Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019693 (HIV)
 170,526 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the Institute of Venereology, 5351 patients (75.1% of males, 24.9% females), intravenous drug users (IVDU), have been tested for the presence of HIV antibodies in the period from Jan 1986 to Dec 31 1989. They were patients of detoxication wards and/or pensioners of drug treatment centers. HIV antibodies were determined by the EIA method (Abbott Recombinant HIV-1 EIA test), and positive results were confirmed by the western-blot technique. HIV antibodies were found in 292 patients: 228 males (78.1%) and 64 females (21.9%), which accounts for 5.5% of tested IVDU. In 1986-1987 all tests were negative, although the first HIV infection was confirmed in 1985 in homosexual group. The first positive HIV test in drug addicts was detected in Aug 1988 after testing of 2254 patients. In 1989 276 sera were positive for HIV antibodies (11.2%) among 2471 patients studied. Our study indicates that HIV infection is spreading rapidly in IVDU population. Infections of drug addicts with HIV represent 66% of total detected cases of HIV antibody-positive individuals in Poland; among 30 diagnosed AIDS cases 5 were drug users.
 ...
PMID:[Rapid spread of HIV infections among narcotic addicts]. 224 14

We report a series of seven patients with reactive hemophagocytic syndrome, which was quite characteristic of its etiological spectrum. Infections were the leading cause, among them a case associated with HIV and another one with Salmonella enteritidis (a hitherto unreported association). The clinical findings consisted of fever, hepatomegaly, splenomegaly, lymphadenopathy, rash and pancytopenia. The diagnosis was carried out by bone marrow aspiration-biopsy except in two patients who were diagnosed at autopsy. The difficulty of the differentiation from malignant histiocytosis is discussed: one case of hemophagocytic syndrome due to diphenylhydantoin toxicity (the second reported one in the literature) was histologically undistinguishable from it. We think that, in any etiology, hemophagocytic syndrome is a reactive syndrome with variable intensity. The need for extensive microbiological investigation even in cases of histiocytosis of neoplastic appearance is emphasized.
 ...
PMID:[Reactive hemophagocytic syndrome: analysis of a series of 7 cases]. 232 64

Pulmonary infections are the most important life-threatening complications in HIV disease. Pneumocystis carinii pneumonia being most frequent often presents with atypical radiologic features. Infections by mycobacteria and pyogenic bacteria are of growing importance. Due to the nonspecific clinical and radiological presentation and the numerous coinfections an appropriate workup with emphasis on bronchioalveolar lavage and blood cultures is essential.
 ...
PMID:[Lung infection in HIV disease]. 234 25

Infections caused by herpes simplex virus (HSV) are a significant source of morbidity in immunocompromised patients. Acyclovir is often used prophylactically and therapeutically in patients with human immunodeficiency virus infection. The emergence of acyclovir-resistant strains of HSV capable of causing disease has been recognized. We report a case in which a thymidine kinase-deficient mutant of HSV caused extensive disease in a patient with AIDS. This case emphasizes that virus recovered from nonhealing lesions should be submitted for further study, which may advance our understanding of the interaction between host defense and drug-resistant strains.
 ...
PMID:Mucocutaneous dissemination of acyclovir-resistant herpes simplex virus in a patient with AIDS. 254 44

To characterize the host range of different strains of HIV-1, we have used four types of cells, primary monocyte-derived macrophages (MDM), primary PBL, a promonocyte cell line (U937), and a CD4+ T cell line (SUP-T1). These cells were infected with three prototype strains of HIV-1, a putative lymphocyte-tropic strain (IIIB), and two putative monocyte-tropic strains (SF162 and DV). Infections were monitored by assays for infectious virus, for cell-free and cell-associated viral antigen (p24), and for the proportion of cells infected by immunohistochemical staining. It was concluded that: (a) the use of four different cell types provides a useful biological matrix for distinguishing the tropism of different strains of HIV-1; this matrix yields more information than the infection of any single cell type. (b) A monocyte-tropic strain of HIV-1, such as strain SF162, shows a reciprocal host range when compared with a lymphocyte-tropic strain such as IIIB; strain SF162 replicates well in primary MDM but not in U937 or SUP-T1 cells, while strain IIIB replicates well in both U937 and SUP-T1 cells but not in MDM. (c) Both lymphocyte-tropic and monocyte-tropic strains of HIV-1 replicate well in PBL. (d) The promonocyte cell line, U937, and the T cell line, SUP-T1, differ markedly from primary cells, such as MDM and PBL, in their ability to support the replication of different strains of HIV-1; these cell lines cannot be used as surrogates for primary cells in host range studies of HIV-1 strains.
 ...
PMID:Infection of monocyte-derived macrophages with human immunodeficiency virus type 1 (HIV-1). Monocyte-tropic and lymphocyte-tropic strains of HIV-1 show distinctive patterns of replication in a panel of cell types. 257 66

Acquired immunodeficiency syndrome (AIDS) was first noticed in 1981 by Centers for Disease Control (CDC). Since then, the number of patients has continued to increase and reached 151,790 by the end of April 1989. AIDS is caused by the infection of Human Immunodeficiency Virus (HIV), which infects CD4+ cells including helper-inducer T-cells. The infection with HIV thus induces severe impairment of the immune mechanism, especially of cellular immunity, of the infected host, and, as a result, various types of opportunistic infections and special types of tumors could occur. Infections with mycobacteria may, of course, complicate to the AIDS patients as one of such infections. In this articles I tried to summarize the literatures on mycobacterial infections in AIDS patients and on the influences of AIDS on the tuberculosis programme. Such knowledge, will be indispensable for the specialists in tuberculosis and pulmonary diseases in near future.
 ...
PMID:[AIDS and mycobacterial infection]. 268 15

Infections caused by mycobacteria other than Mycobacterium tuberculosis (MOTT) have often been described as common in AIDS patients. To evaluate whether infections with MOTT are specific for HIV related immunosuppression or are also frequent in patients with immunosuppression of different aetiology, data on the frequency of isolation from immunosuppressed patients with HIV infection are important. Blood, stool and urine specimens from 134 patients with non-HIV related immunosuppression, and from 55 immunocompetent subjects were examined for mycobacteria. MOTT have been isolated from one immunocompetent person but from none of the immunosuppressed patients. Since in AIDS patients an initial colonization of the gastrointestinal tract (GI-tract) with MOTT is common, GI-tract biopsy specimens from an additional 80 patients were examined microscopically and histologically for mycobacteria. Mycobacteria were not isolated from these specimens. In the same period of time 72 AIDS patients have been examined; 7 (10%) had infections with M. tuberculosis whereas MOTT have been isolated from 16 (22%) of these patients. Mycobacteria have been found only rarely in immunocompetent patients and have not been isolated from patients with non-HIV related immunosuppression. The isolation of MOTT is highly correlated with an HIV-related immunosuppression.
 ...
PMID:Immunosuppression and mycobacteria other than Mycobacterium tuberculosis: results from patients with and without HIV infection. 280 16

Human immunodeficiency virus type 1 (HIV-1) can infect CD4+ lymphocytes, monocytes-macrophages, and various other cell lines, including B-cell lines. To study the parameters of B-cell infections, we examined the susceptibility of 24 B-lymphoid cell lines to both HIV-1 and HIV-2 infections. These cell lines included a series of Epstein-Barr virus (EBV) genome-negative Burkitt's lymphoma cell lines and their EBV-converted counterparts. To infect these cells we used two HIV-1 isolates and one HIV-2 isolate. Infections were monitored with a cytoplasmic RNA dot-blot and a syncytium assay. HIV infection was also studied by a novel method based on electrophoresis of DNA liberated from cells that were lysed in situ in the well of an agarose gel. All human B-cell lines could be infected with HIV-1, regardless of the presence of EBV genomes; thus, EBV infection had no major effect on HIV susceptibility of B-cell lines. Integrated proviral HIV genomes could be detected by Southern blot analysis of DNA extracted from long-term, non-HIV-producing B-cell lines. This study suggests that B-lymphoid cells may serve as reservoirs for latent or persistent HIV infections in vivo, even in the absence of EBV infection.
 ...
PMID:Epstein-Barr virus-positive and -negative B-cell lines can be infected with human immunodeficiency virus types 1 and 2. 284 99

HIV is a retrovirus. Infection with HIV results in a progressive loss of immune function, primarily of the T-helper lymphocyte, although other arms of the immune system are secondarily affected. Patients who develop AIDS are amazingly susceptible to the development of opportunistic infections and neoplastic diseases. Common presentations include pneumonia, gastrointestinal infections, and central nervous system infections. Infections are usually due to reactivation of latent infections. These infections have a tendency to relapse and prolonged treatment appears to be necessary. HIV infection is occurring worldwide and medical personnel, especially pulmonary physicians, will be increasingly required to diagnose and treat infections occurring in these patients. The spread of HIV infection is already altering the epidemiology and clinical presentation of major infectious illnesses such as syphilis and tuberculosis.
 ...
PMID:Overview of infection with the human immunodeficiency virus: infectious complications. 284 9

Bacterial pneumonias occur with increased frequency and can be associated with increased morbidity in the HIV-infected population compared with normals. The pathogens that most frequently cause community-acquired pneumonias are S. pneumoniae, H. influenzae, and occasionally S. aureus. These pneumonias usually respond to appropriate antibiotic therapy; however, patients diagnosed with bacterial pneumonias are at increased risk for subsequent episodes. Nosocomial pneumonias, by contrast, are usually caused by gram-negative organisms and have a high mortality. Fungal pneumonias also have an increased incidence in AIDS patients, and usually occur in the setting of disseminated disease. Infections caused by C. neoformans, H. capsulatum, and C. immitis often recur despite a good initial response to amphotericin B. Maintenance therapy with an antifungal agent is therefore recommended.
 ...
PMID:Bacterial and fungal pneumonias. 304 80


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>