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Query: UMLS:C0019621 (Langerhans cell histiocytosis)
 3,250 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors report a rare case of diffuse histiocytosis X in an adult aged 47 followed up for 12 years. There was extensive skeletal and oral dissemination but without visceral, cutaneous or neurological involvement. Blood investigations showed only a raised erythrocyte sedimentation rate. The literature of histiocytosis is reviewed; few papers could be found concerning this type of disease in adults.
Rev Chir Orthop Reparatrice Appar Mot
PMID:[Chronic disseminated histiocytosis in the adult. Apropos of a case with a 12-year remission]. 14 12

Histiocytosis X is still of unknown origin. Its clinical patterns are various and it is above all a bone disease of children, mostly boys. It is a tumoral condition basically benign but with a strong tendency toward dissemination and destruction. Its natural history is unpredictable. The authors have reviewed 37 cases after a 44 months mean follow-up for bringing up a better understanding of the role of orthopedic surgery. The diagnosis was always based on biopsies looking for at least two basic signs out of four possible ones. Scintigraphy was used to detect other locations. MRI was used to evaluate the effect of treatment. In single eosinophilic granuloma, curettage was associated with biopsy. Local injections of corticoids may help in spinal locations. In disseminated forms, surgical treatment should be little aggressive, limited to a biopsy of the most superficial lesion. These forms should be treated by radiotherapy corticotherapy and chemotherapy, as well as the aggressive lesions, the extensive ones, the threatening ones and those which are not accessible.
Rev Chir Orthop Reparatrice Appar Mot 1992
PMID:[Localizations of histiocytosis X in bone]. 141 Jul 17

Langerhans' histiocytosis or histiocytosis X is a rare intrinsically benign disease producing a destructive tumor with a variable clinical presentation and an often unpredictable clinical course. Focal forms such as eosinophilic granuloma of the bone only require minimal care but the gravity of multisystem forms causing organic dysfunction sometimes require aggressive chemotherapy. Bone involvement is generally observed in children mostly boys. Both sporadic and chronic forms are noted. We report a case observed in a 17-year-old adolescent who presented an exceptional association of bony destruction of the pelvis with extended asymptomatic pulmonary involvement. The lung disease led to the initial diagnosis and optimal surgical, pathological and radiological management.
Rev Chir Orthop Reparatrice Appar Mot 2007 Sep
PMID:[Ischemic eosinophilic granuloma and pulmonary histiocytosis with a regressive course]. 1787 42