Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019270 (hernia)
 15,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Methionine-enkephalin (ME-IR) and beta-endorphin (BE-IR) immunoreactive material CSF concentrations have been measured in subjects of different ages affected by lumbar or cervical disk hernia. The two peptides exhibited different age-related trends. ME-IR levels rose significantly with age while no changes were observed in the case of BE-IR.
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PMID:Age-related changes of methionine-enkephalin and beta-endorphin/beta-lipotropin immunoreactivity in human CSF. 297 45

A male infant with secondary hypothyroidism is described. Within the first month after birth, the patient manifested feeding difficulties, lethargy, persistent jaundice, umbilical hernia, and large anterior and open posterior fontanels. The roentgenogram of the knee joints at 27 days showed absence of the distal femoral epiphyses. His serum thyroid-stimulating hormone (TSH) level was low despite decreased levels of triiodothyronine (T3) and tetraiodothyronine (T4) in serum. Assessment of the hypothalamic-pituitary hormone (TRH) nor growth hormone (GH) responses to L-arginine and insulin, while responses of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to luteinizing hormone-releasing hormone (LH-RH) and adrenocorticotropic hormone (ACTH) to insulin were within normal limits. The malady of the patient in this case was not detected by newborn screening for congenital hypothyroidism due to the fact that in the Aomori district of Japan thyroid screening involves only the measurement of TSH. Such measurement cannot detect cases of secondary or tertiary hypothyroidism such as our patient. Replacement therapy was initiated at 58 days and his physical and mental development has been regarded as normal since treatment.
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PMID:Congenital secondary hypothyroidism with low serum GH and prolactin levels in a 27-day-old male infant. 628 48

This study was undertaken to investigate the effects of bupivacaine on beta-endorphin (BE) and cortisol (C) release and postoperative pain in children. Thirty children aged 1 month to 2 years undergoing outpatient inguinal hernia under general anesthesia were randomized into three groups. Wound infiltration in group 1 patients (precisional group) was performed with 0.5 ml/ kg 0.25% bupivacaine following anesthesia induction but prior to surgery. Group 2 patients (postincisional group) had wound infiltration with bupivacaine following repair of the hernia but before skin closure. Group 3 patients (control group) did not receive any local anesthetic. In the post-anesthesia care unit (PACU) objective pain assessments were performed every 5 min using a standardized ten-point objective pain scale. Plasma C concentrations increased at the end of the operation in all groups, but this increase was significant only in the control group (P < 0.001). There was no significant difference between the pre- and postincisional groups with regard to pre- and postoperative C alterations (P > 0.05). Although plasma BE concentrations increased significantly at the end of the operation in the control group (P < 0.001), no significant difference was found between pre- and postoperative values in the infiltration groups. There was a more marked difference in BE release between the preincisional and control groups (P < 0.001) than the postincisional group (P < 0.05). Although the objective pain scores were not statistically different upon PACU arrival, the patients in the infiltration groups achieved a pain score of 0 much more quickly than those in the control group (P < 0.05). These findings suggest that wound infiltration with bupivacaine decreases the stress response to surgery and postoperative pain.
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PMID:Effects of bupivacaine infiltration on beta-endorphin and cortisol release and postoperative pain following inguinal herniorrhaphy in children. 2405 69