Norvir, Invirase, Fortovase, and Viracept. Taking terfenadine products with these anti-HIV drugs can lead to a potentially fatal heart condition. The FDA formerly suggested taking the drug off the market and replacing it with Allegra (faxofenadine hydrochloride), a safer drug.
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PMID:Seldane warnings. 1136 51

Controversy exists over whether numbers obtained from Quant. PCR & bDNA tests actually represent the HIV virus; however, a researcher is collecting evidence to determine whether both tests have the same prognostic value as the beta 2 microglobulin tests. There is enough evidence to show that beta 2 microglobulin levels correlate directly with high viral loads. The researcher speculates that Quant. PCR or bDNA measures the combined effects of both HIV and HHV-6A infection in destroying cells. To help resolve this and other issues, volunteers with Chronic Fatigue Immune Dysfunction Syndrome (CFIDS) and active HHV-6A infection are being sought. Volunteers will be asked to use Norvir after which its effectiveness against HHV-6A infection will be determined. CFIDS patients will show a viral load for HIV even though they do not have the virus; the research speculates that if the PCR test for HIV is non-detectable in HHV-6A related cases, it will prove that Quant PCR is not measuring HHV-6A titers in persons with AIDS. Other diagnostic tests are available to patients. Five of these tests are briefly summarized and responses to patient questions regarding viral load issues and therapy are included.
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PMID:Quant. PCR and bDNA - the search for the truth continues as high viral load are linked to high beta 2 microglobulin levels. 1136 17

Anti-HIV therapy research continues to show promising results and a research update is presented on the following antiviral topics: efavirenz (DMP 266, Sustiva), indinavir (Crixivan), indinavir plus ritonavir (Norvir), hard vs. soft gel saquinavir, nelfinavir (Viracept) cross-resistance, and T-20 (pentafuside). Tables present regimen results, including viral load drop and CD4 cell increases. Difficulties in preventing viral resistance are also discussed. Situations to avoid include using dosing schedules that do not sufficiently suppress the virus, waiting for viral load to return to pre-treatment levels before switching drugs, and not switching drugs to at least two new potent compounds when changing combination therapy. The challenge for patients who have failed previous drug therapies is to develop strategies that allow them to extend the effectiveness of their options long enough for at least two new potent drugs to become available.
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PMID:Update on antivirals. 1136 81

Several clinical trials are underway for both adults and children. ACTG 377 is studying four different drug combinations in pediatric patients up to 17 years of age. The drugs are 3TC (Epivir, lamivudine), d4T (Zerit, stavudine), nelfinavir (Viracept), nevirapine (Viramune), and ritonavir (Norvir). The Phase I/II study is testing for safety and efficacy. FDA 285A is studying the experimental second generation protease inhibitor ABT-378, in combination with ritonavir and 3TC or d4T. Researchers at the National Institutes of Health (NIH) are studying the effectiveness of once-daily dosing of ddI in combination with d4T, in treatment-naive people, and they are also pursuing a study to determine where HIV hides in the body. Enrollment criteria and contact information are included for each study.
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PMID:Drug studies for children and adults. 1136 82

Little research has been done on the interaction of various anti-HIV drugs and birth control pills. Contraceptive levels decrease with the introduction of some protease inhibitors such as Norvir (ritonavir) or Viracept (nelfinavir). Studies suggest that if a woman is taking both antiretroviral drugs and birth control pills she should discuss increasing the birth control dosage and/or using other means of preventing pregnancy with her doctor.
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PMID:Pregnant pause. 1136 43

Dr. Charles Flexner, an Associate Professor at Johns Hopkins University, discusses different issues involving drug interactions. Flexner states that some interactions exist between street drugs and HIV medications, including between benzodiazepines and Ritonavir (Norvir) or Nelfinavir (Viracept). He also reports on toxicity and death cases associated with MDMA (ecstasy) and protease inhibitors. Drugs for opportunistic infections are also described; most are not implicated in clinically significant drug interactions, nor are most over-the-counter medications. Dr. Flexner's opinions on protease-sparing regimens and lipodystrophy are also provided.
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PMID:Double jeopardy: the hazards of drug-drug interactions. 1136 84

Four protease inhibitors are compared: Saquinavir (Invirase, Fortovase), Indinavir (Crixivan), Ritonavir (Norvir), and Nelfinavir (Viracept). Key questions are answered on how dosages change when combined with nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and other protease inhibitors. Information on administration and storage and the impact of each drug on disease development are reviewed. Drug interactions between protease inhibitors and other HIV drugs and non-HIV medications are described. Side effects are also discussed. Pediatric use is addressed, including suggested dosages. Contact information for each manufacturer is provided, along with approximate annual price for treatment.
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PMID:Protease inhibitors at a glance.... 1136 98

Two recent reports indicate that the anti-HIV drugs Viramune (Nevirapine) and Sustiva (efavirenz) can reduce levels of Methadone, sometimes causing withdrawal. Other drugs already known to reduce Methadone levels include Norvir (Ritonavir) and Viracept (Nelfinavir), while Crixivan (Indinavir) and Fortovase (Saquinavir) may increase them. Another study has shown that Methadone may lower levels of ddI (Videx), suggesting a need to increase ddI dosages in those taking Methadone.
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PMID:Methadone and anti-HIV drugs. 1136 5

Spanish researchers have reported that people with HIV are more likely to change therapy if they begin therapy with Norvir, rather than with Saquinavir or Crixivan. Nearly half the patients who started with Norvir switched while only 25 percent of the Saquinavir patients and 22 percent of the Crixivan patients switched therapies. Reasons for switching therapies are discussed.
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PMID:Switching. 1136 44

The hybrid protocol being followed by AIDS patient Marc Correa is detailed. His regimen, based only on the use of nutritional and immune-based therapies, has reduced his viral load to undetectable levels. Information about ordering his complete current protocol is included. Improvements are also noted for patients who have taken L-methionine for insomnia and Nature?s Biotics soil-based organisms and wild oregano for yeast infections. Some physicians are now putting patients on pharmaceutical regimens with up to six drugs. Even when effective against HIV, these potent combinations can cause side effects leading to organ failure. Keep Hope Alive suggests there may be both benefit and safety in combining drugs like Norvir with Rescriptor or D4T or 3TC, and adding five or six non-toxic, immune-based and nutritional therapies. Contact information is included.
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PMID:Hybrid protocols. 1136 46


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