Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019621 (Langerhans cell histiocytosis)
3,250 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
CD1a 338
Sep 216
BRAF 175
CD68 121
S100 120
MRI 97
She 88
Langerin 88
lymphoid 57
MAP2K1 41
cytokine 38
thymus 38
lysozyme 36
MAPK 35
CD1 35
MEK 33
FDG 31
ERK 31
HLA-DR 31
CD4 29
rhabdomyosarcoma 24
Pol 23
interferon 23
CD34 22
collagen 21
vasopressin 21
RAF 21
HLA 20
nodal 20
osteosarcoma 19
reserved 17
Mol 17
CD14 17
non-Hodgkin's lymphoma 16
panhypopituitarism 16
growth hormone 16
lectin 15
factor XIIIa 15
CD163 14
NRAS 13
extracellular signal-regulated kinase 13
CD8 13
Ki-67 12
IL-1 11
vimentin 11
Mal 11
p53 11
CD11c 11
IL-17 11
KRAS 10
ARAF 10
PHA 10
esterase 9
peroxidase 9
alkaline phosphatase 9
MAC 9
insulin 9
E-cadherin 9
ALL 8
TNF 8
CD2 8
CD11b 8
macrophage colony-stimulating factor 8
hairy 8
acid phosphatase 8
IFN 8
neurofibromatosis 8
CD31 7
fascin 7
CD20 7
tumor necrosis factor 7
lacrimal 7
androgen receptor 7
X-linked 7
proto-oncogene 7
CD56 7
PI3K 7
CD30 7
PIK3CA 7
CSF 7
more...
Disease
Langerhans cell histiocytosis 3250
tumor 371
cancer 313
diabetes insipidus 261
Erdheim-Chester disease 206
Letterer-Siwe disease 205
rare disease 153
sarcoidosis 126
xanthogranuloma 113
lymphoma 112
lymphadenopathy 104
Hodgkin's disease 80
Rosai-Dorfman disease 74
leukemia 74
interstitial lung disease 70
lung disease 68
pneumothorax 66
interstitial pneumonia 64
sarcoma 62
carcinoma 60
Juvenile xanthogranuloma 58
systemic disease 57
bronchiolitis 53
metastases 51
lymphangioleiomyomatosis 50
rash 50
idiopathic pulmonary fibrosis 50
emphysema 49
xanthoma 48
tuberculosis 48
pneumonia 47
neuroblastoma 40
Hand-Schuller-Christian disease 36
respiratory failure 33
pulmonary fibrosis 33
acute lymphoblastic leukemia 32
melanoma 32
Ewing's sarcoma 31
dysplasia 31
cholangitis 30
anemia 29
hypersensitivity pneumonitis 28
immunodeficiency 28
proptosis 27
acute myeloid leukemia 27
hemophagocytic lymphohistiocytosis 27
multiple myeloma 25
osteomyelitis 25
hypothyroidism 25
rhabdomyosarcoma 24
Hashimoto's thyroiditis 24
hemangioma 23
chronic obstructive pulmonary disease 23
pulmonary hypertension 23
osteosarcoma 23
histiocytoma 22
goiter 22
Langerhans cell sarcoma 21
Pulmonary Langerhans cell histiocytosis 21
liver disease 20
thrombocytopenia 20
non-Hodgkin's lymphoma 20
craniopharyngioma 19
amyloidosis 18
bronchiectasis 18
reticulohistiocytoma 17
lung cancer 17
seborrheic dermatitis 17
panhypopituitarism 17
rheumatoid arthritis 17
osteosclerosis 17
eosinophilia 17
Epstein 17
bone disease 16
chondrosarcoma 16
virus infection 15
otitis externa 15
diabetes 15
adenocarcinoma 15
hypopituitarism 14
more...
Symptom
pain 91
dyspnea 51
cough 49
polydipsia 41
headache 41
polyuria 38
hepatosplenomegaly 33
bone pain 24
seizures 19
ataxia 17
splenomegaly 17
hepatomegaly 17
diarrhea 14
weakness 13
respiratory distress 13
chest pain 12
anesthesia 12
erythema 11
back pain 11
abdominal pain 10
vomiting 10
fatigue 9
paraparesis 8
collapse 8
exertional dyspnea 8
ENT 7
tinnitus 7
vertigo 7
dysarthria 6
torticollis 6
Ill 6
knee pain 6
otalgia 6
neck pain 5
anorexia 5
nausea 5
hip pain 4
asthenia 4
dizziness 4
paresis 4
chills 4
cerebellar ataxia 4
non-productive cough 3
pallor 3
Darier's sign 3
hemoptysis 3
paresthesia 3
dental pain 3
tachypnea 3
generalized rash 3
tremor 3
fever of unknown origin 3
night sweats 3
chronic cough 3
numbness 3
lethargy 2
shortness of breath 2
leg pain 2
hoarseness 2
pleuritic chest pain 2
low back pain 2
constipation 2
arm weakness 2
stridor 2
ophthalmoplegia 2
penile lesion 2
halitosis 2
periorbital edema 2
productive cough 2
memory loss 2
orofacial pain 2
sciatica 2
nasal congestion 2
cachexia 2
dystonia 2
General symptoms 2
shoulder pain 2
snoring 1
Welt 1
apathy 1
more...
Drug
Dermatol 267
CSF 12
Etoposide 11
-deoxyadenosine 9
DDAVP 7
DDAVP 7
Cardiovasc 6
ENT 6
Paraffin 4
Velban 4
Leaf 4
Prednisone 4
IL-2 3
Prednisolone 3
NAG 2
SMP 2
Zoledronic acid 2
IFN-gamma 2
Zoledronic acid 2
Infliximab 1
Spiriva 1
Denosumab 1
Campath 1
AraC 1
Campath 1
MDS 1
Magnevist 1
Lenalidomide 1
ADM 1
ACT 1
Dial 1
Fluconazole 1
MAP 1
Teniposide 1
CIA 1
HCG 1
Adriamycin 1
CCL 1
Methotrexat 1
Methylprednisolone 1
Monit 1
Mutagen 1
Infliximab 1
TRM 1
Itraconazole 1
Imatinib 1
G-CSF 1
Secretin 1
Fluorescein 1
Frontal 1
Amifostine 1
ARA-C 1
HCH 1
Asthma 1
CAM 1
Indomethacin 1
lactose 1
Enzyme
mitogen-activated protein kinase 72
ERK 47
lysozyme 37
MEK 36
peroxidase 13
alkaline phosphatase 9
acid phosphatase 8
focal adhesion kinase 7
transglutaminase 6
protein kinase 6
MDP 6
ATPase 4
alpha-mannosidase 4
trypsin 4
tryptase 4
SMP 4
alanine aminotransferase 4
BAL 4
phosphodiesterase 3
protein kinase C 3
BMT 3
reverse transcriptase 3
lactate dehydrogenase 3
topoisomerase 2
cathepsin K 2
PGM 2
aspartate aminotransferase 2
chymotrypsin 2
topoisomerase 2
gamma-glutamyl transpeptidase 2
AST 1
phosphatidylinositol 3-kinase 1
STK11 1
CD13 1
CD10 1
RNA polymerase 1
MIP 1
adenosine deaminase 1
ACE 1
proteasome 1
phosphoglycerate kinase 1
catalase 1
catechol 1,2-dioxygenase 1
ADH 1
neuraminidase 1
cathepsin D 1
MMP 1
CPT 1
ACS 1
phosphoinositide 3-kinase 1
alpha-galactosidase 1
urokinase-type plasminogen activator 1
TdT 1
glutathione peroxidase 1
PARP 1
phospholipase C 1
collagenase 1
prostaglandin synthetase 1
acetyl-CoA carboxylase 1
cdc2 1
alcohol dehydrogenase 1
CPT 1
MAP 1
CPT 1
beta-glucuronidase 1
adenosine deaminase 1
luciferase 1
creatine kinase 1
cathepsin B 1
MEKK1 1
botulinum neurotoxin 1
lipase 1
granzyme B 1
cellulase 1
Compound
Clin 290
Dec 206
DNA 54
MEK 32
His 23
leucine 21
VP-16 21
water 21
nitrogen 15
oxygen 15
methane 14
glucose 13
galactose 12
sodium 11
Thyroid 11
A 3 11
iron 9
acetate 9
Vinblastine 8
fluorine 8
TNF 8
CO2 8
Optimal 7
A 42 6
Prednisone 6
TSH 5
formaldehyde 5
potassium 5
ethanol 5
Letter 5
Neo 5
DTPA 5
calcium 4
BAL 4
ACTH 4
DBA 4
DBA 4
Belt 4
urea 4
hydrogen 4
nitric oxide 4
PNA 4
Cardiol 4
PAS 4
CDA 4
6-12 4
DBA 4
zinc 4
TRH 3
formaldehyde 3
sulfate 3
Ara-C 3
prostacyclin 3
arginine 3
Ara-C 3
retinoic acid 3
acetic acid 3
creatinine 3
Prednisolone 3
iodine 3
L-DOPA 2
BCG 2
Hematoxylin 2
MTX 2
hydroxide 2
N-acetyl-D-glucosamine 2
Thyroxine 2
PEA 2
Methotrexate 2
A 1 2
serine 2
glutamic acid 2
valine 2
carbonate 2
cAMP 2
Coronal 2
barium 2
GalNAc 2
PGE2 2
TBI 2
more...