Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019625 (Rosai-Dorfman disease)
 763 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 47 year old Chinese man with diabetes mellitus and previously treated pulmonary tuberculosis presented with painless right testicular enlargement of 1 month's duration. He underwent an orchidectomy for presumed testicular neoplasm corroborated clinicoradiologically. Histological examination of the testicular mass revealed an inflammatory lesion comprising lymphocytes, plasma cells and sheets of pale staining histiocytes, some containing lymphocytes within their ample cytoplasm, suggestive of emperipolesis. S100 immunohistochemistry stained the histiocytes, while ultrastructural examination confirmed emperipolesis. A diagnosis of Rosai-Dorfman disease was made, an exceedingly rare testicular lesion. Clinicoradiological findings mimicked a neoplasm, while the inflammatory histological appearances with occasionally discerned multinucleated cells raised the possibility of xanthogranulomatous orchitis. Tuberculous orchitis was excluded through negative Ziehl-Neelsen stains and PCR for mycobacterium, while seminoma, which sometimes features a predominant inflammatory component obscuring neoplastic cells, was excluded by absent immunostaining for placental alkaline phosphatase and CD117.
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PMID:Rosai-Dorfman disease of the testis: an unusual entity that mimics testicular malignancy. 1650 87

A 36-year-old female presented with pain and progressive decrease in the range of movements in the left elbow. There was contact with an open case of pulmonary tuberculosis. There were no constitutional symptoms except fever. X-ray showed periarticular osteopenia with destruction of the radial neck and head. MRI scan findings were also consistent with tuberculosis of the elbow. Histopathology examination confirmed the diagnosis of Rosai-Dorfman disease. The patient was treated with glucocorticoid and methotrexate and was asymptomatic after 18 months.
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PMID:Primary Rosai-Dorfman Disease of the Proximal Radius Masquerading as Tuberculosis of Elbow. 3248 8