Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019270 (hernia)
 15,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Additional findings concerning the evolution alpha fetoprotein (AFP) are reported in this letter. AFP levels of 440 amniotic fluids and 469 maternal sera were studied at different gestational ages. In addition, amniotic fluids and serum samples of 180 pregnant women were collected on the same day. Comparative study of amniotic fluid and maternal sera levels of AFP led to establishment of parallelism between these values from Week 17-20 of gestation. During this period, the ratio of amniotic fluid:maternal serum AFP was always between 100 and 250, whereas, it was less than 80 after Week 21 and greater than 400 before the 16th week. Fetal blood contamination of 2 samples resulted in high-for-date AFP levels, and subsequent amniocenteses were normal for AFP. In 2 twin pregnancies, the AFP value was normal in amniotic fluid and increased in maternal serum. The ratio was low for dates--about 1/2 normal. In cases with abnormalities the ratio was abnormal. High AFP levels in serum with normal amniotic values in 2 pregnant patients with renal disease were found: in these cases, the ratio was low for gestational age, but not as low as that observed in cases of intrauterine death. Ratios were too high for gestational age in cases of anencephaly and umbilical hernia.
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PMID:Letter: Alpha fetoprotein in amniotic fluid and maternal serum. 5 80

A 36-year-old male with history of left orchiopexy at age 11 received medical examination at the emergency department of our hospital with a left painful inguinal tumor as the chief complaint. A surgeon examined and suspected a femoral hernia. However, he noticed the patient having a tumor in the left scrotum as well, and referred the patient to our department. Alpha-fetoprotein was within the normal range, but beta-human chorionic gonadotropin and lactate dehydrogenase were slightly elevated. We diagnosed the case as a left testicular tumor and performed left high orchiectomy. On histopathological examination, the tumor was a seminoma and the left inguinal tumor was a lymph node metastasis (3 x 4 x 5 cm). After operation, the tumor markers became normal and radiographic examination showed no evidence of metastasis to the retroperitoneal lymph nodes and to other organs. Subsequently, the patient was given 2 courses of systemic chemotherapy (bleomycin, etoposide, cisplatin) as an adjuvant therapy. At present, eleven months after operation, he showed no evidence of recurrence. To the best of our knowledge, there are 47 reported cases of this disease including ours in Japan.
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PMID:[Testicular tumor following orchiopexy: a case report]. 1697 32