Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019693 (HIV)
 170,526 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

ACT UP, charging Kaiser Permanente with substandard treatment of people with AIDS, has presented the company with a list of demands. The demands include faster patient access to their own doctors and to specialists, lengthening patient hospital stays when appropriate, offering viral testing to HIV-positive individuals, paying for human growth hormone to treat wasting syndrome, allowing patients to quickly switch doctors, and helping more patients enroll in clinical trials outside the Kaiser system. The San Francisco AIDS Foundation also signed the protest and urged Kaiser to reevaluate its policy on offering primary prophylaxis for CMV disease and MAC to people with AIDS who have low CD4 T-cell counts. Kaiser responds that it gives its HIV-infected patients world-class care.
 ...
PMID:World class care at Kaiser? 1136 14

Thalidomide (Synovir), noted for causing severe birth defects when taken by pregnant women, can effectively and safely heal serious mouth ulcers (oral aphthous ulcers) in people with HIV infection. Interim results from a study supported by the National Institute of Allergy and Infectious Diseases (NIAID) show that ulcers healed in 14 of 23 people taking 200 mg/day oral thalidomide compared to only 1 of 22 people receiving placebo. Celgene Corporation is conducting a multicenter, double-blinded, placebo-controlled study of Synovir for the treatment of wasting syndrome. Participants will receive the drug for free, and will take one of three doses: 10, 50, or 200 mg. Interested parties should call the Healing Alternatives Foundation or the PWA Health group.
 ...
PMID:Thalidomide for mouth ulcers and wasting. 1136 16

Exercise is important for HIV-positive people, but what type of exercise to use is still under debate in the scientific community. Scientific studies found that aerobic exercise increases CD4 counts. Scientists recommend aerobics at any stage of HIV infection. Start at an easy intensity level and do not disrupt the routine; stopping can suppress the immune system. Intensive exercise can also be immunosuppressive. Some cases of AIDS-wasting syndrome have been reversed using weight training and vitamins, antioxidants, or anabolic steroids. Some trainers believe that all cases of wasting can be reversed by this regime, as long as diarrhea is controlled and fever is not present. Aerobic exercise can actually be detrimental to HIV-positive patients because it increases the stress hormone, cortisol, which destroys muscle mass. Stretching exercises, such as yoga and tai chi, can reduce levels of cortisol. Another personal trainer advocates the use of anabolic steroids for HIV-positive people. Injectable steroids used with exercise work best, but exercise alone can also be beneficial for fighting depression, AIDS-related wasting, and high blood pressure. An unpublished scientific study found a temporary drop in neutrophils and monocytes, two kinds of white blood cells, after aerobic exercise. These scientists still recommend moderate exercise done at an individual pace.
 ...
PMID:Don't just sit there. 1136 19

Johns Hopkins University is conducting two studies on the effectiveness of testosterone for AIDS-related wasting syndrome in men. In one study, the male hormone or a placebo will be injected into HIV-positive men. In another study, participants will receive testosterone through a skin patch placed on the scrotum.
 ...
PMID:New studies on testosterone and wasting. 1136 32

In October 1992, [name removed], an aluminum siding installer, applied for Supplemental Security Income Insurance Benefits and Disability Insurance Benefits because he was no longer able to perform construction jobs. His claims were denied. [Name removed] is a former alcohol, tobacco, and drug abuser who also contracted HIV and hepatitis C. [Name removed]'s physician diagnosed chronic obstructive pulmonary disease, emphysema, AIDS wasting syndrome, and alcoholism-induced peripheral neuropathy. U.S. District Judge Robert P. Patterson Jr. ruled that [name removed] was not incapacitated and should find a sedentary job. The judge did not take into account the wasting syndrome or the peripheral neuropathy. Rather than appealing the decision, Mr. [Name removed] will reapply based on new medical information that shows his condition has worsened since the original application.
 ...
PMID:Disability claim rejected despite AIDS condition. 1136 70

Manhattan Criminal Court Judge Robert M. Stolz has refused to dismiss charges of marijuana possession and distribution against [name removed] was arrested for selling marijuana to a man with AIDS in a New York City park. [Name removed] claims that he sold marijuana at cost to HIV/AIDS patients with wasting syndrome. [Name removed]'s argument that his actions are justifiable on humanitarian grounds will be decided by a jury. Judge Stolz noted that the therapeutic administration of marijuana demands medical supervision and that [name removed]'s actions were indistinguishable from those of illegal drug dealers.
 ...
PMID:Judge refuses to sanction medicinal marijuana. 1136 73

The Food and Drug Administration's (FDA) Antiviral Drugs Advisory Committee met February 27 to March 1, 1996. At the meeting, the FDA granted full approval of ritonavir for the treatment of advanced AIDS. Ritonavir manufacturer, Abbott Laboratories, characterized the drug as generally well-tolerated, with the most common side effects being nausea, vomiting, and diarrhea. The committee also recommended accelerated approval of Merck's protease inhibitor, indinavir. Results of several clinical studies and protocols are presented. The committee voted against somatropin (Serostim), the recombinant human growth hormone, for treatment of AIDS-related wasting syndrome. They cited too many gaps in the research data. The manufacturer, Serono, is currently negotiating with the FDA on the best way to pursue approval. The committee also unanimously recommended that ddI (Videx) be indicated as a first-line treatment for HIV. The drug appears to be superior to AZT in delaying disease progression and death.
 ...
PMID:Highlights from the FDA antiviral drug advisory committee meetings, February 27-March 1, 1996. 1136 21

Controversy exists about the use of a new oral testosterone treatment, oxandralone (Oxandrin), manufactured by Bio-Technology General of Iselin, NJ. The drug was approved through the Food and Drug Administration's investigational new drugs (IND) procedure for promoting weight gain in HIV-positive individuals. Oxandralone, approved in the 1960s for disorders affecting growth in children, has been shown to have more anabolic activity and fewer masculinizing effects than other testosterone drugs, according to the company literature. However, experts in wasting syndrome are not prescribing the drug for their patients until larger efficacy studies are conducted. Some experts are prescribing the drug for patients identified with low levels of testosterone--research shows that about 20 percent of HIV-positive men have low testosterone levels. Kaposi's sarcoma (KS) may be an adverse effect of the testosterone supplement. Several case reports show that high doses of testosterone can suppress the biological mechanisms that help control KS lesions. Currently, the most effective treatment for wasting is human growth hormone therapy. However, the cost of the treatment, $1,000 per week, is too high for many. Two other drugs approved for the treatment of wasting are Marinol and Megace. In addition, progressive resistance exercise is effective in HIV-positive patients, even with advanced HIV disease and AIDS.
 ...
PMID:Experts leery of new oral testosterone treatment. 1136 43

Wasting syndrome, one of the most common complications of HIV disease, is more often found in people of low socioeconomic status and women. The pathophysiology of wasting and its treatment are discussed. Perturbations of metabolism, malnutrition, androgen deficiency, treating underlying illnesses, nutritional considerations, and pharmacologic approaches are explored. The first step to treating HIV wasting syndrome is to provide appropriate antiretroviral therapy, including meticulous prophylaxis and treatment of opportunistic infections (OIs). Other treatments include using oral supplements or total parenteral feeding to maintain nutritional levels, approved appetite stimulants, such as Megestrol acetate and dronabinol, or the controversial use of anabolic steroids. Concerns about steroid use include potential for abuse, and the possibility of developing malignancies and severe gonadal dysfunction.
 ...
PMID:The HIV wasting syndrome. 1136 90

An HIV-positive diagnosis is often followed by wasting syndrome, in which chronic loss of muscle makes the patient feel progressively weaker and sicker. Exercise and eating can minimize muscle loss. Patients are advised to eat small frequent meals with high calorie and high protein foods. They should also eat at least four servings of starches, two of dairy products, and three fruits and vegetables. Exercise is important, and can reverse some of the muscle loss.
 ...
PMID:Food, fitness and HIV: the connection. 1136 72


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>