Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019621 (Langerhans cell histiocytosis)
 3,250 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
IGG4 13.3
FAM73A 13.3
CD1a molecule 11.4
ARAF 10.7
PLEKHA6 10.7
CD1a 10.5
Langerin 10.4
non-specific cross reacting antigen 10.3
ZBTB46 10.0
IGK@ 9.9
CD1A 9.9
MAP2K1 9.7
EV2 9.7
CAPZA2 9.5
HLA-DQB2 9.4
MYM 9.3
HLA class I A 9.0
NOTCH1 protein 8.8
CCNB3 8.7
80kD 8.7
LH-2 8.4
PACSIN2 8.4
Tumor protein p53 8.2
Mulibrey nanism 8.2
MAP2K2 8.1
monocarboxylate transporter 2 8.1
MLT1 8.1
TRIM37 8.0
Mast cell tryptase 8.0
BDCA1 7.9
EV1 7.9
factor XIIIa 7.8
CD68 7.7
S100 7.6
DRC1 7.6
interferon alpha A 7.6
IGH@ 7.6
ZNF198 7.5
CD100 7.5
BRAF 7.5
PAK4 7.5
thymocyte antigen 7.4
PAK2 7.3
panhypopituitarism 7.2
FSCN1 7.1
CDw32 7.1
spn 7.1
LYZ 7.0
Programmed cell death 1 7.0
CD11d 7.0
CD1b 7.0
KIAA1549 7.0
HYL 6.9
p21-activated kinase 4 6.9
GSN 6.8
U2AF1 6.8
RAF 6.7
TIM-4 6.7
phosphatidylserine receptor 6.7
CD1c 6.7
NCOA2 6.7
CD1 6.7
PIK3 6.6
RIC 6.6
VMAT1 6.5
CCL23 6.5
stabilin-1 6.5
LAMP3 6.5
PAX-5 6.4
rabphilin 6.4
gonadotropin deficiency 6.4
eosinophil major basic protein 6.4
Jagged2 6.4
HECA 6.3
SIX3 6.3
fascin 6.3
IL2R 6.2
HLA-DRB1*03 6.2
BCOR 6.2
Hallervorden-Spatz syndrome 6.1
interferon-gamma receptor 6.1
cathepsin E 6.1
PE1 6.1
TREM-2 6.1
JAM 6.1
mast cell tryptase 6.0
p130cas 6.0
DUX4 6.0
CD163 6.0
NAB2 6.0
Munc13-4 6.0
KIR2DL4 5.9
NRAS 5.9
LN1 5.9
IL-34 5.9
Ki-1 5.9
Wilms tumor 1 5.9
CD35 5.8
B-RAF 5.8
CD30 antigen 5.8
B-5 5.8
TRK 5.8
SH2D1A 5.8
macrophage derived 5.8
BB1 5.8
PRF1 5.8
folliculin 5.8
CTCL 5.7
PH1 5.7
alpha-1-antichymotrypsin 5.7
PYK2 5.7
GIF 5.6
MKP-3 5.6
antichymotrypsin 5.5
RARA 5.5
MLL2 5.5
p24) 5.4
IP1 5.4
MEKK1 5.4
CDA 5.4
LIMK1 5.3
DMC1 5.3
p125 5.3
MAC-1 5.3
thymopoietin 5.3
leukocyte common antigen 5.3
U1-70K 5.3
p41 5.2
ICOS ligand 5.2
LPA 5.2
MB2 5.2
CSF1 5.2
HPR 5.2
F18 5.2
KMT2D 5.2
NTRK3 5.1
GNAQ 5.1
CHT 5.1
STP 5.1
MMP12 5.1
CD204 5.0
NRSF 5.0
AR protein 5.0
macrophage-derived chemokine 5.0
AWS 5.0
eotaxin-2 5.0
oncogene) 5.0
trichothiodystrophy 5.0
DIA 5.0
CIC 5.0
hyaluronan receptor 5.0
HNF1A 5.0
EED 5.0
NOTCH1 5.0
PIK3R1 4.9
bone) 4.9
Limulus polyphemus 4.9
rhabdomyosarcoma 4.9
SUZ12 4.9
CD58 4.9
more...
Disease
Langerhans cell histiocytosis 13.3
Acquired hemoglobinopathy 13.3
Letterer-Siwe disease 12.9
Hand-Schuller-Christian disease 12.9
Congenital self-healing histiocytosis 12.7
Non-Langerhans cell histiocytosis 12.7
Pulmonary Langerhans cell histiocytosis 12.3
reticulum cell lymphoma 12.3
Erdheim-Chester disease 12.0
Benign cephalic histiocytosis 11.9
Eosinophilic granuloma of bone 11.8
Langerhans cell sarcoma 11.7
Juvenile xanthogranuloma 11.7
reticulohistiocytoma 11.7
Dendritic cell sarcoma 11.7
Pulmonary eosinophilic granuloma 11.7
Generalized eruptive histiocytoma 11.7
Xanthoma disseminatum 11.5
Reticulohistiocytosis 11.3
RB-ILD 11.3
Histiocytic neoplasms 11.3
sinus polyp 11.3
dermoid inclusion 10.9
Ewing's sarcoma metastatic 10.9
Respiratory bronchiolitis-associated interstitial lung disease 10.8
xanthogranuloma 10.7
Sinus Histiocytosis 10.7
Dermatopathic lymphadenopathy 10.4
hepatalgia 10.3
Frosted branch angiitis 10.3
CNS germinoma 10.0
JPD 9.9
Rosai-Dorfman disease 9.9
CNS degenerative disease 9.8
Lymphohistiocytosis 9.8
malignant giant cell tumor of bone 9.7
Canine cutaneous histiocytoma 9.7
Leiner's disease 9.6
Keratosis obturans 9.6
diabetes insipidus 9.5
Jessner's lymphocytic infiltration 9.5
Central diabetes insipidus 9.5
Centrilobular emphysema 9.5
Nodular goiter 9.4
Necrobiotic xanthogranuloma 9.3
adult lymphoblastic lymphoma 9.3
Sclerosing cholangitis 9.2
pyorrhea 9.0
xanthoma 9.0
Interdigitating dendritic cell sarcoma 8.8
multiple nevi 8.8
Granuloma faciale 8.7
honeycomb lung 8.7
Localized disease 8.7
erythema toxicum 8.6
lymphogranuloma 8.6
Nezelof 8.6
Pediatric Tumor 8.6
malignant fibrous histiocytoma of bone 8.5
Multicentric reticulohistiocytosis 8.5
lymphangioleiomyomatosis 8.3
TAR syndrome 8.3
Reactive hemophagocytic syndrome 8.3
FAB L1 8.3
brain stem tumor 8.1
familial hyperlipoproteinemia 8.1
Isolated growth hormone deficiency 8.1
lung cyst 8.1
xanthomatosis 8.1
Thyroid gland 8.1
petrositis 8.0
histiocytoma 7.9
Hemophagocytosis 7.9
Extrahepatic cholestasis 7.8
talcosis 7.8
Histiocytic sarcoma 7.8
dermatofibroma 7.7
anthracosilicosis 7.7
Brodie 7.7
Cutaneous mastocytosis 7.6
panhypopituitarism 7.6
Spontaneous pneumothorax 7.6
orphan disease 7.6
osteosclerosis 7.6
BHD 7.5
recurrent renal cell carcinoma 7.5
Fibroma 7.5
mastoiditis 7.5
Twiddler's syndrome 7.4
Diaper dermatitis 7.4
myofibromatosis 7.4
Granuloma 7.3
Pineal gland 7.3
Pineal gland 7.3
Pineal gland 7.3
hemophagocytic lymphohistiocytosis 7.3
adrenal neoplasm 7.3
generalized disease 7.3
onycholysis 7.3
osteomyelosclerosis 7.3
Anaplastic Lymphoma 7.2
Eosinophilic pustular folliculitis 7.2
hypersensitivity pneumonitis 7.2
chondroblastoma 7.2
cholestatic cirrhosis 7.2
hypothalamic disorder 7.2
germinoma 7.2
interstitial lung disease 7.2
acute suppurative otitis media 7.2
periodontosis 7.2
Bone marrow edema 7.1
otitis externa 7.1
Weber-Christian disease 7.1
urticaria pigmentosa 7.1
pediatric disorder 7.1
Weingarten 7.1
Pulmonary lymphangioleiomyomatosis 7.0
Leukemia cutis 7.0
juvenile myelomonocytic leukemia 7.0
Kimura's disease 7.0
seborrheic dermatitis 7.0
NHD 7.0
rhinoscleroma 6.9
ACTH deficiency 6.9
blepharochalasis 6.9
Spitz nevus 6.9
idiopathic disorder 6.9
paraproteinemia 6.9
Pituitary gland 6.9
Pituitary gland 6.9
Pituitary gland 6.9
rare disease 6.9
CGF 6.9
pituitary dwarfism 6.9
compound nevus 6.8
Lymphocytic hypophysitis 6.8
Follicular dendritic cell sarcoma 6.8
high-risk cancer 6.8
acrodermatitis enteropathica 6.8
Central giant cell granuloma 6.8
craniopharyngioma 6.8
endotheliosis 6.8
brain stem glioma 6.8
Miliary tuberculosis 6.8
Pulmonary veno-occlusive disease 6.7
metastatic neuroblastoma 6.7
Brown tumor 6.7
interstitial pneumonia 6.7
Hajdu-Cheney syndrome 6.7
polyclonal hypergammaglobulinemia 6.7
bronchiolitis 6.6
Hopkins syndrome 6.6
pulmonary granuloma 6.6
dacryoadenitis 6.6
chronic appendicitis 6.6
Multiple tumors 6.6
intradermal nevus 6.5
Candida sepsis 6.5
sarcoidosis 6.5
acute monocytic leukemia 6.5
more...
Symptom
Darier's sign 9.2
General symptoms 8.4
penile lesion 8.1
Radicular pain 7.8
generalized rash 7.7
polydipsia 7.5
thoracic back pain 7.5
otorrhagia 7.2
polyuria 6.9
arm weakness 6.7
non-productive cough 6.7
growing pains 6.6
periorbital edema 6.3
bone pain 6.2
hepatosplenomegaly 6.2
otalgia 5.9
jaw pain 5.7
adipsia 5.7
postnasal drip 5.2
torticollis 5.2
pleuritic chest pain 5.1
halitosis 5.0
hepatomegaly 4.8
paraparesis 4.8
night sweats 4.6
dental pain 4.6
exertional dyspnea 4.5
hip pain 4.4
orthopnea 4.4
Halo 4.4
knee pain 4.4
orofacial pain 4.4
cough 4.3
ankle pain 4.2
clumsiness 4.2
dyspnea 4.2
ataxic gait 4.2
productive cough 4.1
nasal congestion 4.1
splenomegaly 4.1
Gastrointestinal symptoms 4.1
neck stiffness 4.0
dysarthria 4.0
asthenia 3.9
thigh pain 3.9
limb pain 3.9
leg edema 3.9
chronic cough 3.9
fever of unknown origin 3.8
clonus 3.7
ENT 3.7
sciatica 3.7
neck pain 3.6
intestinal bleeding 3.6
pallor 3.5
tachypnea 3.5
cerebellar ataxia 3.4
ataxia 3.4
tinnitus 3.4
leg pain 3.3
vertigo 3.3
chills 3.2
back pain 3.2
hypoproteinemia 3.1
stridor 3.1
erythema 3.0
tonic-clonic seizure 2.9
headache 2.8
shoulder pain 2.8
chest pain 2.8
paresis 2.7
hoarseness 2.7
respiratory distress 2.7
skin damage 2.7
photophobia 2.6
paresthesia 2.6
ophthalmoplegia 2.6
abdominal discomfort 2.5
numbness 2.5
neuralgia 2.5
memory loss 2.4
Ill 2.4
hemoptysis 2.3
blurred vision 2.2
facial pain 2.1
dizziness 2.0
dysuria 2.0
shortness of breath 1.9
dry eye 1.9
anorexia 1.8
cachexia 1.8
lethargy 1.8
pain 1.8
snoring 1.8
weakness 1.7
abdominal pain 1.7
vomiting 1.6
epigastric pain 1.5
collapse 1.5
cyanosis 1.4
pelvic pain 1.3
apathy 1.3
diarrhea 1.3
dystonia 1.2
seizures 1.2
nausea 1.1
wheezing 1.0
low back pain 1.0
constipation 0.9
fatigue 0.8
tremor 0.7
arthralgia 0.4
spasm 0.4
anesthesia 0.1
syncope 0.1
Welt -0.7
hypothermia -0.8
discomfort -1.2
discomfort -1.3
overweight -1.4
analgesia -1.5
Drug
Velban 9.0
Methotrexat 8.2
Spiriva 8.2
Teniposide 6.7
Etoposide 6.6
DDAVP 6.2
DDAVP 6.1
SMP 5.7
-deoxyadenosine 5.4
ARA-C 5.4
Magnevist 5.3
Zoledronic acid 5.3
Prednisone 5.3
Amifostine 4.7
TRM 4.7
Zoledronic acid 4.6
Prednisolone 4.3
Paraffin 4.2
Denosumab 4.2
Lenalidomide 3.9
Secretin 3.7
Campath 3.7
Campath 3.7
CIA 3.6
Methylprednisolone 3.4
Dermatol 3.3
AraC 3.2
NAG 3.2
Infliximab 3.1
Infliximab 3.1
CCL 2.9
Fluconazole 2.9
ENT 2.8
Itraconazole 2.3
Frontal 2.2
ACT 2.2
MDS 2.1
Imatinib 2.0
CSF 1.9
HCG 1.9
ADM 1.6
HCH 1.5
Fluorescein 1.4
Adriamycin 1.1
G-CSF 0.9
Leaf 0.9
CAM 0.7
Mutagen 0.7
Indomethacin 0.6
IL-2 0.0
IFN-gamma -0.6
MAP -0.7
lactose -0.8
Asthma -1.4
Dial -1.6
Cardiovasc -1.8
Monit -1.8
Enzyme
SMP 5.8
alpha-mannosidase 4.7
catechol 1,2-dioxygenase 4.7
MDP 4.4
STK11 4.4
BAL 4.3
MEK 4.3
lysozyme 4.1
tryptase 3.8
PGM 3.8
transglutaminase 3.6
BMT 3.5
cathepsin K 3.4
mitogen-activated protein kinase 2.9
acid phosphatase 2.6
alpha-galactosidase 2.5
prostaglandin synthetase 2.4
MEKK1 2.4
TdT 2.4
botulinum neurotoxin 2.4
ERK 2.3
phosphoglycerate kinase 2.2
ADH 2.1
acetyl-CoA carboxylase 1.8
CPT 1.6
granzyme B 1.6
CPT 1.5
CD13 1.4
cathepsin D 1.2
cathepsin B 1.2
MMP 1.2
gamma-glutamyl transpeptidase 1.1
CPT 1.1
topoisomerase 1.1
MIP 1.0
topoisomerase 1.0
peroxidase 1.0
adenosine deaminase 0.9
adenosine deaminase 0.9
alkaline phosphatase 0.9
chymotrypsin 0.8
phosphoinositide 3-kinase 0.7
AST 0.7
phosphodiesterase 0.6
focal adhesion kinase 0.6
alanine aminotransferase 0.6
cellulase 0.5
MAP 0.4
beta-glucuronidase 0.4
cdc2 0.2
alcohol dehydrogenase 0.1
lactate dehydrogenase 0.0
CD10 0.0
trypsin -0.1
reverse transcriptase -0.1
urokinase-type plasminogen activator -0.1
aspartate aminotransferase -0.1
phosphatidylinositol 3-kinase -0.2
protein kinase -0.5
PARP -0.5
neuraminidase -0.6
ATPase -0.7
protein kinase C -0.7
ACE -0.9
collagenase -0.9
phospholipase C -0.9
lipase -0.9
creatine kinase -0.9
glutathione peroxidase -1.2
proteasome -1.6
RNA polymerase -1.8
luciferase -2.0
catalase -2.5
ACS -3.0
Compound
1,3-dithiolane-2-thione 11.7
Dioxolane 7.7
1,3-dithiolane 7.5
NHD 7.1
CONV 7.1
Vinblastine 7.0
VP-16 6.0
DBB 6.0
Triamcinolone acetonide 5.4
CDA 5.4
Pamidronate 5.2
Prednisone 5.2
Belt 5.1
STP 5.0
Amifostine 4.7
MEK 4.6
6-Mercaptopurine 4.6
VLA 4.5
DHF 4.4
A 42 4.3
Prednisolone 4.3
AME 4.2
Ara-C 4.2
Coronal 4.1
Toluidine blue 4.0
PNA 4.0
Etanercept 4.0
Neo 3.9
PEA 3.9
Vinca 3.9
BAL 3.8
A 3 3.8
Ara-C 3.8
Thyroxine 3.7
Secretin 3.7
Cytochalasin B 3.6
Methylprednisolone 3.5
VM-26 3.5
EDC 3.4
Nodular 3.4
1-naphthol 3.3
Eosin 3.3
PID 3.2
Sildenafil 3.2
PID 3.2
MTX 3.2
Lewis X 3.0
N-acetyl-D-glucosamine 3.0
Eosin 3.0
Hematoxylin 2.9
TBI 2.9
Thyroid 2.8
DTPA 2.8
Letter 2.8
CBDCA 2.8
CBDCA 2.8
MPA 2.8
Interleukin-2 2.8
PAS 2.6
Biotin 2.5
LSD 2.5
6-12 2.5
BNP 2.4
ANCA 2.4
methane 2.4
PGD2 2.4
neopterin 2.2
TRH 2.2
fluorine 2.2
A 71 2.1
BCNU 2.1
DBA 2.1
DBA 2.1
T10 2.0
GPT 2.0
Optimal 2.0
Methotrexate 2.0
Arachidonic acid 2.0
PAP 1.9
DBA 1.8
leucine 1.8
2-propanol 1.7
2-propanol 1.7
nicotinic acid 1.7
nicotinic acid 1.7
Androgen 1.7
TSH 1.7
Guo 1.6
nicotinic acid 1.6
CPT 1.6
A 1 1.6
PAP 1.6
PAP 1.6
GalNAc 1.6
PAP 1.5
His 1.5
CPT 1.5
SCN 1.5
CBS 1.4
PAM 1.3
PAM 1.3
formaldehyde 1.3
nicotinic acid 1.2
hexose 1.2
BCG 1.1
L-DOPA 1.1
prostacyclin 1.1
Guo 1.0
Histone 1.0
ACTH 1.0
Cyclosporine 0.9
formaldehyde 0.9
Clin 0.9
KOH 0.9
TPA 0.8
hydrazine 0.8
Indomethacin 0.8
octyl 0.8
octyl 0.8
octyl 0.8
FK506 0.8
butyric acid 0.8
ABL 0.7
Testosterone 0.7
Testosterone 0.7
galactose 0.7
butyric acid 0.6
propionic acid 0.6
propionic acid 0.6
BCR 0.6
Vitamin D 0.6
Isoproterenol 0.5
butyric acid 0.5
PGE2 0.4
valine 0.4
Neurotol 0.4
H2S 0.4
TNF 0.4
H2S 0.3
retinoic acid 0.3
barium 0.3
glutamic acid 0.2
Adriamycin 0.2
alcohol dehydrogenase 0.2
acrylamide 0.2
sulfuric acid 0.2
PGE 0.2
CAT 0.1
CAT 0.1
Collagen 0.1
Nicotine 0.1
MAP 0.0
isopropanol 0.0
CAT 0.0
Carbon -0.0
formic acid -0.1
formic acid -0.1
formic acid -0.1
formic acid -0.1
formic acid -0.1
more...