Gene/Protein
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Symptom
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Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UMLS:C0019621 (
Langerhans cell histiocytosis
)
3,250
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Langerhans cell histiocytosis
(
LCH
) is a neoplastic disorder that results in clonal proliferation of cells with a Langerhans cell (LC) phenotype. The pathogenesis of
LCH
is still poorly understood. In the present study, serial analysis of gene expression (SAGE) was applied to LCs generated from umbilical cord blood CD34+ progenitor cells to identify LC-specific genes and the expression of these genes in
LCH
was investigated. Besides the expression of several genes known to be highly expressed in LCs and
LCH
such as CD1a, LYZ, and CD207, high expression of genes not previously reported to be expressed in LCs, such as GSN,
MMP12
, CCL17, and CCL22, was also identified. Further analysis of these genes by quantitative RT-PCR revealed high expression of FSCN1 and GSN in all 12
LCH
cases analysed; of CD207,
MMP12
, CCL22, and CD1a in the majority of these cases; and CCL17 in three of the 12 cases. Immunohistochemistry confirmed protein expression in the majority of cases. The expression of
MMP12
was most abundant in multi-system
LCH
, which is the
LCH
type with the worst prognosis. This suggests that expression of
MMP12
may play a role in the progression of
LCH
. These data reveal new insight into the pathology of
LCH
and provide new starting points for further investigation of this clonal proliferative disorder.
...
PMID:Gene expression analysis of dendritic/Langerhans cells and Langerhans cell histiocytosis. 1671 46
