Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019625 (Rosai-Dorfman disease)
 763 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rosai-Dorfman disease (RDD) with spinal cord involvement is a rare clinical entity. We report a case of RDD with paravertebral and intraspinal epidural involvement in a 24-year-old male Bangladeshi patient who presented with progressive bilateral lower limb weakness for 20 days duration associated with spasticity and muscle spasm. MRI demonstrated an enhancing paravertebral soft tissue lesion extending from C7 through T4 with intraspinal epidural extension encasing the spinal cord with focal cord oedema. Histopathology of the paraspinal-epidural lesion reported a finding consistent with RDD. The patient was initiated on high-dose steroids. Follow up after 2 months demonstrated symptomatic improvement as the patient was able to move on the crutch and repeated MRI showed lesion regression.
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PMID:Rosai-Dorfman disease with paravertebral and epidural thoracic spine involvement: A case report and literature review. 3214 Jan 92