Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Query: UMLS:C0019625 (
Rosai-Dorfman disease
)
763
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Sinus histiocytosis with massive lymphadenopathy
(
Rosai-Dorfman disease
) is a rare, benign self-limiting condition of unknown etiology. Less than a quarter of cases have only extranodal involvement and a few cases of skeletal involvement of
Rosai-Dorfman disease
without associated lymphadenopathy have been reported in the literature. We herein report cytohistologic findings in a case of sole skeletal
Rosai-Dorfman disease
in a 51-year-old woman who presented with an expansile, heterogeneous lesion at
T11
with cord compression and edema. A CT-guided fine-needle aspiration of T-11 lesion was performed and the sample was processed by ThinPrep technique. The ThinPrep smear showed characteristic features of
Rosai-Dorfman disease
including hypercellularity with moderate number of histiocytes in a background of lymphocytes, plasma cells, and neutrophils. The histiocytes possessed abundant, pale and vacuolated cytoplasm, rounded nuclei with smooth nuclear membranes, fine chromatin, and distinct nucleoli. The histiocytes showed emperipolesis of lymphocytes and neutrophils. The diagnosis was confirmed by concurrent biopsy with immunhistochemical study. Our case highlighted the role of fine-needle aspiration with ThinPrep technique in the diagnosis of
Rosai-Dorfman disease
.
...
PMID:Fine-needle aspiration cytology of Rosai-Dorfman disease of bone. 1852 89
