Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019621 (Langerhans cell histiocytosis)
 3,250 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immunohistochemical study of 7 cases of histiocytosis X (HX) and of histologically normal skin shows that HX Langerhans cells react with Bl.49.9 monoclonal antibody which recognizes the Interleukin-2 receptor, whereas normal skin Langerhans cells do not. This reactivity suggest activation of HX Langerhans cells.
 ...
PMID:Histiocytosis X Langerhans cells react with antiinterleukin-2 receptor monoclonal antibody. 313 Jun 19

Although several attempts at the immunohistochemical characterization of histiocytosis have recently been made there is only one paper which reports a case of cerebral Langerhans cell histiocytosis (LCH) diagnosed by biopsy. This paper presents a bioptically diagnosed case of juvenile histiocytosis. The panel of antibodies used was as follows: anti-S-100, 2 different antibodies to anti-interleukin 2, anti-lysozyme, anti-LEU M1, anti-MAC 387, anti-major histocompatibility complex II and anti-GFAP. Microglia markers--Griffonia simplicifolia and RCA 1 lectins were also utilized. The proliferating cells produced a positive response to S-100, lysozyme and a partially positive response to HLA DR, but responded negatively to MAC 387, LEU M1, lectins, IL2R and GFAP. Our results were compared and analyzed in the light of those obtained by other authors.
 ...
PMID:Immunohistological study of a case of cerebral Langerhans cell histiocytosis in brain biopsy. 772 76