Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019621 (Langerhans cell histiocytosis)
 3,250 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
CD1a 338
Sep 216
BRAF 175
CD68 121
S100 120
MRI 97
She 88
Langerin 88
lymphoid 57
MAP2K1 41
thymus 38
cytokine 38
lysozyme 36
CD1 35
MAPK 35
MEK 33
ERK 31
FDG 31
HLA-DR 31
CD4 29
rhabdomyosarcoma 24
Pol 23
interferon 23
CD34 22
RAF 21
vasopressin 21
collagen 21
nodal 20
HLA 20
osteosarcoma 19
reserved 17
CD14 17
Mol 17
growth hormone 16
panhypopituitarism 16
non-Hodgkin's lymphoma 16
factor XIIIa 15
lectin 15
CD163 14
extracellular signal-regulated kinase 13
NRAS 13
CD8 13
Ki-67 12
vimentin 11
Mal 11
CD11c 11
IL-1 11
IL-17 11
p53 11
KRAS 10
PHA 10
ARAF 10
esterase 9
E-cadherin 9
insulin 9
peroxidase 9
MAC 9
alkaline phosphatase 9
CD11b 8
CD2 8
TNF 8
acid phosphatase 8
macrophage colony-stimulating factor 8
ALL 8
neurofibromatosis 8
hairy 8
IFN 8
GM-CSF 7
CSF 7
tumor necrosis factor 7
interferon alpha 7
fascin 7
PI3K 7
X-linked 7
androgen receptor 7
CD31 7
CD25 7
PIK3CA 7
CD20 7
CD30 7
proto-oncogene 7
CD56 7
lacrimal 7
IL-1 beta 6
interferon-gamma 6
antichymotrypsin 6
alpha-fetoprotein 6
p16 6
mucin 6
p21 6
keratin 6
hemoglobin 6
IL-4 6
granulocyte-macrophage colony-stimulating factor 6
X-linked recessive 6
IL-6 6
AML 6
CD1A 6
ENT 6
MDP 6
LDH 6
cyclin D1 6
bone) 6
CD45 5
alpha 1-antitrypsin 5
arginine vasopressin 5
mast cell 5
C-reactive protein 5
severe combined immunodeficiency 5
Hop 5
ICAM-1 5
human leukocyte antigen 5
p38 5
proliferating cell nuclear antigen 5
CD15 5
CD1c 5
phosphatase 5
ALK 4
MEK1 4
LFA-1 4
Bcl-2 4
IgA 4
glycoprotein 4
TGF-beta 4
AR protein 4
FOXP3 4
CD83 4
dilute 4
chemokine receptor 4
endoplasmic reticulum 4
ACTH 4
Cytokine 4
CDKN2A 4
NMR 4
SCT 4
CDA 4
BAL 4
JAK2 4
IL-8 4
CD5 4
AKT 4
CD35 4
glial fibrillary acidic protein 4
tyrosine kinase 4
MAP kinase 4
LHRH 4
CD1b 4
ferritin 4
CD86 4
HLA class I 4
IL1 4
NOTCH1 4
interferon-alpha 4
DBA 4
osteopontin 4
IL-10 4
NF1 4
scratch 4
chemokine 4
cytokeratin 3
CD21 3
PTEN 3
RIC 3
gonadotropin deficiency 3
IGF-I 3
PLS 3
leukocyte common antigen 3
PAK4 3
Ki-1 3
KIT 3
HLA-A 3
granulocyte 3
adenosine triphosphatase 3
c-kit 3
cell surface protein 3
CCR7 3
LPA 3
cage 3
fibronectin 3
FSH 3
osteoprotegerin 3
desmin 3
myeloperoxidase 3
CD23 3
membrane-bound 3
tyrosine phosphatase 3
prolactin 3
gut 3
CD40 3
FAB 3
galactosamine 3
COPD 3
MT1 3
INF 3
carcinoembryonic antigen 3
interleukin-4 3
adhesion molecule 3
CD117 3
IL-2 3
intercellular adhesion molecule-1 3
AVP 3
placental alkaline phosphatase 3
smooth muscle actin 3
alpha-1-antitrypsin 3
ERK1 3
Polymerase 3
p44 3
NHL 3
CD1a molecule 3
vitronectin 3
PLC 3
IgE 3
CHOP 3
TNF-alpha 3
COD 3
PAK2 3
EGFR 3
PML 3
CD18 3
interleukin-10 3
phosphodiesterase 3
MEKK1 3
IP1 3
GHRH 3
STAT3 3
mitogen-activated protein 3
mTOR 3
ECD 3
mast cell tryptase 3
Mot 3
interferon gamma 3
alpha-1-antichymotrypsin 2
U2AF1 2
thyroid hormone 2
Gen 2
FLT3 2
ICD 2
PD-1 2
MAP2K2 2
fibrinogen 2
cholecystokinin 2
RANK 2
cathepsin K 2
PRL 2
CRH 2
alpha-mannosidase 2
CD100 2
lamp 2
PGM 2
CIC 2
lipopolysaccharide 2
ESR 2
CRP 2
E-selectin 2
hole 2
HLA class II 2
cell surface antigen 2
BCOR 2
JAM 2
CD58 2
SAGE 2
C-type lectin 2
CD36 2
H-ras 2
platelet-derived growth factor 2
MCP-1 2
DUX4 2
ATPase 2
SHP-1 2
CCNB3 2
Fas ligand 2
natural killer cell 2
TCR 2
transmembrane protein 2
MTX 2
vascular endothelial growth factor 2
folliculin 2
RARA 2
CD19 2
JNK 2
c-fms 2
glucosamine 2
p13 2
neurofibromatosis type 1 2
cryptic 2
IL-7 2
c-myc 2
INK4a 2
HPR 2
putative tumor suppressor 2
Tumor necrosis factor alpha 2
BTR 2
IL2R 2
hormone receptor 2
zinc finger 2
chymotrypsin 2
CCL20 2
major histocompatibility complex 2
MIB 2
Pseudomonas 2
surface antigen 2
TRH 2
alpha-smooth muscle actin 2
interleukin-2 2
Raji 2
ESI 2
CD16 2
CCL22 2
all-trans 2
bcl-2 2
CD80 2
Limulus polyphemus 2
FEV 2
matrix metalloproteinase 2
CD44 2
PKC 2
serine/threonine kinase 2
IgG3 2
CD38 2
heparin-binding epidermal growth factor-like growth factor 2
more...
Disease
Langerhans cell histiocytosis 3250
tumor 371
cancer 313
diabetes insipidus 261
Erdheim-Chester disease 206
Letterer-Siwe disease 205
rare disease 153
sarcoidosis 126
xanthogranuloma 113
lymphoma 112
lymphadenopathy 104
Hodgkin's disease 80
leukemia 74
Rosai-Dorfman disease 74
interstitial lung disease 70
lung disease 68
pneumothorax 66
interstitial pneumonia 64
sarcoma 62
carcinoma 60
Juvenile xanthogranuloma 58
systemic disease 57
bronchiolitis 53
metastases 51
lymphangioleiomyomatosis 50
rash 50
idiopathic pulmonary fibrosis 50
emphysema 49
tuberculosis 48
xanthoma 48
pneumonia 47
neuroblastoma 40
Hand-Schuller-Christian disease 36
respiratory failure 33
pulmonary fibrosis 33
acute lymphoblastic leukemia 32
melanoma 32
Ewing's sarcoma 31
dysplasia 31
cholangitis 30
anemia 29
immunodeficiency 28
hypersensitivity pneumonitis 28
acute myeloid leukemia 27
hemophagocytic lymphohistiocytosis 27
proptosis 27
multiple myeloma 25
osteomyelitis 25
hypothyroidism 25
rhabdomyosarcoma 24
Hashimoto's thyroiditis 24
chronic obstructive pulmonary disease 23
osteosarcoma 23
pulmonary hypertension 23
hemangioma 23
goiter 22
histiocytoma 22
Pulmonary Langerhans cell histiocytosis 21
Langerhans cell sarcoma 21
thrombocytopenia 20
liver disease 20
non-Hodgkin's lymphoma 20
craniopharyngioma 19
amyloidosis 18
bronchiectasis 18
panhypopituitarism 17
seborrheic dermatitis 17
Epstein 17
rheumatoid arthritis 17
osteosclerosis 17
lung cancer 17
eosinophilia 17
reticulohistiocytoma 17
bone disease 16
chondrosarcoma 16
diabetes 15
adenocarcinoma 15
otitis externa 15
virus infection 15
hypopituitarism 14
germinoma 14
cirrhosis 14
graft-versus-host disease 14
acute leukemia 14
meningioma 14
mole 14
dermatitis 14
Wegener's granulomatosis 13
immune deficiency 13
mastoiditis 13
cytomegalovirus 13
otitis media 13
hypogonadism 13
osteoma 13
mastocytosis 12
infectious diseases 12
pruritus 12
hypertension 12
hematologic malignancies 12
fibrosarcoma 12
vasculitis 12
myelodysplastic syndrome 11
lymphadenitis 11
hyperprolactinemia 11
neutropenia 11
pathological fracture 11
Central diabetes insipidus 11
lupus 11
pancytopenia 11
pneumoconiosis 11
psoriasis 11
WT1 11
systemic lupus erythematosus 10
myeloproliferative disorders 10
childhood cancer 10
asthma 10
sensorineural hearing loss 10
MAC 10
meninges 10
confusion 10
squamous cell carcinoma 10
Thorax 10
fibroma 10
PHA 10
lymphoproliferative disorders 10
vascular disease 10
growth hormone deficiency 10
periodontitis 9
mycosis fungoides 9
plaque 9
osteochondroma 9
dermatofibroma 9
skin disease 9
cystic fibrosis 9
adenoma 9
neoplastic process 9
aggression 9
hepatitis 9
obesity 9
germ cell tumor 8
HIV 8
paraproteinemia 8
malignant fibrous histiocytoma 8
Pituitary 8
primitive neuroectodermal tumor 8
amenorrhea 8
primitive neuroectodermal tumor 8
plasmacytoma 8
hypogonadotropic hypogonadism 8
brain tumor 8
xanthomatosis 8
acute monocytic leukemia 8
neurofibromatosis 8
retinoblastoma 8
chondroblastoma 8
pericardial effusion 8
eczema 8
Kaposi's sarcoma 7
periodontal disease 7
autoimmune disease 7
protein-losing enteropathy 7
herpes simplex 7
osteoporosis 7
generalized disease 7
arthritis 7
hormone deficiency 7
sepsis 7
glioma 7
PDB 7
lichen planus 7
purpura 7
connective tissue disease 7
middle ear 7
chronic myelomonocytic leukemia 7
Nose 7
breast cancer 7
renal failure 7
Xanthoma disseminatum 7
thyroiditis 7
juvenile myelomonocytic leukemia 7
chronic myeloid leukemia 7
basal cell carcinoma 7
cholestasis 7
cholesteatoma 7
tumorigenesis 7
lupus 6
varicella 6
primary tumor 6
diplopia 6
urticaria 6
myasthenia gravis 6
Mycobacterium 6
multiple sclerosis 6
acute promyelocytic leukemia 6
portal hypertension 6
Granuloma 6
renal cell carcinoma 6
hairy cell leukemia 6
sepsis 6
pituitary adenoma 6
B-cell lymphoma 6
orphan disease 6
SCID 6
fungal infection 6
teratoma 6
heart disease 6
primary sclerosing cholangitis 6
chronic osteomyelitis 6
hepatocellular carcinoma 6
spinal cord compression 6
histiocytic lymphoma 6
scabies 5
urticaria pigmentosa 5
PSS 5
Contact Dermatitis 5
HMR 5
myelofibrosis 5
residual disease 5
onycholysis 5
aspergillosis 5
lichen 5
hypercalcemia 5
petechiae 5
silicosis 5
pulmonary tuberculosis 5
gammopathy 5
chronic lymphocytic leukemia 5
facial palsy 5
tooth loss 5
chronic lymphocytic leukemia 5
pulmonary alveolar proteinosis 5
pulmonary edema 5
sickle cell disease 5
fits 5
EBV infection 5
Thyroid gland 5
bronchitis 5
conductive hearing loss 5
Niemann-Pick 5
meningitis 5
syphilis 5
epiphysis 5
Pulmonary eosinophilic granuloma 5
bronchitis 5
coagulopathy 5
gastric cancer 5
SEM 5
papillary thyroid cancer 5
hemiparesis 5
lung carcinoma 5
chordoma 5
Sclerosing cholangitis 5
hemosiderosis 5
ear disease 5
Brodie 5
hepatitis C 5
acrodermatitis enteropathica 4
hyperkeratosis 4
SCT 4
scleroderma 4
child abuse 4
cerebellar syndrome 4
dysphagia 4
carcinomatosis 4
Goodpasture's syndrome 4
glaucoma 4
encephalitis 4
T-cell lymphomas 4
lipoma 4
hydrocephalus 4
Thoracic 4
myelosuppression 4
Kimura's disease 4
Multicentric reticulohistiocytosis 4
hypernatremia 4
sinusitis 4
external ear 4
liposarcoma 4
T-cell acute lymphoblastic leukemia 4
osteogenesis imperfecta 4
pancreatitis 4
liver cancer 4
bronchogenic carcinoma 4
thyroid cancer 4
osteitis 4
Spontaneous pneumothorax 4
molluscum contagiosum 4
Benign cephalic histiocytosis 4
carcinoid 4
MRT 4
leprosy 4
DBA 4
CDA 4
optic atrophy 4
Eosinophilic granuloma of bone 4
Crohn's disease 4
mastocytoma 4
fasciitis 4
Localized disease 4
solid tumor 4
chronic otitis media 4
hamartoma 4
benign tumor 4
Neoplasms 4
thalassemia 4
hypofibrinogenemia 4
thyroid nodule 4
panniculitis 4
heart failure 4
medulloblastoma 4
respiratory disease 4
nystagmus 4
mole 4
Anterior 4
myofibromatosis 4
ACD 4
inflammatory bowel disease 4
ACTH deficiency 4
secondary amenorrhea 4
bronchopneumonia 4
more...
Symptom
pain 91
dyspnea 51
cough 49
headache 41
polydipsia 41
polyuria 38
hepatosplenomegaly 33
bone pain 24
seizures 19
hepatomegaly 17
splenomegaly 17
ataxia 17
diarrhea 14
weakness 13
respiratory distress 13
chest pain 12
anesthesia 12
back pain 11
erythema 11
abdominal pain 10
vomiting 10
fatigue 9
paraparesis 8
collapse 8
exertional dyspnea 8
vertigo 7
tinnitus 7
ENT 7
otalgia 6
torticollis 6
dysarthria 6
Ill 6
knee pain 6
anorexia 5
neck pain 5
nausea 5
asthenia 4
hip pain 4
chills 4
paresis 4
dizziness 4
cerebellar ataxia 4
pallor 3
chronic cough 3
Darier's sign 3
paresthesia 3
dental pain 3
fever of unknown origin 3
tachypnea 3
tremor 3
generalized rash 3
hemoptysis 3
night sweats 3
non-productive cough 3
numbness 3
pleuritic chest pain 2
shortness of breath 2
constipation 2
stridor 2
ophthalmoplegia 2
penile lesion 2
dystonia 2
productive cough 2
memory loss 2
periorbital edema 2
halitosis 2
arm weakness 2
orofacial pain 2
hoarseness 2
sciatica 2
cachexia 2
leg pain 2
lethargy 2
low back pain 2
General symptoms 2
nasal congestion 2
shoulder pain 2
snoring 1
Welt 1
apathy 1
spasm 1
photophobia 1
growing pains 1
Gastrointestinal symptoms 1
clonus 1
cyanosis 1
thoracic back pain 1
syncope 1
intestinal bleeding 1
pelvic pain 1
dysuria 1
blurred vision 1
ankle pain 1
tonic-clonic seizure 1
arthralgia 1
facial pain 1
adipsia 1
neuralgia 1
Halo 1
analgesia 1
clumsiness 1
discomfort 1
postnasal drip 1
dry eye 1
otorrhagia 1
neck stiffness 1
overweight 1
leg edema 1
discomfort 1
Radicular pain 1
skin damage 1
hypoproteinemia 1
wheezing 1
hypothermia 1
jaw pain 1
abdominal discomfort 1
thigh pain 1
epigastric pain 1
ataxic gait 1
limb pain 1
orthopnea 1
Drug
Dermatol 267
CSF 12
Etoposide 11
-deoxyadenosine 9
DDAVP 7
DDAVP 7
Cardiovasc 6
ENT 6
Paraffin 4
Velban 4
Leaf 4
Prednisone 4
IL-2 3
Prednisolone 3
NAG 2
SMP 2
Zoledronic acid 2
IFN-gamma 2
Zoledronic acid 2
Infliximab 1
Spiriva 1
Denosumab 1
Campath 1
AraC 1
Campath 1
MDS 1
Magnevist 1
Lenalidomide 1
ADM 1
ACT 1
Dial 1
Fluconazole 1
MAP 1
Teniposide 1
CIA 1
HCG 1
Adriamycin 1
CCL 1
Methotrexat 1
Methylprednisolone 1
Monit 1
Mutagen 1
Infliximab 1
TRM 1
Itraconazole 1
Imatinib 1
G-CSF 1
Secretin 1
Fluorescein 1
Frontal 1
Amifostine 1
ARA-C 1
HCH 1
Asthma 1
CAM 1
Indomethacin 1
lactose 1
Enzyme
mitogen-activated protein kinase 72
ERK 47
lysozyme 37
MEK 36
peroxidase 13
alkaline phosphatase 9
acid phosphatase 8
focal adhesion kinase 7
transglutaminase 6
protein kinase 6
MDP 6
ATPase 4
alpha-mannosidase 4
trypsin 4
tryptase 4
SMP 4
alanine aminotransferase 4
BAL 4
phosphodiesterase 3
protein kinase C 3
BMT 3
reverse transcriptase 3
lactate dehydrogenase 3
topoisomerase 2
cathepsin K 2
PGM 2
aspartate aminotransferase 2
chymotrypsin 2
topoisomerase 2
gamma-glutamyl transpeptidase 2
AST 1
phosphatidylinositol 3-kinase 1
STK11 1
CD13 1
CD10 1
RNA polymerase 1
MIP 1
adenosine deaminase 1
ACE 1
proteasome 1
phosphoglycerate kinase 1
catalase 1
catechol 1,2-dioxygenase 1
ADH 1
neuraminidase 1
cathepsin D 1
MMP 1
CPT 1
ACS 1
phosphoinositide 3-kinase 1
alpha-galactosidase 1
urokinase-type plasminogen activator 1
TdT 1
glutathione peroxidase 1
PARP 1
phospholipase C 1
collagenase 1
prostaglandin synthetase 1
acetyl-CoA carboxylase 1
cdc2 1
alcohol dehydrogenase 1
CPT 1
MAP 1
CPT 1
beta-glucuronidase 1
adenosine deaminase 1
luciferase 1
creatine kinase 1
cathepsin B 1
MEKK1 1
botulinum neurotoxin 1
lipase 1
granzyme B 1
cellulase 1
Compound
Clin 290
Dec 206
DNA 54
MEK 32
His 23
leucine 21
water 21
VP-16 21
nitrogen 15
oxygen 15
methane 14
glucose 13
galactose 12
Thyroid 11
A 3 11
sodium 11
acetate 9
iron 9
Vinblastine 8
fluorine 8
CO2 8
TNF 8
Optimal 7
A 42 6
Prednisone 6
formaldehyde 5
ethanol 5
potassium 5
DTPA 5
Letter 5
TSH 5
Neo 5
hydrogen 4
Belt 4
ACTH 4
DBA 4
6-12 4
BAL 4
CDA 4
PNA 4
zinc 4
nitric oxide 4
calcium 4
DBA 4
Cardiol 4
PAS 4
DBA 4
urea 4
Prednisolone 3
acetic acid 3
TRH 3
formaldehyde 3
Ara-C 3
prostacyclin 3
creatinine 3
Ara-C 3
sulfate 3
arginine 3
iodine 3
retinoic acid 3
Hematoxylin 2
N-acetyl-D-glucosamine 2
Coronal 2
PEA 2
A 1 2
BCG 2
MTX 2
glutamic acid 2
EDC 2
Methotrexate 2
STP 2
valine 2
carbonate 2
L-DOPA 2
serine 2
hydroxide 2
cysteine 2
PGE2 2
cAMP 2
TBI 2
barium 2
phosphorus 2
GalNAc 2
copper 2
Thyroxine 2
hexose 2
HCl 2
acrylamide 2
vitamin D 2
hydrazine 1
Nicotine 1
Vinca 1
CBDCA 1
ATP 1
TEM 1
1,3-dithiolane 1
MPA 1
Dioxolane 1
butyric acid 1
DSM 1
SCN 1
PAM 1
Biotin 1
Sildenafil 1
VM-26 1
octyl 1
PGD2 1
H2S 1
BCR 1
1,3-dithiolane-2-thione 1
Indomethacin 1
neopterin 1
formic acid 1
GPT 1
aspartic acid 1
CAM 1
octyl 1
formic acid 1
ACS 1
PEG 1
Triamcinolone acetonide 1
PAP 1
CPT 1
CONV 1
Androgen 1
alcohol dehydrogenase 1
Eosin 1
Nodular 1
aspartic acid 1
DBB 1
Mg2+ 1
VLA 1
Asp 1
AMP 1
Eosin 1
threonine 1
nicotinic acid 1
Cyclosporine 1
nicotinic acid 1
CPT 1
PEG 1
PID 1
salt 1
formic acid 1
FK506 1
Vitamin D 1
PAM 1
LSD 1
2-propanol 1
CAT 1
PAP 1
Dial 1
aspartic acid 1
6-Mercaptopurine 1
formic acid 1
formic acid 1
Etanercept 1
methionine 1
Collagen 1
PAP 1
hyaluronic acid 1
tyrosine 1
Lewis X 1
T10 1
silver 1
Pamidronate 1
selenium 1
Arachidonic acid 1
ABL 1
CAT 1
aspartic acid 1
titanium 1
KOH 1
propionic acid 1
BNP 1
Isoproterenol 1
propionic acid 1
ACS 1
isopropanol 1
octyl 1
aldosterone 1
Amifostine 1
Interleukin-2 1
CBS 1
THP 1
Histone 1
formic acid 1
Guo 1
Methylprednisolone 1
THP 1
Adriamycin 1
formic acid 1
sulfuric acid 1
PAP 1
formic acid 1
Toluidine blue 1
Neurotol 1
MAP 1
Cytochalasin B 1
GlcNAc 1
H2S 1
PGE 1
AME 1
PID 1
2-propanol 1
DHF 1
CBDCA 1
H2O2 1
Carbon 1
BCNU 1
Secretin 1
nicotinic acid 1
NHD 1
butyric acid 1
cobalt 1
formic acid 1
Testosterone 1
1-naphthol 1
ANCA 1
TPA 1
Testosterone 1
CAT 1
nicotinic acid 1
A 71 1
formic acid 1
Guo 1
butyric acid 1