Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019621 (Langerhans cell histiocytosis)
 3,250 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Histiocytosis-X may involve many tissues, including the central nervous system. This report is the first documentation of histiocytosis-X occurring exclusively in the spinal cord. We present a patient with cervical spinal cord disease causing spastic paraplegia, flaccid right arm weakness, and sensory loss. Magnetic resonance imaging of the spinal cord clearly demonstrated the entire lesion. Following surgical decompression and biopsy, the cervical spinal cord was treated with low-dose radiation, which resulted in complete regression of the lesion by radiologic assessment. The child became neurologically normal, and histiocytosis-X has not been detected in other organ systems.
 ...
PMID:Histiocytosis-X isolated to the cervical spinal cord. 349 27

Although Langerhans cell histiocytosis (LCH) may arise from any bone, flat bones (skull, ribs, scapula, clavicle, and mandible) are more commonly involved.The overall reported incidence of scapular involvement by LCH is nearly 3% in the literature. Intra-lesional corticosteroid injection can be given for lesions that cause pain or postural deformity. We, herein, report a 26-year male with scapular LCH who was suffering from right shoulder pain and right arm weakness. The patient received intra-lesional methylprednisolone under CT-guidance for treatment. On follow-up imaging, almost total regression was observed. We suggest that percutaneous CT-guided intra-lesional steroid injection is an efficient method for the treatment of LCH located in bone. Key Words: Bone, Langerhans cell histiocytosis, Local treatment, Corticosteroid.
 ...
PMID:Radiologic Findings of Scapular Langerhans Cell Histiocytosis Successfully Treated with CT-Guided Corticosteroid Injection. 3281 9