Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019621 (Langerhans cell histiocytosis)
 3,250 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
CD1a 338
Sep 216
BRAF 175
CD68 121
S100 120
MRI 97
Langerin 88
She 88
lymphoid 57
MAP2K1 41
thymus 38
cytokine 38
lysozyme 36
MAPK 35
CD1 35
MEK 33
FDG 31
HLA-DR 31
ERK 31
CD4 29
rhabdomyosarcoma 24
interferon 23
Pol 23
CD34 22
RAF 21
collagen 21
vasopressin 21
HLA 20
nodal 20
osteosarcoma 19
Mol 17
CD14 17
reserved 17
growth hormone 16
panhypopituitarism 16
non-Hodgkin's lymphoma 16
lectin 15
factor XIIIa 15
CD163 14
NRAS 13
extracellular signal-regulated kinase 13
CD8 13
Ki-67 12
IL-17 11
IL-1 11
Mal 11
p53 11
vimentin 11
CD11c 11
PHA 10
ARAF 10
KRAS 10
peroxidase 9
alkaline phosphatase 9
E-cadherin 9
esterase 9
insulin 9
MAC 9
TNF 8
CD2 8
hairy 8
CD11b 8
acid phosphatase 8
IFN 8
neurofibromatosis 8
macrophage colony-stimulating factor 8
ALL 8
tumor necrosis factor 7
interferon alpha 7
CD20 7
CD31 7
CD56 7
lacrimal 7
fascin 7
androgen receptor 7
PI3K 7
X-linked 7
CD25 7
proto-oncogene 7
CD30 7
PIK3CA 7
CSF 7
GM-CSF 7
IL-1 beta 6
mucin 6
X-linked recessive 6
antichymotrypsin 6
cyclin D1 6
p21 6
interferon-gamma 6
alpha-fetoprotein 6
hemoglobin 6
LDH 6
CD1A 6
ENT 6
granulocyte-macrophage colony-stimulating factor 6
IL-6 6
MDP 6
AML 6
IL-4 6
keratin 6
p16 6
bone) 6
CD1c 5
proliferating cell nuclear antigen 5
severe combined immunodeficiency 5
C-reactive protein 5
ICAM-1 5
Hop 5
CD45 5
alpha 1-antitrypsin 5
CD15 5
human leukocyte antigen 5
phosphatase 5
p38 5
arginine vasopressin 5
mast cell 5
endoplasmic reticulum 4
NF1 4
CDKN2A 4
LFA-1 4
scratch 4
osteopontin 4
BAL 4
CD83 4
CD5 4
CDA 4
chemokine 4
TGF-beta 4
ALK 4
IL1 4
LHRH 4
glycoprotein 4
MEK1 4
IgA 4
chemokine receptor 4
CD35 4
JAK2 4
Bcl-2 4
AR protein 4
AKT 4
FOXP3 4
tyrosine kinase 4
IL-8 4
IL-10 4
DBA 4
glial fibrillary acidic protein 4
HLA class I 4
ferritin 4
Cytokine 4
NMR 4
CD86 4
interferon-alpha 4
MAP kinase 4
SCT 4
CD1b 4
NOTCH1 4
ACTH 4
dilute 4
COD 3
more...
Disease
Langerhans cell histiocytosis 3250
tumor 371
cancer 313
diabetes insipidus 261
Erdheim-Chester disease 206
Letterer-Siwe disease 205
rare disease 153
sarcoidosis 126
xanthogranuloma 113
lymphoma 112
lymphadenopathy 104
Hodgkin's disease 80
Rosai-Dorfman disease 74
leukemia 74
interstitial lung disease 70
lung disease 68
pneumothorax 66
interstitial pneumonia 64
sarcoma 62
carcinoma 60
Juvenile xanthogranuloma 58
systemic disease 57
bronchiolitis 53
metastases 51
rash 50
idiopathic pulmonary fibrosis 50
lymphangioleiomyomatosis 50
emphysema 49
xanthoma 48
tuberculosis 48
pneumonia 47
neuroblastoma 40
Hand-Schuller-Christian disease 36
pulmonary fibrosis 33
respiratory failure 33
melanoma 32
acute lymphoblastic leukemia 32
Ewing's sarcoma 31
dysplasia 31
cholangitis 30
anemia 29
hypersensitivity pneumonitis 28
immunodeficiency 28
proptosis 27
hemophagocytic lymphohistiocytosis 27
acute myeloid leukemia 27
multiple myeloma 25
osteomyelitis 25
hypothyroidism 25
rhabdomyosarcoma 24
Hashimoto's thyroiditis 24
hemangioma 23
chronic obstructive pulmonary disease 23
osteosarcoma 23
pulmonary hypertension 23
histiocytoma 22
goiter 22
Pulmonary Langerhans cell histiocytosis 21
Langerhans cell sarcoma 21
thrombocytopenia 20
non-Hodgkin's lymphoma 20
liver disease 20
craniopharyngioma 19
bronchiectasis 18
amyloidosis 18
rheumatoid arthritis 17
lung cancer 17
eosinophilia 17
seborrheic dermatitis 17
reticulohistiocytoma 17
Epstein 17
panhypopituitarism 17
osteosclerosis 17
chondrosarcoma 16
bone disease 16
otitis externa 15
diabetes 15
adenocarcinoma 15
virus infection 15
dermatitis 14
germinoma 14
mole 14
meningioma 14
cirrhosis 14
hypopituitarism 14
acute leukemia 14
graft-versus-host disease 14
otitis media 13
mastoiditis 13
Wegener's granulomatosis 13
immune deficiency 13
cytomegalovirus 13
hypogonadism 13
osteoma 13
pruritus 12
mastocytosis 12
vasculitis 12
hematologic malignancies 12
fibrosarcoma 12
hypertension 12
infectious diseases 12
myelodysplastic syndrome 11
Central diabetes insipidus 11
neutropenia 11
psoriasis 11
WT1 11
pancytopenia 11
lupus 11
pneumoconiosis 11
lymphadenitis 11
hyperprolactinemia 11
pathological fracture 11
Thorax 10
myeloproliferative disorders 10
childhood cancer 10
MAC 10
lymphoproliferative disorders 10
growth hormone deficiency 10
squamous cell carcinoma 10
vascular disease 10
meninges 10
systemic lupus erythematosus 10
sensorineural hearing loss 10
fibroma 10
PHA 10
asthma 10
confusion 10
periodontitis 9
mycosis fungoides 9
plaque 9
aggression 9
hepatitis 9
neoplastic process 9
cystic fibrosis 9
adenoma 9
osteochondroma 9
dermatofibroma 9
obesity 9
skin disease 9
HIV 8
amenorrhea 8
eczema 8
hypogonadotropic hypogonadism 8
neurofibromatosis 8
primitive neuroectodermal tumor 8
germ cell tumor 8
chondroblastoma 8
retinoblastoma 8
paraproteinemia 8
Pituitary 8
malignant fibrous histiocytoma 8
xanthomatosis 8
plasmacytoma 8
acute monocytic leukemia 8
pericardial effusion 8
brain tumor 8
primitive neuroectodermal tumor 8
periodontal disease 7
protein-losing enteropathy 7
thyroiditis 7
more...
Symptom
pain 91
dyspnea 51
cough 49
headache 41
polydipsia 41
polyuria 38
hepatosplenomegaly 33
bone pain 24
seizures 19
hepatomegaly 17
splenomegaly 17
ataxia 17
diarrhea 14
weakness 13
respiratory distress 13
chest pain 12
anesthesia 12
back pain 11
erythema 11
abdominal pain 10
vomiting 10
fatigue 9
paraparesis 8
collapse 8
exertional dyspnea 8
vertigo 7
tinnitus 7
ENT 7
otalgia 6
torticollis 6
dysarthria 6
Ill 6
knee pain 6
anorexia 5
neck pain 5
nausea 5
asthenia 4
hip pain 4
chills 4
paresis 4
dizziness 4
cerebellar ataxia 4
pallor 3
chronic cough 3
Darier's sign 3
paresthesia 3
dental pain 3
fever of unknown origin 3
tachypnea 3
tremor 3
generalized rash 3
hemoptysis 3
night sweats 3
non-productive cough 3
numbness 3
pleuritic chest pain 2
shortness of breath 2
constipation 2
stridor 2
ophthalmoplegia 2
penile lesion 2
dystonia 2
productive cough 2
memory loss 2
periorbital edema 2
halitosis 2
arm weakness 2
orofacial pain 2
hoarseness 2
sciatica 2
cachexia 2
leg pain 2
lethargy 2
low back pain 2
General symptoms 2
nasal congestion 2
shoulder pain 2
snoring 1
Welt 1
apathy 1
spasm 1
photophobia 1
growing pains 1
Gastrointestinal symptoms 1
clonus 1
cyanosis 1
thoracic back pain 1
syncope 1
intestinal bleeding 1
pelvic pain 1
dysuria 1
blurred vision 1
ankle pain 1
tonic-clonic seizure 1
arthralgia 1
facial pain 1
adipsia 1
neuralgia 1
Halo 1
analgesia 1
clumsiness 1
discomfort 1
postnasal drip 1
dry eye 1
otorrhagia 1
neck stiffness 1
overweight 1
leg edema 1
discomfort 1
Radicular pain 1
skin damage 1
hypoproteinemia 1
wheezing 1
hypothermia 1
jaw pain 1
abdominal discomfort 1
thigh pain 1
epigastric pain 1
ataxic gait 1
limb pain 1
orthopnea 1
Drug
Dermatol 267
CSF 12
Etoposide 11
-deoxyadenosine 9
DDAVP 7
DDAVP 7
Cardiovasc 6
ENT 6
Paraffin 4
Velban 4
Leaf 4
Prednisone 4
IL-2 3
Prednisolone 3
NAG 2
SMP 2
Zoledronic acid 2
IFN-gamma 2
Zoledronic acid 2
Infliximab 1
Spiriva 1
Denosumab 1
Campath 1
AraC 1
Campath 1
MDS 1
Magnevist 1
Lenalidomide 1
ADM 1
ACT 1
Dial 1
Fluconazole 1
MAP 1
Teniposide 1
CIA 1
HCG 1
Adriamycin 1
CCL 1
Methotrexat 1
Methylprednisolone 1
Monit 1
Mutagen 1
Infliximab 1
TRM 1
Itraconazole 1
Imatinib 1
G-CSF 1
Secretin 1
Fluorescein 1
Frontal 1
Amifostine 1
ARA-C 1
HCH 1
Asthma 1
CAM 1
Indomethacin 1
lactose 1
Enzyme
mitogen-activated protein kinase 72
ERK 47
lysozyme 37
MEK 36
peroxidase 13
alkaline phosphatase 9
acid phosphatase 8
focal adhesion kinase 7
transglutaminase 6
protein kinase 6
MDP 6
ATPase 4
alpha-mannosidase 4
trypsin 4
tryptase 4
SMP 4
alanine aminotransferase 4
BAL 4
phosphodiesterase 3
protein kinase C 3
BMT 3
reverse transcriptase 3
lactate dehydrogenase 3
topoisomerase 2
cathepsin K 2
PGM 2
aspartate aminotransferase 2
chymotrypsin 2
topoisomerase 2
gamma-glutamyl transpeptidase 2
AST 1
phosphatidylinositol 3-kinase 1
STK11 1
CD13 1
CD10 1
RNA polymerase 1
MIP 1
adenosine deaminase 1
ACE 1
proteasome 1
phosphoglycerate kinase 1
catalase 1
catechol 1,2-dioxygenase 1
ADH 1
neuraminidase 1
cathepsin D 1
MMP 1
CPT 1
ACS 1
phosphoinositide 3-kinase 1
alpha-galactosidase 1
urokinase-type plasminogen activator 1
TdT 1
glutathione peroxidase 1
PARP 1
phospholipase C 1
collagenase 1
prostaglandin synthetase 1
acetyl-CoA carboxylase 1
cdc2 1
alcohol dehydrogenase 1
CPT 1
MAP 1
CPT 1
beta-glucuronidase 1
adenosine deaminase 1
luciferase 1
creatine kinase 1
cathepsin B 1
MEKK1 1
botulinum neurotoxin 1
lipase 1
granzyme B 1
cellulase 1
Compound
Clin 290
Dec 206
DNA 54
MEK 32
His 23
water 21
VP-16 21
leucine 21
nitrogen 15
oxygen 15
methane 14
glucose 13
galactose 12
sodium 11
Thyroid 11
A 3 11
acetate 9
iron 9
fluorine 8
CO2 8
Vinblastine 8
TNF 8
Optimal 7
A 42 6
Prednisone 6
Letter 5
TSH 5
potassium 5
formaldehyde 5
ethanol 5
DTPA 5
Neo 5
PAS 4
Cardiol 4
DBA 4
DBA 4
6-12 4
ACTH 4
zinc 4
nitric oxide 4
calcium 4
hydrogen 4
CDA 4
DBA 4
urea 4
PNA 4
Belt 4
BAL 4
iodine 3
formaldehyde 3
acetic acid 3
Prednisolone 3
prostacyclin 3
TRH 3
creatinine 3
Ara-C 3
arginine 3
Ara-C 3
retinoic acid 3
sulfate 3
N-acetyl-D-glucosamine 2
PEA 2
EDC 2
A 1 2
Hematoxylin 2
serine 2
glutamic acid 2
Thyroxine 2
hydroxide 2
STP 2
carbonate 2
cAMP 2
HCl 2
barium 2
MTX 2
GalNAc 2
Coronal 2
PGE2 2
TBI 2
cysteine 2
L-DOPA 2
phosphorus 2
copper 2
BCG 2
valine 2
hexose 2
Methotrexate 2
acrylamide 2
vitamin D 2
hydrazine 1
Nicotine 1
Vinca 1
CBDCA 1
ATP 1
TEM 1
1,3-dithiolane 1
MPA 1
Dioxolane 1
butyric acid 1
DSM 1
SCN 1
PAM 1
Biotin 1
Sildenafil 1
VM-26 1
octyl 1
PGD2 1
H2S 1
BCR 1
1,3-dithiolane-2-thione 1
Indomethacin 1
neopterin 1
formic acid 1
GPT 1
aspartic acid 1
CAM 1
octyl 1
formic acid 1
Etanercept 1
formic acid 1
CPT 1
methionine 1
tyrosine 1
Nodular 1
VLA 1
alcohol dehydrogenase 1
Arachidonic acid 1
Asp 1
AMP 1
Eosin 1
DBB 1
Mg2+ 1
BNP 1
propionic acid 1
CPT 1
PEG 1
nicotinic acid 1
Amifostine 1
ACS 1
LSD 1
CAT 1
aspartic acid 1
6-Mercaptopurine 1
salt 1
formic acid 1
FK506 1
Vitamin D 1
Guo 1
THP 1
PAP 1
T10 1
formic acid 1
silver 1
Pamidronate 1
sulfuric acid 1
titanium 1
PGE 1
AME 1
CBS 1
2-propanol 1
more...