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Query: UMLS:C0019621 (Langerhans cell histiocytosis)
 3,250 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Langerhans cell histiocytosis (LCH) is a rare disorder which mainly affects children. Oral changes, such as gingival ulceration, halitosis, osseous lesions associated with tooth mobility, and early loss of primary teeth, comprise the disease's first manifestations for most patients. In the long term, dental changes may occur as a result of dental and systemic treatment. Therefore, this study's purpose is to report Langerhans cell histiocytosis' effects on the permanent dentition 8 years after diagnosis, which had been established by performing a biopsy of gingival tissue on a 3-year-old patient.
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PMID:Langerhans cell histiocytosis: impact on the permanent dentition after an 8-year follow-up. 1850 51

On examination, the oral cavity may exhibit manifestations of underlying systemic disease and serve as an indicator of overall health. Systemic diseases with oral findings include autoimmune, hematologic, endocrine, and neoplastic processes. Autoimmune disease may manifest as oral ulcerations, changes in the salivary and parotid glands, and changes in the tongue. Patients with hematologic illnesses may present with gingival bleeding or tongue changes such as glossitis, depending on the etiology. Oral changes associated with endocrine illness are variable and depend on the underlying condition. Neoplastic changes include metastatic lesions to the bony and soft tissues of the oral cavity. Patients with chronic diseases such as gastroesophageal reflux and eating disorders may present with dental erosions that cause oral pain or halitosis. In the pediatric population, oral changes can be related to rare cancers, such as Langerhans cell histiocytosis, or infectious etiologies, such as Kawasaki disease. In both adults and pediatric patients, poor oral health has been linked to poorer health outcomes overall. Thorough history taking and physical examination by dentists may aid in determining the underlying etiology of oral changes and allow for earlier intervention by medical colleagues.
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PMID:Oral manifestations of systemic disease. 2909 62